Investigating the Impact of Treadmill-integrated Virtual Reality Training on Walking Outside the Clinic

Inclusion Criteria:

* Have a clinically confirmed diagnosis of multiple sclerosis (MS).
* Be 18 years of age or older.
* Demonstrate ≥10% variability in stride length, step length, or gait asymmetry.
* Can ambulate without an assistive device, with a unilateral, or with a bilateral assistive device.
* Demonstrate no more than mild cognitive impairment, indicated by the Mini-Mental State Exam (score \>19).
* Possess adequate cognitive function to understand and follow research instructions.
* Be able to safely participate in the study and training procedures as determined by study staff.
* Be fluent in English and able to communicate discomfort, fatigue, or pain in English.
* Be able to travel to Shepherd Center to complete key assessment points in-person and for in-person training sessions twice per week.

Exclusion Criteria:

* Have a diagnosis of any other neurological condition or recent orthopedic conditions that affects gait, balance, or mobility.
* Exhibit \<10% variability in stride length, step length, or gait asymmetry.
* Are unable to ambulate (i.e. wheelchair bound or bedbound individuals).
* Have legal blindness or severe visual impairment that would interfere with virtual reality engagement or safe ambulation.
* Have a body weight exceeding 300 lbs., which exceeds the safety limits of the treadmill and body weight support system.
* Have uncontrolled or untreated hypertension, hypotension, or angina.
* Have a past or current history of epilepsy or any other type of seizure disorder, whether controlled or uncontrolled.
* Have undergone major surgery within the past 6 months or hospitalization within the past 3 months.