Home › Major Depressive Disorder › NCT07891624
Neural Mechanisms of Real-world Emotions and Internalizing
Using High-stakes, Real-world Events to Map the Neural Dynamics Linked to Internalizing Disorders
Who can join
Ages 18 to 35 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Individuals who are between 18 - 35 years old. \[Reason: to be able to provide informed consent, and to minimize variation in functional and structural differences in brain\] * Individuals who are fluent English speakers. \[Reason: to understand study instructions \& questionnaires\] * Smart phone access. \[Reason: to answer the questionnaires that are administered throughout the study. Exclusion Criteria: * Women who are pregnant or breast feeding and are no more than six months post-partum. \[Reason: may be unsafe for fetus, may affect outcome measure(s)\] * Individuals who are excluded based on attached metal resonance Screening Form (Note: this form has already been approved by the Institutional Review Board (IRB for other protocols). \[Reason: necessary to participate in MRI research protocol\] * Individuals whose BMI is above 35. \[Reason: must fit into fMRI scanner\] * Individuals who have claustrophobia. \[Reason: to be able to stay in MRI scanner\] * Individuals who are unable, in the judgment of the investigator, to comply with directions and/or tolerate the procedures required for participation in this trial. \[Reason: to be able to understand instructions and ensure safety\] * Individuals who are unable to safely undergo MRI scanning. \[Reason: to be able to undergo MRI scanning\]
About the study
This study utilizes mobile health methods, including smartphone technology, subjective self-reports measures of emotion, behavioral tasks, functional Magnetic Resonance Imaging (fMRI), physiological measures of attention and arousal, and measures of health and social support to identify neural mechanisms associated with individual differences in the temporal course of emotional responses. The aim of this project is to utilize real-world and personally relevant events as stimuli to better understand how the temporal course of emotional responses relate to risk for developing mental disorders.
What is being tested
- Academic Performance Feedback (behavioral)
Sponsor: University of Miami · Participants: 144 · Started: Aug 24, 2026
Contact the study team
- Aaron S Heller, PhD · Phone: 305-284-9498
Official record on ClinicalTrials.gov — NCT07891624
Locations in the U.S.
| Florida | University of Miami, Coral Gables |
Conditions
From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.