A Study to Evaluate the Long-term Safety and Efficacy of Lunsekimig in Adult Participants With Chronic Obstructive Pulmonary Disease (COPD)

Inclusion Criteria:

* Participants who completed the treatment period of EFC18243 or EFC18244 studies, including EOI visit
* Contraception for male and female participants during the study intervention period and during 8 weeks following the last administration of study intervention. And:

  * Female participants: not pregnant or breastfeeding, and one of the following conditions applies:

    * Is not a women of childbearing potential (WOCBP), OR
    * Is a WOCBP and agrees to follow the contraceptive guidance. The WOCBP should also agree not to donate or cryopreserve eggs (ova, oocytes) for the purpose of reproduction.
  * Male participants: No sperm donation or cryopreserving sperm

ICS-withdrawal sub-study only:

* Participants receiving triple controller therapy (LABA+LAMA+ICS)
* Participants who were compliant with lunsekimig
* ≤ 1 moderate exacerbation and no severe exacerbation of COPD during the parent study
* No exacerbation during the run-in period

Exclusion Criteria:

The exclusion criteria are identical for LTS18211 and ICS withdrawal sub-study:

* Participant who developed a new medical condition or a change in status of an established medical condition or requires a new treatment or medication prior to enrollment that, per Investigator's medical judgement, would adversely affect participation of the participant in this study or would require permanent lunsekimig discontinuation, or participant potentially at risk of noncompliance to study procedures
* Prescription drug or substance abuse, including alcohol, considered significant by the Investigator
* History of hypersensitivity or allergy to lunsekimig or to any of the excipients used in the presentation or in preparation for administration of lunsekimig, or other allergy that, in the opinion of the Investigator, contraindicates participation in the study
* Participants who are receiving prohibited concomitant medications at LTS18211 baseline
* Participants who, during their participation in the parent study, developed an AE or an SAE deemed related to lunsekimig, and for whom continuation of treatment with lunsekimig may present an unreasonable risk

The above information is not intended to contain all considerations relevant to a participant's potential participation in a clinical trial.