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Iron Treatment for Iron Deficiency Anemia in Children and Young Adults With Crohn's Disease

Developing and Validating a Predictive Model for the Management of Iron Deficiency Anemia in Pediatric Crohn's Disease Through Analysis of Microbiome and Patient Laboratory Data

Who can join

Ages 3 to 21 · All sexes

Inclusion Criteria:

* Male or female
* 3 to 21 years of age
* Biopsy confirmed Crohns disease involving gastric, duodenal, and/or jejunal mucosa
* Quiescent Crohns disease, assessed by histopathology, CRP, ESR, and PCDAI scores
* Iron deficiency anemia, defined as hemoglobin or transferrin saturation below age-defined norms and/or MCV \<80.

Exclusion Criteria:

* antibiotic use with 6 weeks of endoscopic evaluation

About the study

Children and young adults with Crohn's disease may develop iron deficiency anemia, a condition in which low iron levels reduce the number of healthy red blood cells. This study aims to develop and test a model to help identify which iron treatment approached are most effective for these patients. Researchers will examine laboratory results, disease activity, treatment information, and information about bacteria in the digestive tract. Participants will be followed over time, and questionnaires will assess iron supplement use and related symptoms. The findings may help guide iron treatment for children and young adults with Crohn's disease.

What is being tested

• Iron (ferrous sulfate) (drug)

Sponsor: Weill Medical College of Cornell University · Participants: 150 · Started: Sep 13, 2023

Contact the study team

Official record on ClinicalTrials.gov — NCT07925450

Locations in the U.S.

Conditions

• Crohn's Disease
• Iron-Deficiency Anemia

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.