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Allogeneic iNKT Cell Therapy (agenT-797) After SCT

RecruitingPhase 1

UW26004: Phase I Trial of Allogeneic iNKT Cell Therapy (agenT-797) in Patients Undergoing Allogeneic Hematological Stem Cell Transplantation (SCT)

Who can join

Ages 18 and older · All sexes

Full eligibility criteria
Inclusion Criteria:

* Age ≥18 years at the time of consent
* Adult patients anticipated to get an allogeneic hematopoietic cell transplantation (allo-SCT)
* All donor types are accepted (MMUD \[mismatched unrelated donor\], MUD \[matched unrelated donor\], MSD \[matched sibling donor\], haploidentical)
* All conditioning regimens will be accepted (MAC \[myeloablative conditioning\], RIC \[reduced-intensity conditioning\], NMAC \[non-myeloablative conditioning\])
* Karnofsky Performance Scale (KPS) \> 70
* Eligible Diagnoses:

  * Acute myeloid leukemia (AML) with intermediate/high-risk features or relapsed disease
  * Chronic myeloid leukemia (CML) in accelerated or blast phases
  * Myelodysplastic syndrome (MDS) with intermediate/high-risk features
  * Acute lymphoblastic leukemia (ALL) with high-risk features or relapsed disease
  * or any patients undergoing allogeneic stem cell transplant (allo-SCT) as standard of care could be eligible

Exclusion Criteria:

* Excluded Diagnoses: Primary Myelofibrosis in the dose escalation phase and could be included in the dose-expansion phase

About the study

The goal of this clinical trial is to learn if agenT-797 is safe to use on people undergoing allogenic hematological stem cell transplantation (SCT). The main questions it aims to answer are:

* Is agenT-797 safe to use? * What medical problems do participants have when taking agenT-797?

Participants will receive an infusion of agenT-797 about 7 days after their allogenic SCT.

What is being tested

Sponsor: University of Wisconsin, Madison · Participants: 22 · Started: 2026-11

Contact the study team

Official record on ClinicalTrials.gov — NCT07758218

Locations in the U.S.

WisconsinUniversity of Wisconsin - Madison, Madison

Conditions

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.