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COPD clinical trials recruiting in the U.S.
100 studies for COPD are recruiting participants at sites across the United States.
COPD (chronic obstructive pulmonary disease) makes it hard for you to breathe. At first symptoms are mild, but they usually become more severe. Learn more.
Cities with the most studies
- Philadelphia, PA26 studies
- Miami, FL20 studies
- Houston, TX18 studies
- Birmingham, AL17 studies
- Baltimore, MD16 studies
- Boston, MA15 studies
- Orlando, FL15 studies
- Chicago, IL15 studies
- Dallas, TX13 studies
- New York City, NY12 studies
- Pittsburgh, PA11 studies
- Winston-Salem, NC11 studies
- Hialeah, FL10 studies
- Ann Arbor, MI10 studies
- Charlotte, NC10 studies
- Detroit, MI9 studies
- Phoenix, AZ9 studies
- Nashville, TN9 studies
- Los Angeles, CA9 studies
- Columbus, OH9 studies
- Kansas City, KS9 studies
- Milwaukee, WI8 studies
- Newport Beach, CA8 studies
- Cleveland, OH8 studies
- Tampa, FL8 studies
- West Palm Beach, FL8 studies
- Kendall, FL7 studies
- McKinney, TX7 studies
- St. Louis, MO7 studies
- Denver, CO7 studies
- Savannah, GA7 studies
- Indianapolis, IN6 studies
- Camden, NJ6 studies
- St. Petersburg, FL6 studies
- Atlanta, GA6 studies
- Shreveport, LA6 studies
- Aurora, CO6 studies
- Spartanburg, SC6 studies
- Las Vegas, NV6 studies
- Farmington Hills, MI6 studies
By state
- Alabama20 studies
- Arizona17 studies
- California27 studies
- Colorado15 studies
- Connecticut4 studies
- Florida31 studies
- Georgia14 studies
- Idaho4 studies
- Illinois20 studies
- Indiana11 studies
- Iowa6 studies
- Kansas13 studies
- Kentucky5 studies
- Louisiana10 studies
- Maine3 studies
- Maryland18 studies
- Massachusetts24 studies
- Michigan23 studies
- Minnesota11 studies
- Mississippi3 studies
- Missouri10 studies
- Montana3 studies
- Nebraska5 studies
- Nevada9 studies
- New Jersey8 studies
- New York23 studies
- North Carolina24 studies
- Ohio18 studies
- Oklahoma9 studies
- Oregon7 studies
- Pennsylvania33 studies
- South Carolina17 studies
- South Dakota7 studies
- Tennessee16 studies
- Texas28 studies
- Utah7 studies
- Vermont5 studies
- Virginia12 studies
- Washington8 studies
- West Virginia5 studies
- Wisconsin9 studies
Recently updated studies
A Study to Investigate the Efficacy and Safety of GSK5784283 (Felcorekibart) Compared With Placebo in Participants With Moderate to Very Severe COPD (PERSIST COPD-1)
RecruitingPhase 3
Ages 40 to 80 · All sexes · Updated Nov 12, 2026 · NCT07780669Digital Inhaler Use in Obstructive Lung Disease Care
Recruiting
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT07214337A Study to Investigate the Efficacy and Safety of GSK5784283 (Felcorekibart) Compared With Placebo in Participants With Moderate to Very Severe COPD (PERSIST COPD-2)
RecruitingPhase 3
Ages 40 to 80 · All sexes · Updated Nov 12, 2026 · NCT07780656Feasibility of Noninvasive Trigeminal Nerve Stimulation During Exercise
RecruitingHealthy volunteers welcome
Ages 18 to 75 · All sexes · Updated Nov 12, 2026 · NCT07686302A Study of 24 to 52 Weeks Treatment to Evaluate The Efficacy And Safety of Galvokimig in Study Participants With Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD) With Chronic Bronchitis
RecruitingPhase 2
Ages 40 to 80 · All sexes · Updated Nov 6, 2026 · NCT07725939Ensifentrine (MK-5884) Study for the Prevention of Chronic Obstructive Pulmonary Disease (COPD) Exacerbations in Adults With a History of Moderate or Severe Exacerbations While Receiving Standard of Care (SOC) (MK-5884-031/RPL554/ENHANCE-3)
RecruitingPhase 3
Ages 40 to 80 · All sexes · Updated Nov 6, 2026 · NCT07874815A Study of Brenipatide (LY3537031) in Adult Participants With Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD)
RecruitingPhase 2
Ages 40 to 75 · All sexes · Updated Nov 5, 2026 · NCT07759245Evaluating the Safety and Efficacy of dNerva Lung Denervation System in Patients With COPD
Recruiting
Ages 40 to 80 · All sexes · Updated Nov 5, 2026 · NCT07051707WIN Ratio Analysis to Determine a Strategy of Non- Invasive SUpport for Respiratory Failure in the EmeRgency Department
Recruiting
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT07558265Rademikibart IV for Acute Asthma and COPD Exacerbation
RecruitingPhase 2
Ages 18 to 85 · All sexes · Updated Nov 4, 2026 · NCT07705737A Study to Investigate the Efficacy and Safety of Zelicapavir Compared With Placebo in Adults With RSV Who Are at High Risk for Severe Disease
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Nov 2, 2026 · NCT07908381To Evaluate the Effect of EXPD-101/FXS7553 Compared With Placebo in Patients With COPD Over 52 Weeks of Treatment
RecruitingPhase 2
Ages 40 to 85 · All sexes · Updated Oct 28, 2026 · NCT07684820Rehabilitation in Safety-net Environments (RISE) to Improve Outcomes in Vulnerable Patients With COPD
Recruiting
Ages 40 to 90 · All sexes · Updated Oct 27, 2026 · NCT05572632Genetic Variation in IgG in Alpha 1 Antitrypsin Deficiency
RecruitingPhase 4
Ages 19 and older · All sexes · Updated Oct 27, 2026 · NCT07135427A Non-inferiority Pharmacokinetic and Safety/Tolerability Study of Two Different Doses of Weekly SC Alpha1-PI 15% Compared With Corresponding Standard IV Alpha1-PI in Participants With Alpha1-Antitrypsin Deficiency (AATD)
RecruitingPhase 3
Ages 18 to 80 · All sexes · Updated Oct 26, 2026 · NCT07555483A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease
RecruitingPhase 2
Ages 40 and older · All sexes · Updated Oct 23, 2026 · NCT07082738Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD), Characterized by an Eosinophilic Phenotype
RecruitingPhase 3
Ages 40 to 80 · All sexes · Updated Oct 23, 2026 · NCT07190222A Study of WIN378 in Participants With Moderate to Severe COPD (Sirius)
RecruitingPhase 2
Ages 40 to 80 · All sexes · Updated Oct 23, 2026 · NCT07646587Collection of Airway, Blood and/or Urine Specimens From Subjects for Research Studies
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Oct 23, 2026 · NCT01776398A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate to Severe Chronic Obstructive Pulmonary Disease
RecruitingPhase 2/3
Ages 35 to 80 · All sexes · Updated Oct 22, 2026 · NCT07363694A Study to Investigate Airway Inflammation With Dupilumab Subcutaneously in Participants Aged ≥40 to ≤85 Years With Chronic Obstructive Pulmonary Disease.
RecruitingPhase 4
Ages 40 to 85 · All sexes · Updated Oct 20, 2026 · NCT07053423Compare the Effects of Nebulizer Versus Inhaler Based Therapy for COPD Using Long-acting Bronchodilators
RecruitingPhase 4
Ages 40 and older · All sexes · Updated Oct 19, 2026 · NCT07133880Bronchoscopic RElease of Air Trapped in Hyperinflated Emphysematous Lung - Study 3
Recruiting
Ages 40 to 84 · All sexes · Updated Oct 19, 2026 · NCT06891755Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD) Characterized by an Eosinophilic Phenotype
RecruitingPhase 3
Ages 40 to 80 · All sexes · Updated Oct 19, 2026 · NCT07190209The Increase of Lung Capacity Using the Lung Master (Pulmonary Exerciser)
RecruitingHealthy volunteers welcome
Ages 19 and older · All sexes · Updated Oct 19, 2026 · NCT06524856From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.