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Post-COVID Conditions (Long COVID) clinical trials recruiting in the U.S.
118 studies for Post-COVID Conditions (Long COVID) are recruiting participants at sites across the United States.
Anyone who had COVID-19 can have ongoing symptoms. Learn about post-COVID conditions (long COVID), including symptoms, diagnosis, treatments, and prevention.
Cities with the most studies
- New York City, NY15 studies
- Houston, TX13 studies
- Boston, MA13 studies
- Baltimore, MD12 studies
- Chicago, IL11 studies
- Washington, DC10 studies
- Durham, NC8 studies
- San Francisco, CA8 studies
- Atlanta, GA8 studies
- San Diego, CA7 studies
- Los Angeles, CA6 studies
- Salt Lake City, UT6 studies
- Hialeah, FL6 studies
- Miami, FL6 studies
- Dallas, TX5 studies
- Pittsburgh, PA5 studies
- Columbus, OH5 studies
- Seattle, WA4 studies
- Cincinnati, OH4 studies
- Mountain View, CA4 studies
- San Antonio, TX4 studies
- Nashville, TN4 studies
- Tampa, FL4 studies
- St. Louis, MO4 studies
- Birmingham, AL4 studies
- Louisville, KY4 studies
- Overland Park, KS3 studies
- Cedar Rapids, IA3 studies
- Sacramento, CA3 studies
- Austin, TX3 studies
- Detroit, MI3 studies
- Baton Rouge, LA3 studies
- Boise, ID3 studies
- Warren, MI3 studies
- Kendall, FL3 studies
- Charleston, SC3 studies
- St. Petersburg, FL3 studies
- Omaha, NE3 studies
- Homestead, FL3 studies
- The Woodlands, TX3 studies
By state
- Alabama7 studies
- Arizona4 studies
- California30 studies
- Colorado6 studies
- Connecticut3 studies
- District of Columbia4 studies
- Florida13 studies
- Georgia11 studies
- Idaho3 studies
- Illinois13 studies
- Iowa3 studies
- Kansas3 studies
- Kentucky6 studies
- Louisiana7 studies
- Maryland21 studies
- Massachusetts13 studies
- Michigan6 studies
- Minnesota6 studies
- Missouri4 studies
- Nebraska3 studies
- Nevada4 studies
- New Jersey3 studies
- New York18 studies
- North Carolina10 studies
- Ohio11 studies
- Oregon3 studies
- Pennsylvania10 studies
- South Carolina4 studies
- Tennessee8 studies
- Texas23 studies
- Utah7 studies
- Virginia6 studies
- Washington5 studies
Recently updated studies
Clinical Outcomes and Pharmacotherapy Effectiveness in the VA Health Care System (COPE-VA)
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT06160128SARS-CoV-2 Specific Monoclonal Antibody for Post-COVID-19 Conditions (Long COVID)
RecruitingPhase 2
Ages 18 to 70 · All sexes · Updated Sep 29, 2026 · NCT07021794Heat thErapy And mobiLity in COVID-19 Survivors
Recruiting
Ages 50 to 90 · All sexes · Updated Sep 28, 2026 · NCT06928116Long-Term Study of COVID-19 Infection and Long COVID
RecruitingObservational study
Ages 18 to 75 · All sexes · Updated Sep 28, 2026 · NCT07781501A Study of COVID-19 Vaccine(s) in Children and Adults
RecruitingPhase 3Healthy volunteers welcome
Ages 5 and older · All sexes · Updated Sep 28, 2026 · NCT07798648A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe Disease
RecruitingPhase 3
Ages 12 and older · All sexes · Updated Sep 25, 2026 · NCT06679140Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06631287A Safety and Immunogenicity Trial of OCU500, ChAd36 Vector Encoding SARS-CoV-2 Spike Vaccine Via Intranasal and Inhalational Routes in Previously Vaccinated Adults
RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 64 · All sexes · Updated Sep 25, 2026 · NCT07536308A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07013474A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023)
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06667700A Study to Examine Anktiva for the Treatment of COVID-19.
RecruitingPhase 2
Ages 18 to 70 · All sexes · Updated Sep 24, 2026 · NCT07123727A Study of Secutrelvir in Participants With Coronavirus Disease 2019 (COVID-19) Who Are at High Risk for Progression to Severe Disease
RecruitingPhase 3
Ages 12 and older · All sexes · Updated Sep 21, 2026 · NCT07743580Piloting Virtual Reality Environments to Treat PTSD in Healthcare Workers
RecruitingEarly phase 1
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT04887116Cross-Sectional Evaluation of Persistence of SARS-CoV-2 Remnants After Recovery From Acute Infection
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 110 · All sexes · Updated Sep 16, 2026 · NCT06577467Viral Infections in Healthy and Immunocompromised Hosts
RecruitingObservational studyHealthy volunteers welcome
6 Months – 120 Years · All sexes · Updated Sep 14, 2026 · NCT01306084A Study Evaluating MDX2301 in Healthy Adults and Adults at Higher Risk for Severe COVID-19.
RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 64 · All sexes · Updated Sep 10, 2026 · NCT07445971Send-In Sample Collection for Comprehensive Analyses of Innate and Adaptive Immune Responses During Acute COVID-19 and Convalescence
RecruitingObservational studyHealthy volunteers welcome
1 Day – 99 Years · All sexes · Updated Sep 9, 2026 · NCT04582903Natural History of Post-Coronavirus Disease 19 Convalescence at the National Institutes of Health
RecruitingObservational study
Ages 18 to 100 · All sexes · Updated Sep 9, 2026 · NCT04573062Long-Covid-19 Alleviation Through Learning Mindfulness Study
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Aug 31, 2026 · NCT07140094Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Aug 28, 2026 · NCT05624450Dime La VerDAD: Verify, Debunk, and Disseminate
RecruitingHealthy volunteers welcome
Ages 18 to 99 · All sexes · Updated Aug 26, 2026 · NCT06417762Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
RecruitingObservational studyHealthy volunteers welcome
Ages 0 to 20 · All sexes · Updated Aug 21, 2026 · NCT04278404PET Imaging of Cyclooxygenase-1 in Participants With Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)
RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 70 · All sexes · Updated Aug 18, 2026 · NCT06920628Validation of Biomarkers for Long COVID in the LIINC Viral Immunopathogenesis and Persistence Repeat Donor Cohort (VIPER)
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07770022A Phase 1/2A, Randomized Study of a T Follicular Helper (TFH)-Targeting Genetic Vaccine Strategy Designed to Induce Broad, Durable Immune Responses
RecruitingPhase 1/2Healthy volunteers welcome
Ages 40 to 64 · All sexes · Updated Aug 18, 2026 · NCT06810934From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.