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Drug Resistant Epilepsy clinical trials recruiting in the U.S.

19 studies for Drug Resistant Epilepsy are recruiting participants at sites across the United States.

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Recently updated studies

Sleep-Sensitive Seizure Risk Assessment With Wearable EEGs

Recruiting
Ages 18 and older · All sexes · Updated Oct 19, 2026 · NCT06545643

Overnight TI in TLE

Recruiting
Ages 18 to 70 · All sexes · Updated Oct 16, 2026 · NCT07434986

Optimization of Deep Brain Stimulation Parameters in Patients With Medically Refractory Epilepsy

RecruitingEarly phase 1
Ages 18 and older · All sexes · Updated Oct 16, 2026 · NCT05493722

Post-Market Real-World Evidence Registry for the NeuroOne OneRF® Ablation System for Epilepsy

RecruitingObservational study
All ages · All sexes · Updated Oct 16, 2026 · NCT07546253

Temporal Interference Brain Stimulation for Adults With Drug-Resistant Epilepsy Undergoing Stereo-EEG Monitoring

Recruiting
Ages 18 and older · All sexes · Updated Oct 15, 2026 · NCT07764718

Pediatric Epilepsy

Recruiting
Ages 3 to 25 · All sexes · Updated Oct 6, 2026 · NCT07350551

Optimizing Therapy in Epilepsy Using Seizure Forecasts Via EEG and Wearables

RecruitingEarly phase 1Mentions payment for participants
Ages 18 to 75 · All sexes · Updated Sep 25, 2026 · NCT07012148

Neural Mechanisms of Spatial Representations Beyond the Self

Recruiting
Ages 18 to 70 · All sexes · Updated Jul 27, 2026 · NCT05406349

VNS Algorithm for Advanced Dosing

Recruiting
Ages 18 to 75 · All sexes · Updated Jul 24, 2026 · NCT07725601

Non-Invasive Low Intensity Focused Ultrasound Stimulation for Drug-Resistant Epilepsy

Recruiting
Ages 21 to 65 · All sexes · Updated Jul 2, 2026 · NCT07680842

Low Intensity Focused Ultrasound Epilepsy: A Pilot Trial

Recruiting
Ages 18 and older · All sexes · Updated Jun 18, 2026 · NCT03868293

Characterization and Analysis of Evoked Cortical Responses in Participants With Medication-intractable Epilepsy

Recruiting
Ages 22 to 75 · All sexes · Updated Jun 8, 2026 · NCT07014592

Self-administered ONe-of-a Kind Approach to Epilepsy Therapy Through a Web-based Music Application

Recruiting
Ages 18 and older · All sexes · Updated May 20, 2026 · NCT06425029

Spatial Scene Recognition Memory in Epilepsy Surgery

RecruitingHealthy volunteers welcome
Ages 18 to 55 · All sexes · Updated May 12, 2026 · NCT07580183

Localizing Epileptic Networks Using MRI and iEEG

RecruitingEarly phase 1Healthy volunteers welcome
Ages 18 and older · All sexes · Updated Feb 13, 2026 · NCT04649008

Infrared Photobiomodulation in Humans With Epilepsy

Recruiting
Ages 18 and older · All sexes · Updated Feb 4, 2026 · NCT07145489

Diffusion Tensor and Functional Connectivity Imaging in Pediatric Epilepsy: Imaging/Histology Correlation

Recruiting
0 Days – 18 Years · All sexes · Updated Dec 11, 2024 · NCT02846272

Network Effects of Therapeutic Deep Brain Stimulation

Recruiting
Ages 18 and older · All sexes · Updated Oct 31, 2022 · NCT05600738

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.