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Brain and Spinal Cord Tumors clinical trials recruiting in the U.S.

43 studies for Brain and Spinal Cord Tumors are recruiting participants at sites across the United States.

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Recently updated studies

Somatic Mosaicism in Twins Discordant for Childhood Cancer

RecruitingObservational study
Up to age 18 · All sexes · Updated Oct 1, 2026 · NCT06054295

Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma

RecruitingPhase 1/2
Ages 18 to 99 · All sexes · Updated Sep 28, 2026 · NCT07416188

Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06047379

Trial of Anti-PD-1 Immunotherapy and Stereotactic Radiation in Patients With Recurrent Glioblastoma

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT04977375

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RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT07827001

A Study of the Safety, Dosing, and Delivery of NEO100 in Patients With Pediatric Brain Tumors

RecruitingPhase 1
Ages 5 to 18 · All sexes · Updated Sep 15, 2026 · NCT06357377

Patient Perceptions Around Quality of Care Through Telemedicine in Neuro-Oncology

RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT04988009

Gadolinium and Ferumoxytol MRI in Diagnosing Patients With Abnormalities in the Central Nervous System

RecruitingPhase 2
Ages 10 and older · All sexes · Updated Sep 14, 2026 · NCT03270059

Multiple Dose Intraventricular Administration of Rhenium-186 NanoLiposome for Leptomeningeal Metastases

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT07098806

Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT05386108

HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

RecruitingPhase 1
36 Months – 22 Years · All sexes · Updated Sep 4, 2026 · NCT03911388

Brain Slice Explants to Predict Drug Response in Brain Tumors

RecruitingObservational study
All ages · All sexes · Updated Sep 4, 2026 · NCT05978557

A Study of Mirdametinib in People With Central Nervous System Tumors

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT07539441

B7-H3.CD28Z.CART in CNS Neoplasms

RecruitingPhase 1
Ages 2 to 21 · All sexes · Updated Sep 3, 2026 · NCT07390539

Project: Every Child for Younger Patients With Cancer

RecruitingObservational study
Up to age 25 · All sexes · Updated Aug 25, 2026 · NCT02402244

A Study of PHST001 in Advanced Solid Tumors

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Aug 12, 2026 · NCT06840886

ASTX727 in Recurrent/Progressive Non-enhancing IDH Mutant Gliomas

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT03922555

Next Generation Sequencing of Normal Tissues Prospectively in Pediatric Oncology Patients

RecruitingObservational study
All ages · All sexes · Updated Jul 22, 2026 · NCT02530658

Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors

RecruitingPhase 1/2
Ages 4 to 39 · All sexes · Updated Jul 20, 2026 · NCT05278208

DALY II USA/ MB-CART2019.1 for DLBCL

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jul 13, 2026 · NCT04792489

Integrated Cancer Repository for Cancer Research

RecruitingObservational studyHealthy volunteers welcome
Ages 19 to 110 · All sexes · Updated Jun 29, 2026 · NCT02012699

Data Collection for the Assessment of Acute and Late Normal Tissue in Patients Treated With Proton Therapy

RecruitingObservational study
Ages 18 and older · All sexes · Updated Jun 12, 2026 · NCT00991094

ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors

RecruitingPhase 1
Ages 2 to 21 · All sexes · Updated Jun 11, 2026 · NCT04732065

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.