Home › Drug Resistant Epilepsy › NCT07764718

Temporal Interference Brain Stimulation for Adults With Drug-Resistant Epilepsy Undergoing Stereo-EEG Monitoring

Temporally Interfering Electric Field Stimulation in the Treatment of Epilepsy - Effect of Temporal Interference on Biomarkers of Epilepsy

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Adult patients with focal DRE who will undergo presurgical evaluation with sEEG
* Availability of at least one sEEG electrode inserted into the thalamus for clinical purposes
* sEEG performed with the indication to identify one single epileptic focus
* Ability to provide written informed consent and comply with the study protocol

Exclusion Criteria:

\- Remote resective/ablative brain surgery

About the study

This study evaluates whether a non-invasive brain stimulation technique called Temporal Interference (TI) can reduce epilepsy-related abnormal brain activity and influence sleep-related brain rhythms in adults with focal drug-resistant epilepsy undergoing stereo-EEG monitoring for clinical care. Up to 30 participants will complete stimulation sessions during wakefulness and, when possible, natural non-REM sleep. Brain activity will be recorded using scalp EEG and implanted sEEG electrodes before, during, and after TI stimulation. Some participants may also receive subthreshold direct stimulation through implanted electrodes for comparison. The study aims to determine whether TI can reduce epilepsy biomarkers, alter sleep-related brain activity, and compare favorably with conventional direct electrical stimulation while remaining within established safety limits.

What is being tested

• Temporal Interference Stimulation (device)
• Direct Electrical Stimulation (device)

Sponsor: Duke University · Participants: 30 · Started: Sep 16, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT07764718

Locations in the U.S.

Conditions

• Drug Resistant Epilepsy

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.