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Drug Resistant Epilepsy clinical trials recruiting in the U.S.
19 studies for Drug Resistant Epilepsy are recruiting participants at sites across the United States.
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Recently updated studies
Optimizing Therapy in Epilepsy Using Seizure Forecasts Via EEG and Wearables
RecruitingEarly phase 1Mentions payment for participants
Ages 18 to 75 · All sexes · Updated Sep 25, 2026 · NCT07012148A Safety, Tolerability, and Preliminary Efficacy of Low-intensity Focused Ultrasound Neuromodulation in Patients With Drug-resistant Epilepsy
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT06388707A Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy
RecruitingPhase 2/3
Ages 18 to 75 · All sexes · Updated Aug 24, 2026 · NCT06132893Neural Mechanisms of Spatial Representations Beyond the Self
Recruiting
Ages 18 to 70 · All sexes · Updated Jul 27, 2026 · NCT05406349VNS Algorithm for Advanced Dosing
Recruiting
Ages 18 to 75 · All sexes · Updated Jul 24, 2026 · NCT07725601Ketogenic Diet for Prevention of Epileptic Spasms in Infantile Onset Genetic Epilepsies
RecruitingPhase 1
0 Days – 9 Months · All sexes · Updated Jul 6, 2026 · NCT06700811Non-Invasive Low Intensity Focused Ultrasound Stimulation for Drug-Resistant Epilepsy
Recruiting
Ages 21 to 65 · All sexes · Updated Jul 2, 2026 · NCT07680842Low Intensity Focused Ultrasound Epilepsy: A Pilot Trial
Recruiting
Ages 18 and older · All sexes · Updated Jun 18, 2026 · NCT03868293Characterization and Analysis of Evoked Cortical Responses in Participants With Medication-intractable Epilepsy
Recruiting
Ages 22 to 75 · All sexes · Updated Jun 8, 2026 · NCT07014592Sleep-Sensitive Seizure Risk Assessment With Wearable EEGs
Recruiting
Ages 18 and older · All sexes · Updated Jun 5, 2026 · NCT06545643Self-administered ONe-of-a Kind Approach to Epilepsy Therapy Through a Web-based Music Application
Recruiting
Ages 18 and older · All sexes · Updated May 20, 2026 · NCT06425029Spatial Scene Recognition Memory in Epilepsy Surgery
RecruitingHealthy volunteers welcome
Ages 18 to 55 · All sexes · Updated May 12, 2026 · NCT07580183Localizing Epileptic Networks Using MRI and iEEG
RecruitingEarly phase 1Healthy volunteers welcome
Ages 18 and older · All sexes · Updated Feb 13, 2026 · NCT04649008Infrared Photobiomodulation in Humans With Epilepsy
Recruiting
Ages 18 and older · All sexes · Updated Feb 4, 2026 · NCT07145489ESIS in Pediatric DRE
RecruitingObservational study
Ages 1 to 30 · All sexes · Updated Dec 23, 2025 · NCT05469373Optimization of Deep Brain Stimulation Parameters in Patients With Medically Refractory Epilepsy
RecruitingEarly phase 1
Ages 18 and older · All sexes · Updated Oct 24, 2025 · NCT05493722Goals for Epilepsy Clinic Visits Trial
Recruiting
Ages 18 and older · All sexes · Updated Oct 20, 2025 · NCT05928598Diffusion Tensor and Functional Connectivity Imaging in Pediatric Epilepsy: Imaging/Histology Correlation
Recruiting
0 Days – 18 Years · All sexes · Updated Dec 11, 2024 · NCT02846272Network Effects of Therapeutic Deep Brain Stimulation
Recruiting
Ages 18 and older · All sexes · Updated Oct 31, 2022 · NCT05600738From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.