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AMAZE 9: A Research Study Investigating How Well Zenagamtide Tablets Help People With Excess Body Weight Lose Weight
RecruitingPhase 3
Efficacy and Safety of Once-daily Oral Zenagamtide in Participants With Obesity (AMAZE 9)
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria:
* Male or female (sex at birth).
* Age 18 and older (both inclusive) at time of signing the informed consent.
Exclusion Criteria:
* Glycated haemoglobin (HbA1c) more than or equal to (≥) 6.5% \[48 millimoles per mole (mmol/mol)\] as measured by the central laboratory at screening.
* History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records.
* Treatment with glucagon-like peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues before screening.
About the study
The purpose of this clinical study is to find out if zenagamtide is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as oral tablets once a day. Participants will either get zenagamtide (the treatment being tested) or Placebo (treatment that has no active medicine in it). Which treatment participants get is decided by chance.
What is being tested
- zenagamtide (drug)
- Placebo (drug)
Sponsor: Novo Nordisk A/S · Participants: 950 · Started: Aug 31, 2026
Contact the study team
Official record on ClinicalTrials.gov — NCT07720271
Locations in the U.S.
| Alabama | Pinnacle Research Group LLC, Anniston
Univ of Alabama Birmingham, Birmingham
Chambliss Clinical Trials LLC, Montgomery |
| California | Providence Medical Foundation, Fullerton
Torrance Clinical Research Institute, Inc., Lomita
Diablo Clinical Research, Inc., Walnut Creek |
| Colorado | Univ of Colorado at Denver, Aurora |
| Florida | Brain Matters Research, Delray Beach
Northeast Research Institute, Fleming Island
Miguel Rebollar PA, Hialeah
Jacksonville Ctr Clin Res, Jacksonville
South Broward Research LLC, Miramar
Clinical Neuroscience Solution, Orlando
Florida Institute for Clinical Research, LLC, Orlando
Oviedo Medical Research, LLC, Oviedo |
| Georgia | Hope Clin Res & Wellness, Conyers |
| Hawaii | East West Medical Research Institute_Honolulu, Honolulu |
| Illinois | Great Lakes Clinical Trials, Chicago
Clinical Investigation Spec Gurnee, Gurnee
Endeavor Health, Skokie
Evanston Premier Hlthcr Res, Skokie |
| Indiana | Midwest Inst For Clin Res, Indianapolis (Not yet recruiting) |
| Michigan | Northern Pines Hlth Ctr, PC, Buckley |
| Missouri | StudyMetrix Research LLC, City of Saint Peters |
| Nevada | Palm Research Center Inc., Las Vegas |
| New York | Comprehensive Weight Ctrl Prog, New York |
| North Carolina | Medication Mgmnt, LLC_Grnsboro, Greensboro
Accellacare of Raleigh, Raleigh
Accellacare-Salisbury PMG Res, Salisbury
Accellacare and KDCILM, LLC, Wilmington |
| Oklahoma | Lynn Institute of Norman, Norman |
| Rhode Island | Clinical Res Collaborative, Cumberland |
| South Carolina | Medical Uni of SC Charleston, Charleston
Coastal Carolina Research Ctr, North Charleston
Hillcrest Clinical Research, Simpsonville
Spartanburg Medical Research, Spartanburg |
| Texas | Amarillo Medical Specialists, Amarillo
North Texas Endocrine Center, Dallas |
| Virginia | Washington Cntr Weight Mgmt, Arlington (Not yet recruiting)
Health Res of Hampton Roads, Newport News
National Clin Res Inc., Richmond |
Conditions
From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.