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Crohn's Disease clinical trials recruiting in the U.S.

89 studies for Crohn's Disease are recruiting participants at sites across the United States.

Crohn's Disease can cause inflammation in any area from the mouth to the anus. Read about medicines, surgery or dietary management to treat symptoms.

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Recently updated studies

Skeletal Health and Bone Marrow Composition in Newly Diagnosed Adolescents With Crohn Disease

RecruitingObservational studyHealthy volunteers welcome
Ages 13 to 20 · All sexes · Updated Nov 13, 2026 · NCT04508088

Testing of an Educational Tool for Patients With Melanoma and Pre-Existing Autoimmune Disease Who Are Candidates for Immune Checkpoint Inhibitors

RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT04751396

Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT03816345

A Study of SL-325 in Crohn's Disease Patients

RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Nov 12, 2026 · NCT07753850

Longitudinal Immunophenotyping of Patients With Inflammatory Bowel Disease

RecruitingObservational study
Ages 18 to 85 · All sexes · Updated Nov 10, 2026 · NCT07619547

Iron Treatment for Iron Deficiency Anemia in Children and Young Adults With Crohn's Disease

RecruitingPhase 4
Ages 3 to 21 · All sexes · Updated Nov 9, 2026 · NCT07925450

A Master Protocol (IIBD): A Study of Multiple Drugs in Adults With Ulcerative Colitis or Crohn's Disease

RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Nov 4, 2026 · NCT07483073

A Phase 2 Study to Evaluate MORF-057 in Adults With Moderately to Severely Active Crohn's Disease

RecruitingPhase 2
Ages 18 to 85 · All sexes · Updated Nov 4, 2026 · NCT06226883

A Study of LY4395089 and Mirikizumab (LY3074828) Given Together and Mirikizumab (Alone) in Adults With Crohn's Disease

RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Nov 4, 2026 · NCT07483099

A Study of Icotrokinra in Participants With Moderately to Severely Active Crohn's Disease

RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT07196722

A Study of JNJ-78934804 in Participants With Moderately to Severely Active Crohn's Disease

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT07577843

A Long-term Extension (LTE) Study of Guselkumab in Pediatric Participants

RecruitingPhase 3
Ages 3 and older · All sexes · Updated Nov 3, 2026 · NCT06663332

A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Crohn's Disease

RecruitingPhase 3
Ages 2 to 17 · All sexes · Updated Nov 3, 2026 · NCT05923073

A Study of Guselkumab Versus Risankizumab in Participants With Moderately to Severely Active Crohn's Disease

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT07499232

A Study to Assess the Long-Term Safety of Ustekinumab Versus Other Biologics in Patients With Crohn's Disease and Ulcerative Colitis

RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT04372108

A Study to Investigate Efficacy and Safety of Brivekimig in Participants With Crohn's Disease

RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Nov 2, 2026 · NCT06958536

A Study of Vedolizumab in Adults With Ulcerative Colitis (UC) or Crohn's Disease (CD) in the Community Setting

RecruitingPhase 4
Ages 18 to 80 · All sexes · Updated Oct 28, 2026 · NCT06581328

Open-label Single-arm Study to Assess the Efficacy of Mirikizumab in Patients With Inflammatory Strictures Due to CD

RecruitingPhase 4
Ages 18 and older · All sexes · Updated Oct 26, 2026 · NCT06997965

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.