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Alcohol, Breast Cancer, and Metabolism
Localized Mammary Alcohol Metabolism as a Mechanism Linking Low-Level Alcohol Intake to Breast Cancer Risk
Who can join
Ages 21 to 45 · Women · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: All aims -Drink alcohol (at least one alcoholic drink during lactation of a lactating female) For aims 1 and 2 * Nursing a 2- to 5-month-old infant * Experienced with a breast pump Exclusion Criteria: * Pregnant * Lifetime history of alcohol dependence * Drink more than 3 standard drinks per day or more than 7 standard drinks per week in the month previous to enrollment * Current regular use of drugs with addiction potential (other than alcohol) * Use of medications known to interact with alcohol metabolism * Current smoking * Anemia * Diabetes * Liver disease
About the study
Alcohol consumption, even at low levels, has been associated with increased breast cancer risk, but the biological mechanisms underlying this relationship remain unclear. This study will examine whether breast tissue may locally metabolize alcohol by measuring alcohol-related compounds in paired blood and breast milk samples from lactating women. The findings may help clarify alcohol-related biological pathways relevant to breast cancer risk and improve risk communication.
What is being tested
- Low-alcohol level exposure (other)
- Breast-pumping time (other)
Sponsor: University of Illinois at Urbana-Champaign · Participants: 50 · Started: Sep 3, 2026
Contact the study team
- Marta Y Pepino de Gruev, Ph D · Phone: 217-300-2374
Official record on ClinicalTrials.gov — NCT07779967
Locations in the U.S.
| Illinois | Bevier Hall; University of Illinois at Urbana Champaign, Urbana |
Conditions
From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.