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Post-COVID Conditions (Long COVID) clinical trials in California

30 studies for Post-COVID Conditions (Long COVID) are looking for participants at sites in California.

Cities in California

A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023)

  • Clinica de Salud del Valle de Salinas ( Site 3825), Castroville
  • Pacific Clinical Studies ( Site 3827), Los Alamitos
  • Valley Clinical Trials, Inc. ( Site 3707), Northridge
  • and 4 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT06667700

Exercise in Child Health

  • University of California, Irvine, Irvine
RecruitingHealthy volunteers welcome
Ages 10 to 17 · All sexes · Updated Oct 2, 2026 · NCT05359991

Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen

  • Research Site, Fresno
  • Research Site, Newport Beach
  • Research Site, Torrance
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT05624450

A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised

  • Hope Clinical Research, Inc., Canoga Park
  • Amicis Research Center - Granada Hills, Granada Hills
  • Jacobs Medical Center at UC San Diego Health, La Jolla
  • and 4 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07013474

Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID

  • University of California, Los Angeles (UCLA), Los Angeles
  • University of California San Francisco, San Francisco
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06631287

A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe Disease

  • National Institute of Clinical Research - Bakersfield, Bakersfield
  • Velocity Clinical Research, Huntington Park, Huntington Park
  • 310 Clinical Research, Inglewood
  • and 9 more
RecruitingPhase 3
Ages 12 and older · All sexes · Updated Sep 25, 2026 · NCT06679140

A Study to Examine Anktiva for the Treatment of COVID-19.

  • Chan Soon-Schiong Institute for Medicine (CSSIFM), El Segundo
RecruitingPhase 2
Ages 18 to 70 · All sexes · Updated Sep 24, 2026 · NCT07123727

Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

  • Lucile Packard Children's Hospital, Palo Alto
RecruitingObservational studyHealthy volunteers welcome
Ages 0 to 20 · All sexes · Updated Aug 21, 2026 · NCT04278404

Validation of Biomarkers for Long COVID in the LIINC Viral Immunopathogenesis and Persistence Repeat Donor Cohort (VIPER)

  • Zuckerberg San Francisco General Hospital, San Francisco
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07770022

A Phase 1/2A, Randomized Study of a T Follicular Helper (TFH)-Targeting Genetic Vaccine Strategy Designed to Induce Broad, Durable Immune Responses

  • UCLA Westwood, Los Angeles
  • UCSF Community and Clinical Research Center, San Francisco
RecruitingPhase 1/2Healthy volunteers welcome
Ages 40 to 64 · All sexes · Updated Aug 18, 2026 · NCT06810934

A Study to Learn About a COVID-19 Vaccine in Healthy Adults 18 Through 64 Years of Age

  • Diablo Clinical Research, LLC dba Flourish Research, Walnut Creek
RecruitingPhase 4Healthy volunteers welcome
Ages 18 to 64 · All sexes · Updated Aug 7, 2026 · NCT07730450

Long-term Impact of Infection With Novel Coronavirus (COVID-19)

  • Zuckerberg San Francisco General Hospital (ZSFG), San Francisco
RecruitingObservational study
Ages 18 to 100 · All sexes · Updated Jul 23, 2026 · NCT04362150

A Study on the Safety and Immune Response of Investigational mRNA Seasonal Flu/COVID-19 Combination Vaccine in Adults

  • GSK Investigational Site, Fair Oaks
  • GSK Investigational Site, San Diego
RecruitingPhase 1
Ages 65 to 85 · All sexes · Updated Jun 30, 2026 · NCT07464314

Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study

  • City of Hope cancer Center, Duarte
  • University of California Davis Health System, Sacramento
RecruitingPhase 3
All ages · All sexes · Updated Jun 23, 2026 · NCT03808922

Water-based Activity to Enhance Recovery in Long COVID-19

  • VA Palo Alto Health Care System, Palo Alto, CA, Palo Alto
Recruiting
Ages 18 to 89 · All sexes · Updated Jun 18, 2026 · NCT06142253

Multiparametric [18F]F-AraG Imaging in Post-Acute Sequelae of COVID-19 (PASC)

  • UC Davis EXPLORER Molecular Imaging Center, Sacramento
  • University of California San Francisco, San Francisco
RecruitingEarly phase 1Healthy volunteers welcome
Ages 18 and older · All sexes · Updated May 22, 2026 · NCT07076862

A Study to Assess Anktiva in Patients With Long Covid-19.

  • University of California - San Francisco, San Francisco
RecruitingPhase 2
Ages 18 to 70 · All sexes · Updated May 11, 2026 · NCT07108036

Imaging Immune Activation in COVID-19

  • University of California, San Francisco, San Francisco
RecruitingPhase 2
Ages 18 and older · All sexes · Updated May 8, 2026 · NCT04815096

Impact of the Coronavirus (COVID-19) on Patients With Cancer

  • Stanford University School of Medicine, Stanford
RecruitingObservational study
Ages 18 to 99 · All sexes · Updated Apr 27, 2026 · NCT04330521

Long Covid (LC)-REVITALIZE - A Long Covid Repurposed Drug Study

  • Laura Rodriguez Research Institute, San Diego
RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Apr 3, 2026 · NCT06928272

Percutaneous Electrical Nerve Field Stimulation (PENFS) in Patients With Post Concussion Syndrome (PCS)

  • CHOC Children's, Orange
Recruiting
Ages 11 to 18 · All sexes · Updated Mar 18, 2026 · NCT04978571

Acupuncture and Chinese Herbal Medicine for Long COVID

  • SCUHS, Whittier
Recruiting
Ages 18 and older · All sexes · Updated Dec 16, 2025 · NCT07285707

Preparedness Through Respiratory Virus Epidemiology and Community Engagement

  • UC San Diego, La Jolla
  • San Ysidro Health, San Ysidro
RecruitingObservational studyHealthy volunteers welcome
All ages · All sexes · Updated Nov 4, 2025 · NCT07147517

COVID-19 International Drug Pregnancy Registry

  • Pregistry, Los Angeles
RecruitingObservational study
Ages 18 to 50 · Women · Updated Sep 26, 2025 · NCT05013632

Impact of Aerosol Box Use During Cardiopulmonary Arrest: A Multicenter Study

  • Department of Emergency Medicine, Children's Hospital of Los Angeles, Los Angeles
RecruitingHealthy volunteers welcome
Ages 18 to 60 · All sexes · Updated Sep 5, 2025 · NCT05868239

EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease

  • UCLA David Geffen School of Medicine, Los Angeles
  • UCLA, Los Angeles
RecruitingPhase 3
Ages 0 to 17 · All sexes · Updated Jul 17, 2025 · NCT05261139

The Long COVID-19 Wearable Device Study

  • Scripps Research, La Jolla
Recruiting
Ages 18 and older · All sexes · Updated May 11, 2025 · NCT05741112

Researchers At UC San Diego Are Learning About the Benefits of Human Milk and How It Influences Infant and Child Health

  • University of California, San Diego, San Diego
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · Women · Updated Jan 31, 2025 · NCT05553743

Obesity, Insulin Resistance, and PASC: Persistent SARS-CoV-2

  • Stanford Health, Palo Alto
RecruitingHealthy volunteers welcome
Ages 18 to 80 · All sexes · Updated Dec 4, 2024 · NCT05833217

Mesenchymal Stem Cells for the Treatment of Various Chronic and Acute Conditions

  • Southern California Hospital at Culver City / Southern California Hospital at Hollywood / Multiple US-based Sub-Investigator Sites, Culver City
RecruitingPhase 1/2Healthy volunteers welcome
Ages 18 and older · All sexes · Updated Apr 29, 2022 · NCT04684602

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.