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Long-Term Study of COVID-19 Infection and Long COVID
Longitudinal Study of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and Post-Acute Sequelae of COVID-19 (PASC)
Who can join
Ages 18 to 75 · All sexes
Full eligibility criteria
Inclusion Criteria: * Age 18 to 75 years. * Previous laboratory-confirmed SARS-CoV-2 infection. * Willing and able to provide informed consent. * Able to complete study questionnaires and study procedures. Exclusion Criteria: * Current severe periodontal disease with bleeding gums. * Current oral herpes flare, aphthous ulcer, or oral candidiasis (thrush). * Oral viral or bacterial infection within the previous 30 days. * Dry mouth that would prevent adequate saliva collection. * Active alcohol or drug abuse. * Medical or genetic syndrome or developmental delay that would prevent completion of study procedures or questionnaires.
About the study
This study will examine how common Long COVID is and how symptoms may persist over time in people who have previously had COVID-19. Researchers will collect information about participants' health and symptoms through questionnaires and may collect saliva and other non-invasive oral samples. The study will also examine biological factors in these samples that may be associated with persistent symptoms. The goal is to better understand why some people develop Long COVID and identify factors that may help predict who is more likely to experience persistent symptoms.
What is being tested
- This study is observational. Only patients who have previously tested positive for SARS-CoV-2 infection or are experiencing ongoing symptoms. (other)
Sponsor: University of North Carolina, Chapel Hill · Participants: 500 · Started: Sep 4, 2024
Contact the study team
- Laura A Jacox, PhD, DMD, MS · Phone: +1 847-702-0988
- Jeannene L Matthews, MA, M.Ed., CCC-SLP · Phone: +1 919-907-9685
Official record on ClinicalTrials.gov — NCT07781501
Locations in the U.S.
| North Carolina | University of North Carolina, Chapel Hill |
Conditions
From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.