Home › Quitting Smoking (Tobacco Use Disorder) › NCT07812753
Modulating Neural Mechanisms of Reward Processing in Tobacco Users
Who can join
Ages 18 to 60 · All sexes
Full eligibility criteria
Inclusion Criteria: * Be between the ages of 18 and 60 years old * Smoke 10 or more cigarettes per day and have a carbon monoxide (CO) level greater than 10 ppm indicative of recent smoking * Have not received substance abuse treatment within the previous 30 days * Meet criteria for Tobacco Use Disorder as determined by the Mini International Neuropsychiatric Interview (MINI): meeting 4 or more of the 11 diagnostic symptoms of Tobacco Use Disorder within a 12-month period * If female, test non-pregnant * Show no evidence of focal or diffuse brain lesions on MRI * Be willing to provide informed consent * Be able to comply with protocol requirements and likely to complete all study procedures * Be motivated to quit smoking, based on a response of "very likely" or "somewhat likely" on the Motivation to Stop Scale (scores 4-7) Exclusion Criteria: * Meeting MINI diagnostic criteria for any non-tobacco substance use disorder other than Caffeine Use Disorder, Cannabis Use Disorder - Mild, or Alcohol Use Disorder - Mild (Mild defined as meeting 2 to 3 of the 11 diagnostic symptoms within a 12-month period) * Contraindications to MRI (e.g., metal in the skull, orbital, or intracranial cavity, or claustrophobia) * Contraindication to repetitive TMS * History of autoimmune, endocrine, viral, or vascular disorders affecting the brain * History or MRI evidence of a neurological disorder causing local or diffuse brain lesions or significant physical impairment * Unstable cardiac disease, uncontrolled hypertension, severe renal or liver insufficiency, or sleep apnea * Lifetime history of major Axis I disorders as confirmed by the MINI, including bipolar affective disorder, schizophrenia, post-traumatic stress disorder, suicidal ideation, or major depression * Current use of tobacco cessation pharmacotherapies, including nicotine patches, electronic cigarettes, gum, nasal spray, inhalers, nicotine lozenges, varenicline, or bupropion * Previous treatment with TMS
About the study
The goal of this clinical trial is to learn if a personalized, brain-scan-guided form of transcranial magnetic stimulation (TMS) works better than a standard TMS approach at changing reward-related brain activity in adults who smoke cigarettes. The main questions it aims to answer are:
Does personalized TMS produce a greater change in reward-related brain activity than the standard approach? Does personalized TMS lead to a greater reduction in cravings and cigarette smoking than the standard approach?
Researchers will compare personalized TMS, which targets a treatment location chosen from each participant's own brain scan, to a standard TMS approach, which targets a location based on anatomical landmarks, to see if the personalized approach produces stronger effects on brain reward activity and smoking behavior.
Participants will:
Complete an magnetic resonance imaging (MRI) brain scan and questionnaires about their smoking habits and mood Be randomly assigned to receive either personalized TMS or the standard TMS approach Attend 15 TMS treatment sessions over 3 weeks (Monday through Friday), including brain wave (EEG) recordings and craving check-ins before and after each session Return for follow-up visits 1 week and 1 month after finishing treatment
What is being tested
- PRIME TMS (device)
- Standard TMS (device)
Sponsor: Rutgers, The State University of New Jersey · Participants: 54 · Started: Jul 24, 2026
Contact the study team
- TRAVIS BAKER, PhD · Phone: 9733533385
Official record on ClinicalTrials.gov — NCT07812753
Locations in the U.S.
| New Jersey | Rutgers University Center for Molecular and Behavioral Neuroscience, Newark |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.