Home › Traumatic Brain Injury › NCT07917728

Smartphone Enabled Detection of Cognitive Motor Dissociation in the ICU

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

1. Admitted for acute traumatic brain injury, intracerebral or subarachnoid hemorrhage, or cardiac arrest
2. Neurological examination per Coma Recovery Scale-Revised (CRS-R) criteria consistent with coma, vegetative state, or minimally conscious state minus (not explained by sedation)
3. Enrollment by day 7 post injury.

Exclusion Criteria:

1. EEG demonstrating ongoing seizures or ictal interictal continuum
2. Planned withdrawal of life sustaining therapy.

About the study

The purpose of this research study is to evaluate whether a smartphone-enabled EEG (electroencephalography) system can be used to detect Cognitive Motor Dissociation (CMD) in patients with acute neurological injuries who appear unable to follow commands at the bedside. CMD occurs when a person may be conscious and able to understand instructions but cannot physically respond. The study will also examine whether CMD detection is associated with short-term and long-term recovery outcomes.

Sponsor: Columbia University · Participants: 240 · Started: Oct 27, 2026

Contact the study team

• Jan Claassen, MD · Phone: 212-305-7236
• Angela Velazquez, MD · Phone: 212-305-6071

Official record on ClinicalTrials.gov — NCT07917728

Locations in the U.S.

Conditions

• Traumatic Brain Injury
• Cerebral Hemorrhage
• Subarachnoid Hemorrhage
• Sudden Cardiac Arrest

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.