Home › Traumatic Brain Injury › NCT07794605

Sleep to Predict Recovery In Unconscious Patients With Acute Brain Injury

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

\- Adults with non-penetrating traumatic brain injury (TBI) or with primary intracerebral hemorrhage (ICH) (i.e. from hypertension or anticoagulants) who remain behaviorally unresponsive to verbal commands (i.e., comatose vegetative state, or minimally conscious state minus \[MCS-minus, defined as unresponsive with preserved visual fixation/pursuit or localization to noxious stimuli\]) by day 2 after injury

Exclusion Criteria:

* Evidence of consciousness within 2 days of injury
* Uncontrolled seizures
* pre-existing disorders of consciousness
* deafness

About the study

Severe brain injuries can leave people in states where they are unconscious or only partly aware, such as a coma. These conditions are common after injuries like head trauma or bleeding in the brain. One of the biggest challenges for doctors is knowing if - or when - a patient will wake up and regain awareness.

This research study is being done to determine if patterns in brain activity during sleep (measured by EEG) can help doctors better predict how quickly someone will wake up and recover after a serious brain injury, as well as how well they might do in the long term. It also aims to develop new ways of using EEG to track how the brain's networks heal and reconnect over time.

Sponsor: Columbia University · Participants: 230 · Started: Oct 30, 2026

Contact the study team

• Jan Claassen, MD · Phone: 212-305-7236
• Angela Velazquez, MD · Phone: 212-305-6071

Official record on ClinicalTrials.gov — NCT07794605

Locations in the U.S.

Conditions

• Traumatic Brain Injury
• Cerebral Hemorrhage

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.