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Decoding the Neural Mechanisms Underlying Postural Instability and Gait Dysfunction in Parkinson's Disease

Recruiting

Who can join

Ages 18 and older · All sexes

Full eligibility criteria
Inclusion Criteria:

* You have been diagnosed with Parkinson's disease
* You already have a deep brain stimulation (DBS) device implanted as part of your medical care - specifically, the Medtronic Percept DBS device
* Your DBS settings have been stable for at least 3 months
* You experience freezing of gait (sudden inability to move your feet when trying to walk)
* You are able to walk on your own for at least 10 minutes without assistance
* You are willing to temporarily stop your Parkinson's medications and have your DBS settings adjusted for study testing
* You are able to understand the study and provide consent to participate

Exclusion Criteria:

* You have a neurological condition other than Parkinson's disease (such as stroke or multiple sclerosis)
* You have been diagnosed with dementia or have difficulty understanding the study or giving consent
* You currently have alcohol or substance abuse problems
* You have hearing or vision problems that would make it difficult to use a virtual reality headset
* You have any medical or mental health condition that, in the opinion of the study doctor, would make it unsafe or difficult for you to participate

About the study

The purpose of this study is to learn how brain signals are related to freezing of gait (FOG) and balance problems in Parkinson's disease (PD) and to study how different deep brain stimulation (DBS) settings may affect these symptoms.

What is being tested

Sponsor: The Cleveland Clinic · Participants: 5 · Started: Dec 9, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT07748962

Locations in the U.S.

OhioCleveland Clinic, Cleveland

Conditions

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.