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Low Dose Radiotherapy for Osteoarthritis

A Prospective Study of Low Dose Radiotherapy for Osteoarthritis

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* 18 years or older
* Diagnosis of OA \>3 months in hips, knees, hands, shoulders, ankles or elbows.
* Refractory to standard of care therapies for OA or those who are being considered for more aggressive interventional treatment such as joint replacement, but more conservative treatment is desired.
* Provision of signed and dated informed consent.

Exclusion Criteria:

* Unable to reasonably complete study instruments.

About the study

This single institution, multi-site, single arm prospective study will enroll patients with a history of OA and assess changes in pain and function after treatment with LDRT as measured by patient-reported outcomes.

What is being tested

• Low Dose Radiation Therapy (radiation)

Sponsor: Abramson Cancer Center at Penn Medicine · Participants: 113 · Started: Jun 24, 2026

Contact the study team

• Marlowe Estioko, BS, MS · Phone: 267-343-6483
• Sonya George, BS · Phone: 267-760-7636

Official record on ClinicalTrials.gov — NCT07715188

Locations in the U.S.

Conditions

• Osteoarthritis

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.