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Major Depressive Disorder clinical trials in Oklahoma

12 studies for Major Depressive Disorder are looking for participants at sites in Oklahoma.

Cities in Oklahoma

A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder

  • Conrad Clinical Research, Edmond
  • Sooner Clinical Research, Oklahoma City
RecruitingPhase 3
Ages 18 to 74 · All sexes · Updated Oct 1, 2026 · NCT07573176

Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms

  • Conrad Clinical Research, Edmond
RecruitingPhase 3
Ages 18 to 74 · All sexes · Updated Sep 25, 2026 · NCT06559306

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)

  • Sooner Clinical Research, Oklahoma City
RecruitingPhase 3
Ages 18 to 74 · All sexes · Updated Sep 8, 2026 · NCT07076407

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder

  • Pahl Pharmaceutical Professionals Llc, Oklahoma City
RecruitingPhase 3
Ages 18 to 74 · All sexes · Updated Aug 3, 2026 · NCT06775379

A Study to Evaluate the Maintenance Effect of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

  • Neurocrine Clinical Site, Edmond
  • Neurocrine Clinical Site, Oklahoma City
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT07196501

Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

  • Neurocrine Clinical Site, Edmond
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT06966401

Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol

  • Clinical Research Site, Edmond
  • Clinical Research Site, Oklahoma City
RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Jul 24, 2026 · NCT07484217

A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder

  • Sooner Clinical Research /ID# 277659, Oklahoma City
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Jun 15, 2026 · NCT07276997

Neural Response to Inflammatory Challenge in Major Depressive Disorder

  • Laureate Institute for Brain Research, Tulsa
RecruitingPhase 1/2Healthy volunteers welcome
Ages 18 to 65 · All sexes · Updated Apr 21, 2026 · NCT04751331

Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)

  • Autobahn Site #107, Oklahoma City
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Jan 20, 2026 · NCT06633016

Study of ALTO-300 in MDD

  • Site 195, Oklahoma City
RecruitingPhase 2
Ages 18 to 70 · All sexes · Updated Jul 24, 2025 · NCT05922878

A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms

  • Clinical Research Site, Edmond
  • Clinical Research Site, Oklahoma City
RecruitingPhase 4
Ages 18 to 65 · All sexes · Updated Jan 23, 2025 · NCT06223880

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.