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This Study is Comparing Pain Outcomes After Urethral Bulking When Participants Are Randomized to Two Different Pain Medication Regimens.

Lidocaine Jelly +/- Lidocaine Periurethral Injection for Urethral Bulking Analgesia: A Single-Blind Randomized Controlled Trial

Who can join

Ages 18 and older · Women

Inclusion Criteria:

* SUI based on +CST or UDS

Exclusion Criteria:

* contraindication to lidocaine, allergy to coaptite, pregnancy

About the study

We are doing this study to find the best way to manage pain during a procedure called urethral bulking. This procedure treats urine leakage that happens with coughing, laughing, sneezing, or physical activity. It works by injecting a gel-like substance around the urethra (the tube that urine comes out of) to help it stay closed when it should.

We use a numbing gel (called lidocaine jelly) inside the urethra to help with pain during the procedure. In this study, we will also be administering lidocaine (numbing medication) injected around the urethra or a saline placebo (medical grade saltwater) injection, which has no numbing effect. A placebo is something that looks like a real treatment but doesn't have any medical effect. Both the lidocaine and the saline would be injected around the urethra using a small needle, and we'll compare how well they work at reducing pain.

What is being tested

• Lidocaine injection (drug)
• Gyldo (drug)
• Saline (drug)

Sponsor: Northwell Health · Participants: 46 · Started: Oct 26, 2025

Contact the study team

• Carly Gridley Co-investigator, MD · Phone: 815-631-4840

Official record on ClinicalTrials.gov — NCT07889687

Locations in the U.S.

Conditions

• Pain

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.