PCOS and Brain Health

Inclusion Criteria (Participants with PCOS):

* Rotterdam criteria demonstrating two out of the three criteria. These are:

  1. Presence of clinical hyperandrogenism or biochemical hyperandrogenism
  2. A history of irregular menstrual cycles
  3. Presence of polycystic ovarian morphology on ultrasound

Inclusion Criteria (Healthy Controls):

* Regular menstrual cycles (not meeting criteria for irregular cycles above)
* No diagnosis of PCOS
* Controls may have isolated hirsutism or polycystic ovaries on ultrasound as long as they do not meet Rotterdam criteria for PCOS

Exclusion Criteria:

* Current pregnancy
* Preexisting diagnosis of type 1 diabetes
* Severe obesity (body mass index (BMI) greater than 45kg/m2)
* Preexisting diagnosis of hypertension requiring antihypertensive medication or blood pressure of greater than 160/100 on two separate occasions during clinical care
* History of neurologic disease or stroke
* History of myocardial infarction or deep venous thrombosis
* Endometriosis confirmed by prior laparoscopy
* Autoimmune conditions including lupus, multiple sclerosis, and active malignancy
* Immuno-modulating medications
* Conditions incompatible with MRI scanning, including but not limited to

  * Certain implanted metal devices or foreign bodies
  * Severe claustrophobia
* Post-menopausal
* Participants will be excluded if they have taken hormonal contraception or fertility medication in the last month