CREO - Microwave Ablation Feasibility Study

Recruiting

Investigator-Initiated Feasibility Study of a Novel Endoscopic Ultrasound Guided Microwave Ablation Device in Patients With Locally Advanced, Unresectable, or Metastatic Cancer

Who can join

Ages 18 and older · All sexes

Full eligibility criteria

Inclusion Criteria:

* Male or female ≥18 years of age
* Willing and able to provide written informed consent
* Histologically confirmed locally advanced, unresectable or metastatic cancer (Stage III or IV)
* At least 1 tumor that is indicated for MWA, and the location of target tumor must be accessible via EUS through the gastric wall (eg, pancreas, liver, etc).
* The tumor(s) must be ≥1 cm in diameter

Exclusion Criteria:

* Participant is a candidate for upfront resection of pancreatic cancer
* Participation in another clinical trial that involves local ablation or any other local therapy that could affect the target organ or lesions treated in this study
* Any condition that, in the opinion of the investigator, may increase the risk to the participant's safety or well-being

About the study

The goal of this study is to assess the overall success of energy delivery during treatment using the ultrasound guided microwave ablation device in patients with locally advanced, unresectable, or metastatic cancer. Secondly, this study aims to explore the procedural/clinical safety of treatment with the device and the antitumor effect following treatment with the device.

What is being tested

EUS-Guided MWA Device (device)

Sponsor: Banner Health · Participants: 75 · Started: Feb 19, 2026

Contact the study team

Neil Sharma, MD · Phone: (480) 356 - 6444

Official record on ClinicalTrials.gov — NCT07817147

Locations in the U.S.

Arizona	Banner MD Anderson Cancer Center and Gateway Hospital, Gilbert
California	Cedars Sinai, Los Angeles (Not yet recruiting)
Illinois	Rush University Medical Center, Chicago (Not yet recruiting)
Minnesota	Mayo Clinic Rochester, Rochester (Not yet recruiting)
Tennessee	University of Tennessee Medical, Knoxville (Not yet recruiting)
Texas	Memorial Hermann-Texas Medical Center, Houston (Not yet recruiting)
West Virginia	West Virginia University Medicine, Morgantown (Not yet recruiting)

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.