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Metastatic Cancer clinical trials in Minnesota
40 studies for Metastatic Cancer are looking for participants at sites in Minnesota.
Cities in Minnesota
- Rochester31 studies
- Minneapolis10 studies
- Saint Paul7 studies
- Plymouth4 studies
- Bloomington3 studies
- Brooklyn Park3 studies
Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial
- Sanford Joe Lueken Cancer Center, Bemidji
- Mercy Hospital, Coon Rapids
- Essentia Health - Deer River Clinic, Deer River
- and 12 more
RecruitingPhase 2
All ages · All sexes · Updated Oct 2, 2026 · NCT05564377Adding Spatially Fractionated Radiation Therapy to Standard Palliative Radiation for Improving Disease-Related Symptoms in Patients With Unresectable Solid Tumors
- Mayo Clinic in Rochester, Rochester
Recruiting
Ages 15 and older · All sexes · Updated Oct 2, 2026 · NCT07856394A Study of HC-7366 in Combination With Belzutifan (WELIREG™) in Patients With Renal Cell Carcinoma
- HealthPartners Cancer Research Center, Saint Paul
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06234605SRS Compared With FSRS for Treatment of Intact Metastatic Brain Disease, FRACTIONATE Trial
- Mayo Clinic Health System in Albert Lea, Albert Lea
- Mayo Clinic Health Systems-Mankato, Mankato
- Mayo Clinic in Rochester, Rochester
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT05222620PRE-ISPY Phase I/II Oncology Platform Program
- University of Minnesota Masonic Cancer Center, Minneapolis
- Mayo Clinic Comprehensive Cancer Center, Rochester
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT05868226Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors
- Mayo Clinic, Rochester
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT06943755Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer
- Avera Cancer Institute- Marshall, Marshall
- Mayo Clinic Hospital, Methodist Campus, Research Pharmacy, Rochester
- Mayo Clinic Pharmacy, Rochester
- and 4 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07222800A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors
- Mayo Clinic Rochester, Rochester
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07277413Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
- Minnesota Oncology Hematology, P.A., Burnsville
- Minnesota Oncology Hematology, P.A., Chaska
- Allina Health Cancer Institute - Mercy Hospital, Coon Rapids
- and 7 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07222566A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue
- Mayo Clinic Cancer Center Outpatient Pharmacy, Rochester
- Mayo Clinic, Rochester
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06989437A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION-Breast05)
- Research Site, Saint Paul
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06103864ASPEN-09-03: A Study of Evorpacept in Combination With Trastuzumab and Chemotherapy in Metastatic HER2-Positive Breast Cancer
- Mayo Clinic Cancer Center, Rochester
- HealthPartners Frauenshuh Cancer Center, Saint Louis Park
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07007559A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)
- Allina Health Cancer Institute - Abbott Northwestern Hospital, Minneapolis
- Mayo Clinic in Rochester, Minnesota, Rochester
- Metro-Minnesota Community Clinical Oncology, Saint Louis Park
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07174336A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer
- Mayo Clinic in Rochester, Minnesota, Rochester
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07213804Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer
- Minnesota Oncology and Hematology PA, Minneapolis
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT05267626A Study of Nuzefatide Pevedotin (BT5528) in Patients With Metastatic Pancreatic Ductal Adenocarcinoma (PDAC)
- Mayo Clinic Rochester, Rochester
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT07450859Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer
- Minnesota Oncology Hematology, P.A., Burnsville
- Minnesota Oncology Hematology, P.A., Chaska
- Minnesota Oncology Hematology, P.A., Coon Rapids
- and 6 more
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07227415CREO - Microwave Ablation Feasibility Study
- Mayo Clinic Rochester, Rochester
Recruiting
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT07817147Testing the Combination of DS-8201a and Olaparib in HER2-Expressing Cancers With Expansion in Patients With Platinum Resistant Ovarian Cancer
- Mayo Clinic in Rochester, Rochester
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT04585958A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer
- Allina Health Cancer Institute - Abbott Northwestern Hospital, Minneapolis
- HealthPartners Cancer Research Center, Saint Paul
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT06119581A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors
- Mayo Clinic - Rochester, Rochester
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT04913285Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.
- Mayo Clinic-Comprehensive Cancer Center-Breast Clinic, Rochester
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT06072612A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer
- Research Site, Rochester
RecruitingPhase 2
Ages 18 to 130 · All sexes · Updated Aug 18, 2026 · NCT06792695FOG-001 in Locally Advanced or Metastatic Solid Tumors
- M Health Fairview University of Minnesota Medical Center, Minneapolis
- Mayo Clinic, Rochester
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT05919264A Study to Investigate Safety and Effectiveness of CRN09682 in Participants With SST2-Expressing NENs and Other Solid Tumors
- Crinetics Study Site, Rochester
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Jul 31, 2026 · NCT07129252A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors
- Minnesota Oncology Hematology, Maple Grove
- Mayo Clinic (Minnesota), Rochester
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Jul 30, 2026 · NCT04657068Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)
- Research Site, Minneapolis
RecruitingPhase 3
Ages 18 and older · Women · Updated Jul 29, 2026 · NCT07044336A Study of ASP1002 in Adults for Treatment of Solid Tumors
- HealthPartners Cancer Research Center, Saint Paul
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Jul 23, 2026 · NCT05719558A Clinical Study of KTX-2001 in Subjects With Metastatic Castration-Resistant Prostate Cancer (STRIKE-001)
- Mayo Clinic, Rochester
RecruitingPhase 1
Ages 18 and older · Men · Updated Jul 9, 2026 · NCT07103018Evaluation of Anti-PD-1 Therapy by Monitoring T Cell Responses in Melanoma, Lung and Other Cancer Types
- Mayo Clinic in Rochester, Rochester
RecruitingObservational study
Ages 18 and older · All sexes · Updated Jun 18, 2026 · NCT06075524Group Cognitive Behavior Sessions (CBCSM) to Decrease Distress in Cancer Patients
- Mayo Clinic in Rochester, Rochester
Recruiting
Ages 18 and older · All sexes · Updated Jun 9, 2026 · NCT06015932Examining Blood and Tissue Samples to Identify Diagnostic Markers in Patients With Metastatic Cancer Undergoing Tumor Removal
- Mayo Clinic in Rochester, Rochester
RecruitingObservational study
Ages 18 and older · All sexes · Updated Jun 9, 2026 · NCT05530759Placebo-Controlled Trial of IFx-Hu2.0 Followed By Pembrolizumab In Checkpoint Inhibitor Naïve Participants With Advanced Or Metastatic Merkel Cell Carcinoma
- Mayo Clinic Comprehensive Cancer Center, Rochester
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Apr 17, 2026 · NCT06947928A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma
- Mayo Clinic Rochester, Rochester
RecruitingPhase 2/3
All ages · All sexes · Updated Apr 2, 2026 · NCT06581406Immune Checkpoint Inhibitor Response in Solid Tumors Using a Live Tumor Diagnostic Platform
- Mayo Clinic in Rochester, Rochester
RecruitingObservational study
Ages 18 and older · All sexes · Updated Mar 12, 2026 · NCT06349642Ivosidenib in Participants With Locally Advanced or Metastatic Conventional Chondrosarcoma Untreated or Previously Treated With 1 Systemic Treatment Regimen
- Mayo Clinic - Rochester, Mn, Rochester
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Feb 6, 2026 · NCT06127407Study of PAT in Patients With Solid Tumor Cancers
- Masonic Cancer Center at University of Minnesota, Minneapolis
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Dec 9, 2025 · NCT05338658SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
- Massive Bio SYNERGY-AI site, Duluth
RecruitingObservational study
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774Highly Selective CDK7 Inhibitor Q901 in Selected Advanced Solid Tumors
- Mayo Clinic, Rochester
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Aug 17, 2025 · NCT05394103A Study to Evaluate the Safety and Therapeutic Activity of GI-102 As a Single Agent and in Combination with Conventional Anti-cancer Drugs, Pembrolizumab or Trastuzumab Deruxtecan(T-DXd) in Patients with Advanced Solid Tumors (KEYNOTE-G08)
- Mayo Clinic in Minnesota, Rochester
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 25, 2024 · NCT05824975From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.