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Empowering Patients' Lung Cancer Screening Uptake (Empower LCS/Call+)
Recruiting
Empowering Patients' Lung Cancer Screening Uptake (Empower LCS/Call+): A Multi-Site Pilot Randomized Controlled Trial
Who can join
Ages 50 to 80 · All sexes
Full eligibility criteria
Inclusion Criteria:
1. Must meet current USPSTF eligibility criteria for lung cancer screening (Current criteria: age 50-80 years old with a 20 pack-year smoking history, who currently smoke or have quit within the last 15 years)
2. Must have an electronic health record-assigned primary care provider within University of California Irvine Health or Emory Healthcare
3. Must have recent engagement with respective health system (i.e., office or emergency department (ED) visit, hospitalization with discharged home in the last 12 months, or a scheduled office visit in the next 3 months).
4. Must speak English or Spanish
5. Able and willing to provide informed consent
Exclusion Criteria:
1. Meet the eligibility upper age limit during initial 4-month participation.
2. Have a prior history of lung cancer.
3. Have a new diagnosis of other cancers in the 12 months
4. Have a chest CT or LDCT in the last 12 months
5. Have ICD-10 code of Alzheimer's disease in EHR
About the study
Lung cancer screening (LCS) with low-dose computed tomography (LDCT) can reduce the risk of dying from lung cancer, but many people who are eligible for screening do not receive it. The purpose of the Empower LCS/Call+ study is to evaluate new strategies to improve lung cancer screening among adults who are eligible for screening based on current U.S. Preventive Services Task Force (USPSTF) guidelines.
This pilot randomized controlled trial will enroll approximately 80 participants from UC Irvine Health and Emory Healthcare. Participants will be randomly assigned to receive either enhanced usual care or the Empower LCS/Call+ intervention. The intervention includes educational materials, reminders for patients and primary care providers, and information about financial and community resources when appropriate. Participants who do not complete lung cancer screening after the initial intervention may receive additional telephone-based navigation through the Call+ program to help identify and address barriers to screening and help with scheduling.
Participants will complete a baseline survey and follow-up surveys at 4 and 8 months, and researchers will review electronic health record information to determine whether lung cancer screening was discussed, ordered, and completed. Some participants will also be invited to complete a one-time interview about their experiences with the study.
The results of this study will help determine the feasibility, acceptability, and preliminary effectiveness of the Empower LCS/Call+ intervention and will inform future efforts to improve equitable access to lung cancer screening.
What is being tested
- Empower LCS (behavioral)
- Call+ Telephone Navigation (behavioral)
- Usual Care (other)
- Education (other)
Sponsor: University of California, Irvine · Participants: 80 · Started: Sep 16, 2026
Contact the study team
Official record on ClinicalTrials.gov — NCT07711691
Locations in the U.S.
| California | UCI Health Family Health Center - Anaheim, Anaheim
UCI Health - Costa Mesa, Costa Mesa
CHAO Family Comprehensive Cancer Center- Irvine, Irvine
UCI Health Gottschalk Medical Plaza, Irvine
UCI Health - Laguna Hills, Laguna Hills
UCI Health - Newport Beach MacArthur, Newport Beach
Primary Care & Internal Medicine Services, Orange
UCI Chao Family Comprehensive Cancer Center, Orange
UCI Health SeniorHealth Center -Pavillion 4, Orange
UCI Medical Center, Pavilion 3, Orange
UCI Health Family Health Center - Santa Ana, Santa Ana
UCI Health - Tustin, Tustin
UCI Health - Yorba Linda, Yorba Linda |
| Georgia | Emory at Avalon - Primary Care, Alpharetta (Not yet recruiting)
Emory Clinic at 1365 Clifton Road - Primary Care, Atlanta (Not yet recruiting)
Emory Clinic at 1525 Clifton Road - Primary Care, Atlanta (Not yet recruiting)
Emory Clinic at Midtown, Atlanta (Not yet recruiting)
Emory Clinic at Old Fourth Ward, Atlanta (Not yet recruiting)
Emory Gastroenterology, Atlanta (Not yet recruiting)
Emory at Northlake - Primary Care, Atlanta (Not yet recruiting)
Emory at Peachtree Hills - Primary Care, Atlanta (Not yet recruiting)
Emory at Toco Hills - Primary Care, Atlanta (Not yet recruiting)
Emory at Buford - Primary Care, Buford (Not yet recruiting)
Emory Clinic Downtown Decatur, Decatur (Not yet recruiting)
Emory Clinic at Decatur - Primary Care, Decatur (Not yet recruiting)
Emory at Decatur - Primary Care, Decatur (Not yet recruiting)
Emory at Decatur - Primary Care (Irvin Court), Decatur (Not yet recruiting)
Emory at Decatur - Primary Care (Scott Boulevard), Decatur (Not yet recruiting)
Emory at Flat Shoals - Primary Care, Decatur (Not yet recruiting)
Emory at Oak Grove - Primary Care, Decatur (Not yet recruiting)
Emory at Duluth, Duluth (Not yet recruiting)
Emory at Sugarloaf - Primary Care, Duluth (Not yet recruiting)
Emory Clinic at Saint Joseph's, Dunwoody (Not yet recruiting)
Emory at Dunwoody, Dunwoody (Not yet recruiting)
Emory at Findley Road, Johns Creek (Not yet recruiting)
Emory at Spivey Station - Primary Care, Jonesboro (Not yet recruiting)
Emory at LaGrange - Davis Road, La Grange (Not yet recruiting)
Emory at LaGrange - Smith Street - Primary Care, La Grange (Not yet recruiting)
Emory at Beaver Ruin - Primary Care, Lilburn (Not yet recruiting)
Emory at Mountain Park - Primary Care, Lilburn (Not yet recruiting)
Emory Clinic at Lithonia - Primary Care, Lithonia (Not yet recruiting)
Emory at Hillandale Family Medicine, Lithonia (Not yet recruiting)
Emory at Miller Grove - Primary Care, Lithonia (Not yet recruiting)
Emory at East Cobb - Primary Care, Marietta (Not yet recruiting)
Emory at Peachtree City - Primary Care, Peachtree City (Not yet recruiting)
Emory at Sharpsburg, Sharpsburg (Not yet recruiting)
Emory at Belmont - Primary Care, Smyrna (Not yet recruiting)
Emory at Centerville - Primary Care, Snellville (Not yet recruiting)
Emory at Snellville - Primary Care (Lenora Church Road), Snellville (Not yet recruiting)
Emory at Snellville - Primary Care (Oak Road), Snellville (Not yet recruiting)
Emory at Snellville Primary Care (Presidential Circle), Snellville (Not yet recruiting)
Emory at Eagles Landing Primary Care, Stockbridge (Not yet recruiting)
Emory at Rockbridge Primary Care & Nephrology, Stone Mountain (Not yet recruiting)
Emory at Stone Mountain - Primary Care, Stone Mountain (Not yet recruiting)
Emory at Tucker - Primary Care (1459 Montreal Road), Tucker (Not yet recruiting)
Pavilion Family Medicine Center, Warner Robins (Not yet recruiting)
Emory at West Point, West Point (Not yet recruiting) |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.