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Breast Cancer clinical trials in Winston-Salem, NC

14 studies for Breast Cancer are looking for participants at sites in and around Winston-Salem (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Prospective Evaluation Of High-Dose Systemic Methotrexate In Patients With Breast Cancer And Leptomeningeal Metastasis

RecruitingPhase 2
  • Comprehensive Cancer Center at Wake Forest University (CCCWFU), Winston-Salem
Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT02422641

Distance-Based Exercise to Preserve Function and Prevent Disability

Recruiting
  • Novant Health Forsyth Medical Center, Winston-Salem
  • Novant Health Cancer Institute - Kernersville, Kernersville · 10 mi away
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT07059884

A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)

RecruitingPhase 3
  • Novant Health Oncology Specialists ( Site 0074), Winston-Salem
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07060807

Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

RecruitingPhase 3
  • Novant Health Forsyth Medical Center, Winston-Salem
  • Wake Forest University Health Sciences, Winston-Salem
  • Novant Health Colon and Rectal Clinic, Clemmons · 9 mi away
  • and 2 more
Ages 18 to 60 · Women · Updated Sep 2, 2026 · NCT05879926

A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy

RecruitingPhase 3
  • Research Site, Winston-Salem
Ages 18 to 130 · All sexes · Updated Aug 19, 2026 · NCT05774951

A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations

RecruitingPhase 2
  • Atrium Health Wake Forest Baptist - Comprehensive Cancer Center, Winston-Salem
Ages 8 and older · All sexes · Updated Jul 27, 2026 · NCT05503797

Personalized Exercise Program for Survivors of Breast Cancer, STEPS-BC Trial

Recruiting
  • Wake Forest NCORP RB, Winston-Salem
Ages 18 to 85 · All sexes · Updated Jun 15, 2026 · NCT07474090

I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

RecruitingPhase 2
  • Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT01042379

De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

RecruitingPhase 3
  • Novant Health Forsyth Medical Center, Winston-Salem
  • Wake Forest University Health Sciences, Winston-Salem
  • Wake Forest University at Clemmons, Clemmons · 9 mi away
  • and 1 more
Ages 50 to 70 · All sexes · Updated Apr 23, 2026 · NCT04852887

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

RecruitingObservational study
  • Wake Forest NCORP Research Base, Winston-Salem
  • Wake Forest University Health Sciences, Winston-Salem
  • Wake Forest University at Clemmons, Clemmons · 9 mi away
Ages 18 and older · All sexes · Updated Mar 17, 2026 · NCT06418204

EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD)

RecruitingObservational study
  • Atrium Health Wake Forest Baptist Medical Center, Winston-Salem
Ages 18 and older · All sexes · Updated Jan 20, 2026 · NCT06401421

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Winston-Salem
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

About Breast Cancer

Breast cancer is a cancer that starts in the breast tissue, when cells change and grow out of control. These extra cells can form a mass called a tumor.

More about Breast Cancer on MedlinePlus

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Other studies in Winston-Salem

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.