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An Open Label Pilot Study Assessing the Impact of Chromium Picolinate Supplementation on Appetite and Cravings in Overweight Individuals
Who can join
Ages 35 to 70 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Males/Females age 35-70 years old, inclusive * Self-reported BMI between 25-31 kg/m² * In good general health at the time of screening (Investigator discretion, applied against the objective screening data and the exclusion criteria below - i.e., confirmation that no significant, unlisted comorbidity or acute condition is present that would confound assessment of appetite/craving outcomes or compliance), defined as medically stable for at least the last 6 months. * Self-reported weight stable, defined as body weight has not fluctuated significantly over the last 3 months. "Significantly" is defined as a change of more than 3% to 5% of total body weight, or a shift over 5 lbs (Pagidipati 2021) Moderate food cravings, defined as a score 25-54 on the Food Cravings Questionnaire -Reduced (FCQ-15) * Able to read and understand English. * Able to read, understand, and provide informed consent. * Able to use a personal smartphone device and download the Chloe app by People Science. * Able to receive shipment of the product and supplies at an address within the United States. * Able to complete study assessments over the course of up to 15 weeks. Exclusion Criteria: * Participants actively engaged in weight loss programs or actively dieting. * Participants taking any supplements (i.e. fat burners, etc.) specifically for weight loss/management (including appetite control) * Participants taking any cinnamon, berberine, or chromium containing supplements. * Do not have a personal smartphone, internet access, or unwilling to download Chloe. * Current or prior use of a GLP-1 within the last 2 weeks * Concomitant Therapies: Participants receiving any investigational therapies or treatments within 30 days prior to consent. * Other Illnesses or Conditions: Participants who have the following comorbidities or gastrointestinal illnesses are excluded: * Currently diagnosed with Alcohol Use Disorder and/or Substance Use Disorder * Currently diagnosed with an Eating Disorder * Currently pregnant, planning to become pregnant in the next 3 months, or breastfeeding * Any underlying medical conditions or comorbidities that may confound the assessment of digestive symptoms or the evaluation of the study outcomes. * Have a significant illness, disease or condition which, in the opinion of the principal investigator, may impact their ability to participate in the study or impact the study outcomes. * Known hypersensitivity or previous allergic reaction to chromium containing products. * Are unlikely for any reason to be able to comply with the trial or considered unsuited for participation in the study by the Principal Investigator.
About the study
This open-label, decentralized pilot study evaluates the effects of daily chromium picolinate supplementation (8 mg providing 1,000 mcg chromium) for 8 weeks on appetite, food cravings, and food-related intrusive thoughts ("food noise"). The study aims to enroll up to 110 evaluable healthy adults aged 35-70 years with a body mass index (BMI) between 25 and 31 kg/m². Participants are stratified into two cohorts: those without prior Glucagon-Like Peptide-1 (GLP-1) receptor agonist exposure (Cohort 1, n=80) and those with prior GLP-1 exposure following a 14-to-90-day washout period (Cohort 2, n=30).
Conducted entirely remotely via the Chloe mobile app, the study utilizes validated questionnaires (Food Cravings Questionnaire \[FCQ-T\], RAID-FN food noise inventory, appetite Visual Analogue Scales \[VAS\]), continuous glucose monitoring (CGM), daily meal logs, and weekly adverse event surveys to assess metabolic, behavioral, and subjective outcomes.
What is being tested
- Study Product (dietary supplement)
Sponsor: Nutrition 21, Inc. · Participants: 138 · Started: Aug 31, 2026
Contact the study team
- Megha Doshi, MD · Phone: 5626736744
- Lisa Capano-Wehrle · Phone: 8566931265
Official record on ClinicalTrials.gov — NCT07909109
Locations in the U.S.
| California | People Science, Los Angeles |
Conditions
From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.