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Seizures clinical trials recruiting in the U.S.
56 studies for Seizures are recruiting participants at sites across the United States.
Seizures are caused by sudden, abnormal electrical activity in the brain. They can be mild or severe. Learn about the types, causes, and treatments.
Cities with the most studies
- Washington, DC13 studies
- New York City, NY12 studies
- Philadelphia, PA11 studies
- Houston, TX8 studies
- Boston, MA8 studies
- Birmingham, AL7 studies
- Miami, FL6 studies
- Dallas, TX6 studies
- Durham, NC6 studies
- Chicago, IL6 studies
- Cincinnati, OH6 studies
- Cleveland, OH5 studies
- Charlotte, NC5 studies
- Phoenix, AZ5 studies
- Los Angeles, CA5 studies
- Clifton, NJ5 studies
- Orange, CA5 studies
- Orlando, FL5 studies
- Aurora, CO5 studies
- San Francisco, CA5 studies
- Portland, OR5 studies
- Little Rock, AR4 studies
- New Haven, CT4 studies
- Detroit, MI4 studies
- Nashville, TN4 studies
- San Diego, CA4 studies
- Salt Lake City, UT4 studies
- Seattle, WA4 studies
- Columbus, OH4 studies
- Louisville, KY3 studies
- East Pensacola Heights, FL3 studies
- Tucson, AZ3 studies
- Edison, NJ3 studies
- Mountain View, CA3 studies
- Jacksonville, FL3 studies
- Rochester, MN3 studies
- Austin, TX3 studies
- Milwaukee, WI3 studies
- Atlanta, GA3 studies
- Boise, ID3 studies
By state
- Alabama8 studies
- Arizona7 studies
- Arkansas5 studies
- California16 studies
- Colorado6 studies
- Connecticut4 studies
- Florida16 studies
- Georgia3 studies
- Idaho3 studies
- Illinois8 studies
- Kentucky4 studies
- Maryland11 studies
- Massachusetts9 studies
- Michigan7 studies
- Minnesota4 studies
- Missouri4 studies
- New Jersey8 studies
- New York16 studies
- North Carolina11 studies
- Ohio13 studies
- Oregon5 studies
- Pennsylvania12 studies
- Tennessee6 studies
- Texas14 studies
- Utah5 studies
- Virginia3 studies
- Washington4 studies
- Wisconsin4 studies
Recently updated studies
An Efficacy and Safety Study of Clemizole HCl in Patients With Lennox-Gastaut Syndrome
RecruitingPhase 3
Ages 2 to 55 ยท All sexes ยท Updated Oct 2, 2026 ยท NCT05066217Natural History of Treated Neurocysticercosis and Long-Term Outcomes
RecruitingObservational studyHealthy volunteers welcome
Ages 3 to 99 ยท All sexes ยท Updated Oct 2, 2026 ยท NCT00001205A Study to Evaluate the Efficacy and Safety of Cannabidiol Oral Solution (CBD-OS [GWP42003-P, JZP926]) for the Treatment of Focal-Onset Seizures
RecruitingPhase 1
Ages 12 to 75 ยท All sexes ยท Updated Oct 2, 2026 ยท NCT07233239Investigating Epilepsy: Screening and Evaluation
RecruitingObservational study
Ages 8 to 110 ยท All sexes ยท Updated Oct 2, 2026 ยท NCT03478852Tumor Related Epilepsy
RecruitingObservational study
Ages 8 to 99 ยท All sexes ยท Updated Oct 2, 2026 ยท NCT02639325RENAISSANCE 2: SPN-817 Phase 2, Double-Blind, Placebo-Controlled Study in Adults With Focal Onset Seizures
RecruitingPhase 2
Ages 18 to 70 ยท All sexes ยท Updated Oct 1, 2026 ยท NCT06798896Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures FOCUS-1
RecruitingPhase 3
Ages 18 to 75 ยท All sexes ยท Updated Oct 1, 2026 ยท NCT07563881Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy
RecruitingPhase 1
Ages 18 to 60 ยท All sexes ยท Updated Sep 28, 2026 ยท NCT02531880Optimizing Therapy in Epilepsy Using Seizure Forecasts Via EEG and Wearables
RecruitingEarly phase 1Mentions payment for participants
Ages 18 to 75 ยท All sexes ยท Updated Sep 25, 2026 ยท NCT07012148Modulating Movement Intention Via Cortical Stimulation
RecruitingHealthy volunteers welcome
Ages 18 to 65 ยท All sexes ยท Updated Sep 25, 2026 ยท NCT03233399Acute Effects of Focused Ultrasound Modulation on EEG Behavior in Status Epilepticus Patients
Recruiting
Ages 19 to 85 ยท All sexes ยท Updated Sep 21, 2026 ยท NCT05784805Ketogenic Therapy Effects on Electrical and Metabolic Abnormalities in Epilepsy
Recruiting
Up to age 50 ยท All sexes ยท Updated Sep 17, 2026 ยท NCT02216500Prospective Natural History Study of POLG Disease
RecruitingObservational study
All ages ยท All sexes ยท Updated Sep 15, 2026 ยท NCT07775872A Study of EPX-100 (Clemizole Hydrochloride) in Participants With Dravet Syndrome
RecruitingPhase 3
Ages 2 and older ยท All sexes ยท Updated Sep 15, 2026 ยท NCT04462770A Safety, Tolerability, and Preliminary Efficacy of Low-intensity Focused Ultrasound Neuromodulation in Patients With Drug-resistant Epilepsy
RecruitingPhase 1/2
Ages 18 and older ยท All sexes ยท Updated Sep 15, 2026 ยท NCT06388707SeizEAR Safety Study
RecruitingHealthy volunteers welcome
Ages 18 to 70 ยท All sexes ยท Updated Sep 14, 2026 ยท NCT07088835Prophylactic Anti-Seizure Medication vs No Anti-Seizure Medication for Patients With Primary Motor Cortex Brain Metastases
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 8, 2026 ยท NCT07130786Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures
RecruitingPhase 3
Ages 18 to 75 ยท All sexes ยท Updated Sep 2, 2026 ยท NCT07594119Retraining and Control Therapy (ReACT): Sense of Control and Symptom Expectations as Targets of a Treatment for PNES
RecruitingHealthy volunteers welcome
Ages 11 to 18 ยท All sexes ยท Updated Aug 26, 2026 ยท NCT05096273Comparative Effectiveness of Palliative Surgery Versus Additional Anti-Seizure Medications for Lennox-Gastaut Syndrome
RecruitingObservational study
Up to age 26 ยท All sexes ยท Updated Aug 6, 2026 ยท NCT05374824Outcomes After Planned Discontinuation of AntiSeizure Medication
RecruitingPhase 4
Ages 18 and older ยท All sexes ยท Updated Aug 6, 2026 ยท NCT07750496A Clinical Trial of Elsunersen in Pediatric SCN2A-DEE to Assess Efficacy and Safety
RecruitingPhase 3
1 Day โ 18 Years ยท All sexes ยท Updated Aug 3, 2026 ยท NCT07019922PeRampanel fOr Status ePilEpticus pRophylaxis Post-cardiac Arrest
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Jul 29, 2026 ยท NCT06401707buRst-supprESsion TO Stop Refractory Status Epilepticus Post-cardiac Arrest
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Jul 29, 2026 ยท NCT05851391Mapping of Human Cognition
Recruiting
Ages 18 to 75 ยท All sexes ยท Updated Jul 14, 2026 ยท NCT05989893From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.