Comparison of Two Pulse Field Ablation Systems for AF Ablation

Inclusion Criteria:

* Symptomatic AF
* Persistent AF
* De novo AF ablation
* Males and Females Age 18 to 89 years of age, inclusive
* Willing and capable to provide informed consent
* Able and willing to participate in all examinations and follow-up visits and tests associated with this clinical study

Exclusion Criteria:

* AF secondary to electrolyte imbalance, thyroid disease, alcohol abuse, or other reversible/non-cardiac causes
* Contraindication to, or unwillingness to use, systematic anticoagulation
* Left ventricular ejection fraction LVEF 30% as documented by TTE (within 3 months prior)
* Left atrial volume index \>60 ml/m2
* LA anteroposterior dimension 5.5 cm
* Presence of intramural thrombus, tumor or other abnormality that precludes safe catheter introduction or manipulation
* BMI \>35 kg/m2
* Chronic renal insufficiency of \<15 mL/min/1.73 m2 or any history of renal dialysis, or history of renal transplant
* Clinically significant systemic infection or sepsis
* Any of the following within the 3-months prior to enrollment:

  * Myocardial infarction
  * Unstable angina
  * Percutaneous coronary intervention
  * Heart failure hospitalization
  * Stroke or TIA
  * Significant bleeding
  * Pericarditis/effusions
  * Left atrial thrombus
  * Coronary artery bypass grafting/atriotomy within 6 months prior
  * Contraindication for oral anticoagulation
  * Organ or hematologic transplant, or currently being evaluated for an organ transplant Women who are pregnant or breastfeeding