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Healthy volunteer studies in Sioux Falls, SD

12 studies at sites in and around Sioux Falls accept healthy volunteers — people without the condition being studied. Many studies pay participants for their time and travel; the amount is set by each study, so ask the study team.

Education & Mentorship of Advanced Practice Providers to Increase Community-based Research Within the NCORP Network, COACH-APP Trial

RecruitingHealthy volunteers welcome
  • Sanford Cancer Center Oncology Clinic, Sioux Falls
Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT06904391

Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays

RecruitingHealthy volunteers welcome
  • Sanford Cancer Center Oncology Clinic, Sioux Falls
  • Sanford USD Medical Center - Sioux Falls, Sioux Falls
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT07283939

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • Sanford Cancer Center Oncology Clinic, Sioux Falls
  • Sanford USD Medical Center - Sioux Falls, Sioux Falls
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069

Observational Study of Decentralized Urine Optical Interaction Patterns Associated With Environmental Microplastic and Nanoplastic Exposure

RecruitingObservational studyHealthy volunteers welcome
  • Decentralized / At-Home Participation (U.S.), Sioux Falls
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT07775495

Connect for Cancer Prevention Study (Connect)

RecruitingObservational studyHealthy volunteers welcome
  • Sanford Health, Sioux Falls
Ages 30 to 70 · All sexes · Updated Sep 17, 2026 · NCT04609072

BL-RX01-TFSTAB-1402

RecruitingPhase 4Healthy volunteers welcome
  • Vance Thompson Vision, Sioux Falls
Ages 18 and older · All sexes · Updated Aug 27, 2026 · NCT07790211

Efficacy of Kera Sol Tears on Signs and Symptoms of Surgical Temporary Ocular Discomfort Syndrome (STODS) in Subjects Following LASIK

RecruitingPhase 4Healthy volunteers welcome
  • Vance Thompson Vision Clinic, Prof. LLC, Sioux Falls
Ages 18 and older · All sexes · Updated Jul 13, 2026 · NCT07155070

Helix Research Network

RecruitingObservational studyHealthy volunteers welcome
  • Sanford Health (Imagine You), Sioux Falls
Ages 18 and older · All sexes · Updated Mar 23, 2026 · NCT06057181

Midwest Birth Outcomes and Indigenous American Pregnancy

RecruitingObservational studyHealthy volunteers welcome
  • Sanford Health, Sioux Falls
Ages 18 and older · Women · Updated Mar 20, 2026 · NCT06008561

General Population Level Estimation for Type 1 Diabetes Risk in Children During Routine Care Delivery

RecruitingObservational studyHealthy volunteers welcome
  • Sanford Sioux Falls Region Clinics, Sioux Falls
0 Minutes – 17 Years · All sexes · Updated Mar 2, 2026 · NCT04477928

Evaluating Crosslinked Hyaluronate Canalicular Gel for the Treatment of DED in Patients Undergoing Cataract Surgery

RecruitingHealthy volunteers welcome
  • Vance Thompson Vision Clinic, Prof. LLC, Sioux Falls
Ages 22 and older · All sexes · Updated Sep 29, 2025 · NCT07155057

Improving Neurodevelopmental ouTcomes After Prenatal Cannabinoid in uTero Exposure

RecruitingHealthy volunteers welcome
  • Avera Research Institute, Sioux Falls
7 Days · All sexes · Updated Jun 24, 2025 · NCT06423664

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.