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CT- Versus MRI-Based Planning for High-Dose-Rate Prostate Brachytherapy for Prostate Cancer
A Randomized Pragmatic Study of CT- Versus MRI-Based Planning for High-Dose-Rate Prostate Brachytherapy for Prostate Cancer
Who can join
Ages 18 and older · Men
Full eligibility criteria
Inclusion Criteria: * Men ≥ 18 years old * Histopathologically confirmed prostate cancer * No evidence of regional or distant metastases * Plan to undergo curative-intent HDR brachytherapy with or without external beam radiation therapy Exclusion Criteria: * Prior pelvic radiation therapy * No prior prostate MRI
About the study
This clinical trial studies the safety of a computed tomography (CT) scan, with or without a magnetic resonance imaging (MRI) scan, in planning for high-dose-rate (HDR) prostate brachytherapy treatment in patients with prostate cancer. Brachytherapy is a type of radiation therapy in which radioactive implants, such as pellets, seeds, ribbons, wires, needles, balloons, or capsules, are placed in the body, directly into or near the tumor. The radiation is delivered through a flexible tube called a catheter or a larger device called an applicator. Treatment planning, or simulation, is a process used to plan radiation therapy so that the target area is precisely located and marked. A CT scan is a procedure that uses a computer linked to an x-ray machine to make a series of detailed pictures of areas inside the body. The pictures are taken from different angles and are used to create 3-dimensional views of tissues and organs. An MRI is a procedure in which radio waves and a powerful magnet linked to a computer are used to create detailed pictures of areas inside the body. The addition of MRI to CT for HDR prostate brachytherapy treatment planning may help patients have less urine leakage and less pain after treatment.
What is being tested
- Magnetic Resonance Imaging (procedure)
- Questionnaire Administration (other)
Sponsor: Emory University · Participants: 100 · Started: Oct 22, 2026
Contact the study team
- Kamran Salari, MD · Phone: 404-686-2391
- Sagar Patel, MD · Phone: 404-778-1900
Official record on ClinicalTrials.gov — NCT07859722
Locations in the U.S.
| Georgia | Emory Proton Therapy Center, Atlanta Emory University Hospital Midtown, Atlanta Emory University Hospital/Winship Cancer Institute, Atlanta |
Conditions
From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.