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Seizures clinical trials recruiting in the U.S.

56 studies for Seizures are recruiting participants at sites across the United States.

Seizures are caused by sudden, abnormal electrical activity in the brain. They can be mild or severe. Learn about the types, causes, and treatments.

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Recently updated studies

An Efficacy and Safety Study of Clemizole HCl in Patients With Lennox-Gastaut Syndrome

RecruitingPhase 3
Ages 2 to 55 ยท All sexes ยท Updated Oct 2, 2026 ยท NCT05066217

Natural History of Treated Neurocysticercosis and Long-Term Outcomes

RecruitingObservational studyHealthy volunteers welcome
Ages 3 to 99 ยท All sexes ยท Updated Oct 2, 2026 ยท NCT00001205

Investigating Epilepsy: Screening and Evaluation

RecruitingObservational study
Ages 8 to 110 ยท All sexes ยท Updated Oct 2, 2026 ยท NCT03478852

Tumor Related Epilepsy

RecruitingObservational study
Ages 8 to 99 ยท All sexes ยท Updated Oct 2, 2026 ยท NCT02639325

RENAISSANCE 2: SPN-817 Phase 2, Double-Blind, Placebo-Controlled Study in Adults With Focal Onset Seizures

RecruitingPhase 2
Ages 18 to 70 ยท All sexes ยท Updated Oct 1, 2026 ยท NCT06798896

Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures FOCUS-1

RecruitingPhase 3
Ages 18 to 75 ยท All sexes ยท Updated Oct 1, 2026 ยท NCT07563881

Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy

RecruitingPhase 1
Ages 18 to 60 ยท All sexes ยท Updated Sep 28, 2026 ยท NCT02531880

Optimizing Therapy in Epilepsy Using Seizure Forecasts Via EEG and Wearables

RecruitingEarly phase 1Mentions payment for participants
Ages 18 to 75 ยท All sexes ยท Updated Sep 25, 2026 ยท NCT07012148

Modulating Movement Intention Via Cortical Stimulation

RecruitingHealthy volunteers welcome
Ages 18 to 65 ยท All sexes ยท Updated Sep 25, 2026 ยท NCT03233399

Acute Effects of Focused Ultrasound Modulation on EEG Behavior in Status Epilepticus Patients

Recruiting
Ages 19 to 85 ยท All sexes ยท Updated Sep 21, 2026 ยท NCT05784805

Ketogenic Therapy Effects on Electrical and Metabolic Abnormalities in Epilepsy

Recruiting
Up to age 50 ยท All sexes ยท Updated Sep 17, 2026 ยท NCT02216500

Prospective Natural History Study of POLG Disease

RecruitingObservational study
All ages ยท All sexes ยท Updated Sep 15, 2026 ยท NCT07775872

A Study of EPX-100 (Clemizole Hydrochloride) in Participants With Dravet Syndrome

RecruitingPhase 3
Ages 2 and older ยท All sexes ยท Updated Sep 15, 2026 ยท NCT04462770

A Safety, Tolerability, and Preliminary Efficacy of Low-intensity Focused Ultrasound Neuromodulation in Patients With Drug-resistant Epilepsy

RecruitingPhase 1/2
Ages 18 and older ยท All sexes ยท Updated Sep 15, 2026 ยท NCT06388707

SeizEAR Safety Study

RecruitingHealthy volunteers welcome
Ages 18 to 70 ยท All sexes ยท Updated Sep 14, 2026 ยท NCT07088835

Prophylactic Anti-Seizure Medication vs No Anti-Seizure Medication for Patients With Primary Motor Cortex Brain Metastases

RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 8, 2026 ยท NCT07130786

Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures

RecruitingPhase 3
Ages 18 to 75 ยท All sexes ยท Updated Sep 2, 2026 ยท NCT07594119

Retraining and Control Therapy (ReACT): Sense of Control and Symptom Expectations as Targets of a Treatment for PNES

RecruitingHealthy volunteers welcome
Ages 11 to 18 ยท All sexes ยท Updated Aug 26, 2026 ยท NCT05096273

Comparative Effectiveness of Palliative Surgery Versus Additional Anti-Seizure Medications for Lennox-Gastaut Syndrome

RecruitingObservational study
Up to age 26 ยท All sexes ยท Updated Aug 6, 2026 ยท NCT05374824

Outcomes After Planned Discontinuation of AntiSeizure Medication

RecruitingPhase 4
Ages 18 and older ยท All sexes ยท Updated Aug 6, 2026 ยท NCT07750496

A Clinical Trial of Elsunersen in Pediatric SCN2A-DEE to Assess Efficacy and Safety

RecruitingPhase 3
1 Day โ€“ 18 Years ยท All sexes ยท Updated Aug 3, 2026 ยท NCT07019922

PeRampanel fOr Status ePilEpticus pRophylaxis Post-cardiac Arrest

RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Jul 29, 2026 ยท NCT06401707

buRst-supprESsion TO Stop Refractory Status Epilepticus Post-cardiac Arrest

RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Jul 29, 2026 ยท NCT05851391

Mapping of Human Cognition

Recruiting
Ages 18 to 75 ยท All sexes ยท Updated Jul 14, 2026 ยท NCT05989893

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.