Radiation Therapy Approaches for People With Prostate Cancer

RecruitingPhase 2

Balancing Radiation Intensification and Quality of Life in Higher-Risk Prostate Cancer (The BALANCE-RT Trial)

Who can join

All ages · All sexes

Full eligibility criteria

Inclusion Criteria:

* Non-metastatic prostate cancer.
* Classified as unfavorable intermediate-, high-, or very high-risk prostate cancer according to NCCN risk stratification guidelines. (Note: cT3a or T3b by MRI or PSMA PET allowed)
* Considered by the treating radiation oncologist as a suitable candidate for both HDR brachytherapy boost and SBRT

Exclusion Criteria:

* None

About the study

The purpose of the study is to explore the best ways of giving radiation therapy to balance cancer control and treatment side effects.

What is being tested

Standard of Care HDR Brachytherapy (radiation)
SBRT (radiation)

Sponsor: Memorial Sloan Kettering Cancer Center · Participants: 126 · Started: Jul 31, 2026

Contact the study team

Daniel Gorovets, MD · Phone: 212-639-3983
Himanshu Nagar, MD · Phone: 212-639-6478

Official record on ClinicalTrials.gov — NCT07751159

Locations in the U.S.

New Jersey	Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities), Basking Ridge Memorial Sloan Kettering at Monmouth (Limited Protocol Activities), Middletown Memorial Sloan Kettering at Bergen (Limited Protocol Activities), Montvale
New York	Memorial Sloan Kettering Suffolk-Commack (Limited Protocol Activities), Commack Memorial Sloan Kettering at Westchester (Limited Protocol Activities), Harrison Memorial Sloan Kettering Cancer Center (All Protocol Activites), New York Memorial Sloan Kettering at Nassau (Limited Protocol Activities), Uniondale

Conditions

Prostate Cancer

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.