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Breast Cancer clinical trials in Houston, TX

126 studies for Breast Cancer are looking for participants at sites in and around Houston (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

Phase IIIb Study of Ribociclib + ET in Early Breast Cancer

RecruitingPhase 3
  • Kelsey Seybold Clinic, Houston
  • University of Texas, Houston
Ages 18 to 100 · All sexes · Updated Oct 2, 2026 · NCT05827081

A Study of Dato-DXd in Inoperable or Metastatic Hormone Receptor-positive, HER2 IHC 0 Breast Cancer

RecruitingPhase 3
  • Research Site, Houston
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT07205822

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • UT MD Anderson Cancer Center, Houston
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069

Prediction Of Lymphedema In Patients With Inflammatory BreastCancer Using Preoperative Bioimpedance Measurements

RecruitingObservational study
  • UT MD Anderson Cancer Center, Houston
Ages 18 and older · Women · Updated Oct 2, 2026 · NCT07855627

A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)

RecruitingPhase 2
  • The University of Texas MD Anderson Cancer Center - Texas Medical Center, Houston
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06760819

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 2
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06172478

A Phase 2 Neoadjuvant Study of Zanidatamab in Combination With Chemotherapy in Participants With HER2-positive Breast Cancer

RecruitingPhase 2
  • Texas Oncology Gulf Coast, Houston
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT07102381

Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

RecruitingPhase 1
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06625775

Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread

RecruitingPhase 1/2
  • The Methodist Hospital Research Institute, Houston
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT06324357

A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

RecruitingPhase 1
  • Research Site, Houston
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT05877599

BGB-43395 Alone or as Part of Combination Therapies in Participants With Breast Cancer and Other Advanced Solid Tumors

RecruitingPhase 1
  • The University of Texas Md Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT06120283

A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)

RecruitingPhase 3
  • Texas Oncology - Gulf Coast ( Site 8006), Houston
  • Oncology Consultants P.A. ( Site 0061), Houston
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07060807

An Investigational Study of BG-75202 Alone and in Combination With Other Therapeutic Agents in Adults With Advanced Solid Tumors

RecruitingPhase 1
  • The University of Texas Md Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07222267

Multicenter Trial for Eliminating Breast Cancer Surgery or Radiotherapy in Exceptional Responders to Neoadjuvant Systemic Therapy

Recruiting
  • M D Anderson Cancer Center, Houston
Ages 30 and older · Women · Updated Sep 25, 2026 · NCT02945579

Opioid-Sparing Effects of Nurse-Delivered Hypnosis During Breast Cancer Surgery

RecruitingPhase 2/3
  • M D Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT05766891

A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)

RecruitingPhase 3
  • Kelsey-Seybold Clinic ( Site 0042), Houston
  • Kelsey-Seybold Clinic ( Site 0088), Houston
  • Oncology Consultants P.A. ( Site 0073), Houston
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06966700

Group-based Comprehensive Lifestyle Program for Women With Metastatic Breast Cancer

Recruiting
  • The University of Texas M. D. Anderson Cancer Center, Houston
Ages 18 and older · Women · Updated Sep 25, 2026 · NCT07179809

ASPEN-09-03: A Study of Evorpacept in Combination With Trastuzumab and Chemotherapy in Metastatic HER2-Positive Breast Cancer

RecruitingPhase 2
  • Houston Methodist Cancer Center, Houston
  • The University of Texas M.D. Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07007559

TRAIL-R2 and HER2 Bi-Specific Chimeric Antigen Receptor (CAR) T Cells for the Treatment of Metastatic Breast Cancer

RecruitingPhase 1
  • Houston Methodist Hospital, Houston
Ages 18 to 80 · All sexes · Updated Sep 24, 2026 · NCT06251544

Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer

RecruitingPhase 3
  • Clinical Trial Site, Houston
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07085767

Signatera-Guided CDK4/6 Inhibitor Therapy in Breast Cancer

Recruiting
  • Houston Methodist Hospital, Houston
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07214532

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

RecruitingPhase 3
  • The University of Texas MD Anderson Cancer Center, Houston
  • Houston Methodist Hospital, Houston
  • Oncology Consultants P.A., Houston
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07174336

ARTIDIS Nanomechanical Generated Measurements for Early Breast Lesions

Recruiting
  • Baylor College of Medicine, Houston
  • MD Anderson Cancer Clinic - Mays Clinic, Houston
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06085833

A Study of LY4257496 in Participants With Cancer (OMNIRAY)

RecruitingPhase 1
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07114601

A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer

RecruitingPhase 2
  • University of Texas MD Anderson Cancer Center, Houston
  • Houston Methodist Hospital, Houston
  • Oncology Consultants P.A., Houston
Ages 18 and older · Women · Updated Sep 22, 2026 · NCT07287098

A Study of LY4337713 in Participants With FAP-Positive Solid Tumors

RecruitingPhase 1
  • Baylor College of Medicine, Houston
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07213791

Evolutionary Clinical Trial for Novel Biomarker-Driven Therapies

RecruitingPhase 2
  • Baylor College of Medicine, Houston
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT07340541

Fecal Microbiota Transplantation in Treating Immune-Checkpoint Inhibitor Induced-Diarrhea or Colitis in Genitourinary Cancer Patients

RecruitingPhase 1
  • M D Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT04038619

Magseed Enabled Long-Term Localization of Axillary Lymph Nodes

Recruiting
  • Baylor Medicine, Houston
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT03796559

ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-Negative Breast Cancer

RecruitingPhase 3
  • Oncology Consultants PA, Houston
  • Oncology Consultants PA, Houston
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07173751

A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations

RecruitingPhase 1/2
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07109726

A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence

RecruitingPhase 3
  • Oncology Consultants, P.A., Houston
  • The University of Texas MD Anderson Cancer Center, Houston
  • Harris Health System - Smith Clinic, Houston
  • and 1 more
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT06492616

Olaparib With Cediranib or AZD6738 for the Treatment of Advanced or Metastatic Germline BRCA Mutated Breast Cancer

RecruitingPhase 2
  • M D Anderson Cancer Center, Houston
Ages 18 and older · Women · Updated Sep 14, 2026 · NCT04090567

BGB-21447 (Bcl-2 Inhibitor) Combinations for Adults With Hormone-Receptor Positive (HR+)/Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Metastatic Breast Cancer

RecruitingPhase 1
  • Md Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT06756932

A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies

RecruitingPhase 1/2
  • Research Site, Houston
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT05123482

Study of Patritumab Deruxtecan Plus Pembrolizumab With Other Anticancer Agents in Participants With High-Risk Early-Stage Triple-Negative or Hormone Receptor-Low Positive/HER-2 Negative Breast Cancer (MK-1022-010, HERTHENA-Breast-03)

RecruitingPhase 2
  • Houston Methodist Hospital ( Site 0022), Houston
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06797635

Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors

RecruitingPhase 1
  • Oncology Consultants, Houston
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06293898

A Phase 1/1b Study of IAM1363 in HER2 Cancers

RecruitingPhase 1
  • MD Anderson Cancer Center - University of Texas, Houston
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06253871

A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors

RecruitingPhase 1
  • UT MD Anderson, Houston
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06440005

Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer

RecruitingPhase 1/2
  • University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT05386108

A Trial to Evaluate Ovarian Suppression Following Subcutaneous ZOLADEX 10.8 mg in Premenopausal Women With Early-stage and Advanced HR+ Breast Cancer

RecruitingPhase 1
  • Oncology Consultants PA, Houston
Ages 18 to 55 · Women · Updated Sep 9, 2026 · NCT07310420

A Study of LOXO-783 in Patients With Breast Cancer/Other Solid Tumors

RecruitingPhase 1
  • University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT05307705

A Study of Sofe-M in Participants With Selected Advanced Solid Tumors

RecruitingPhase 1
  • The University of Texas - MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT06400472

Study of AMXT 1501 and DFMO in Combination With Standard Therapies in Advanced Solid Tumors

RecruitingPhase 1/2
  • University of Texas-MD Anderson, Houston
  • Lumi Research, Houston
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT07287917

Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

RecruitingPhase 3
  • Houston Methodist Hospital Cancer Center, Houston
  • The University of Texas M.D. Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT06982521

Evaluating Minimal Residual Disease (MRD) Through Longitudinal Circulating Tumor DNA (ctDNA) Profiling in Breast Malignancies

RecruitingObservational study
  • UT Health Houston, Houston
Ages 18 to 99 · All sexes · Updated Sep 3, 2026 · NCT07211178

FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors

RecruitingPhase 1
  • M. D. Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT07216105

Improving Survival for Metastatic Lobular Breast Cancer (PLUMB Registry)

RecruitingObservational study
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT05964504

Shortening Adjuvant Photon and Proton Irradiation (SAPPHIRe-II): A 4 Cohort, Randomized, Phase II Multi-center Trial Evaluating Shorter Schedules of Adjuvant Regional Nodal Irradiation Among Women and Men With Node-positive and High-risk Node-negative Invasive Breast Cancer

RecruitingPhase 2
  • The University of Texas M. D. Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT07076485

Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

RecruitingPhase 3
  • Lyndon Baines Johnson General Hospital, Houston
  • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston
  • Ben Taub General Hospital, Houston
  • and 5 more
Ages 18 to 60 · Women · Updated Sep 2, 2026 · NCT05879926

A Study With NKT5097 for Adults With Advanced/Metastatic Solid Tumors

RecruitingPhase 1
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Aug 28, 2026 · NCT07029399

Study of ECI830 Single Agent or in Combination in Patients With Advanced HR+/HER2- Breast Cancer and in Patients With Other Advanced Solid Tumors

RecruitingPhase 1/2
  • MD Anderson Cancer Center Uni of Te, Houston
Ages 18 to 100 · All sexes · Updated Aug 27, 2026 · NCT06726148

TReatment of ADC-Refractory Breast CancEr With Dato-DXd or T-DXd: TRADE DXd

RecruitingPhase 2
  • Baylor College of Medicine, Houston
Ages 18 and older · All sexes · Updated Aug 26, 2026 · NCT06533826

Phase Ib Study of AlpeliSib With PEmbroLizumab in Patients With mEtastatic Breast caNcer or melanomA (SELENA)

RecruitingPhase 1
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Aug 25, 2026 · NCT06545682

A Phase 2 Single-Arm Open-Label Pilot Trial Evaluating Zanidatamab (ZW25) in Patients With Early Stage HER2/Neu Positive (HER2+) Breast Cancer (BC)

RecruitingPhase 2
  • M D Anderson Cancer Center, Houston
Ages 18 and older · Women · Updated Aug 24, 2026 · NCT05035836

A Pivotal Phase II Clinical Trial of Utidelone Injection Plus Capecitabine in HER2-negative Breast Cancer Patients With Brain Metastases

RecruitingPhase 2
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Aug 21, 2026 · NCT06764940

A Phase 1 Study of LNCB74 in Advanced Solid Tumors

RecruitingPhase 1
  • MD Anderson, Houston
Ages 18 and older · All sexes · Updated Aug 21, 2026 · NCT06774963

ATEMPT 2.0: Adjuvant T-DM1 vs TH

RecruitingPhase 2
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT04893109

Serial Imaging of the Novel Radiotracer [^18F] FLuorthanatrace ([^18F] FTT) by PET/CTF

RecruitingPhase 1
  • M D Anderson Cancer Center, Houston
Ages 18 and older · Women · Updated Aug 19, 2026 · NCT03604315

Social and Environmental Determinants of Breast Cancer Survivorship: the Black Breast Cancer Survivor's Intervention (BBCSI)

Recruiting
  • The University of Texas M. D. Anderson Cancer Center, Houston
Ages 18 and older · Women · Updated Aug 12, 2026 · NCT06885203

Study of AZD9574 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid Malignancies

RecruitingPhase 1/2
  • Research Site, Houston
Ages 18 to 130 · All sexes · Updated Aug 12, 2026 · NCT05417594

A Study of MGC026 in Participants With Advanced Solid Tumors

RecruitingPhase 1
  • The University of Texas MD Anderson Cancer Center, Houston
  • University of Texas Health Science Center at Houston, Houston
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT06242470

Mammography, Early Detection Biomarkers, Risk Assessment, and Imaging Technologies, MERIT Study

RecruitingObservational studyHealthy volunteers welcome
  • M D Anderson Cancer Center, Houston
Ages 25 to 80 · Women · Updated Aug 11, 2026 · NCT03408353

A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)

RecruitingPhase 2/3
  • (USOR) Texas Oncology, Houston
Ages 18 and older · All sexes · Updated Aug 10, 2026 · NCT06926868

Connecting Black Families in Houston, Texas to Hereditary Cancer Genetic Counseling, Genetic Testing, and Cascade Testing by Using a Simple Genetic Risk Screening Tool and Telegenetics

RecruitingHealthy volunteers welcome
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Aug 10, 2026 · NCT05694559

Surveillance MRI Registry for Patients Who Had Breast Cancer With Dense Breast Tissue

RecruitingObservational study
  • MD Anderson Cancer Center, Houston
Ages 18 and older · Women · Updated Aug 10, 2026 · NCT06127797

Phase 3 Study to Evaluate the Efficacy and Safety of HER2/Neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/Neu Positive Subjects

RecruitingPhase 3
  • Baylor College of Medicine - Dan L. Duncan Comprehensive Cancer Center, Houston
Ages 18 to 100 · All sexes · Updated Aug 6, 2026 · NCT05232916

IDOV-Immune for Advanced Solid Tumors

RecruitingPhase 1
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT06910657

Testing the Safety and Efficacy of the Combination of Two Anti-cancer Drugs, ZEN003694 and Abemaciclib, for Adult and Pediatric Patients (12-17 Years) With Metastatic or Unresectable NUT Carcinoma, Breast Cancer and Other Solid Tumors

RecruitingPhase 1
  • UT MD Anderson Cancer Center, Houston
Ages 12 and older · All sexes · Updated Jul 31, 2026 · NCT05372640

Comparison of Breast Cancer Screening With CESM to DBT in Women With Dense Breasts

RecruitingHealthy volunteers welcome
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 45 to 74 · Women · Updated Jul 31, 2026 · NCT05625659

A Phase Ib Study of Novel Combination (New) of Low Dose Oral CyclophoSphamide (s) to Potentiate Axatilimab (A) + Retifanlimab (R) in Treating Metastatic Triple Negative Breast Cancer (TNBC)

RecruitingPhase 1
  • The University of Texas M. D. Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jul 30, 2026 · NCT06959537

Phase I Study of [177Lu]Lu-NNS309 in Patients With Pancreatic, Lung, Breast and Colorectal Cancers

RecruitingPhase 1
  • Uni Of TX MD Anderson Cancer Cntr, Houston
Ages 18 to 100 · All sexes · Updated Jul 29, 2026 · NCT06562192

Finding the Best Tamoxifen Dose for Breast Cancer Risk Reduction in Premenopausal Women, RENAISSANCE Trial

RecruitingPhase 2
  • UT MD Anderson Cancer Center, Houston
Ages 18 to 55 · Women · Updated Jul 27, 2026 · NCT06184750

A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations

RecruitingPhase 2
  • University of Texas MD Anderson Cancer Center, Houston
Ages 8 and older · All sexes · Updated Jul 27, 2026 · NCT05503797

A Study to Learn About the Study Medicine Called PF-08032562 in People With Advanced or Metastatic Solid Tumors

RecruitingPhase 1
  • The University of Texas - M.D. Anderson Cancer Center, Houston
  • The University of Texas, MD Anderson Cancer Center - West Houston, Houston
Ages 18 and older · All sexes · Updated Jul 22, 2026 · NCT07318805

Study of RGT-490 in Patients With PIK3CA-Mutated Advanced Solid Tumors

RecruitingPhase 1
  • The University of Texas MD Anderson Cancer Center, Houston
  • NEXT Houston, Houston
Ages 18 and older · All sexes · Updated Jul 22, 2026 · NCT07524322

Phase I Study of Tumor Treating Fields (TTF) in Combination With Cabozantinib or With Pembrolizumab and Nab-Paclitaxel in Patients With Advanced Solid Tumors Involving the Abdomen or Thorax

RecruitingPhase 1
  • M D Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jul 16, 2026 · NCT05092373

The C-MERIT Screening Cohort: Contrast-enhanced Mammography for Breast Cancer Screening and Risk Assessment in Women With Dense Breasts

Recruiting
  • M D Anderson Cancer Center, Houston
Ages 30 to 75 · Women · Updated Jul 16, 2026 · NCT05667532

A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors

RecruitingPhase 2
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jul 10, 2026 · NCT06695845

First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jul 7, 2026 · NCT05768139

Improving Comprehensive Care of Cancer Patients

RecruitingHealthy volunteers welcome
  • Baylor College of Medicine, Houston
Ages 18 and older · All sexes · Updated Jun 30, 2026 · NCT05323409

A Study of Emiltatug Ledadotin (Emi-Le) in Participants With Solid Tumors

RecruitingPhase 1/2
  • MD Anderson, Houston
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT05377996

Phase 1/2 Study of ETX-636 in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jun 23, 2026 · NCT06993844

Trial Of PreoperAtive Radiation (TOPAz): A Randomized Trial Comparing Hypofractionated Versus Conventionally Fractionated Preoperative Radiation Followed by Mastectomy With Immediate Autologous Breast Reconstruction With Integrated Nanomechanical Biomarker Evaluation

RecruitingPhase 3
  • M D Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jun 23, 2026 · NCT05774678

Evaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation

RecruitingPhase 3
  • Baylor College of Medicine, Houston
  • MD Anderson Cancer Center, Houston
  • Harris Health System - Smith Clinic, Houston
Ages 18 and older · All sexes · Updated Jun 22, 2026 · NCT05696626

Data Collection for the Assessment of Acute and Late Normal Tissue in Patients Treated With Proton Therapy

RecruitingObservational study
  • M D Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jun 12, 2026 · NCT00991094

Alpelisib/iNOS Inhibitor/Nab-paclitaxel in Patients With HER2 Negative Metaplastic Breast Cancer (MpBC)

RecruitingPhase 2
  • Houston Methodist Neal Cancer Center, Houston
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jun 4, 2026 · NCT05660083

Lymphovenous Bypass Procedure Before Underarm Lymph Node Surgery in Preventing Lymphedema in Patients With Inflammatory or Locally Advanced Non-inflammatory Breast Cancer or Melanoma

Recruiting
  • M D Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated May 26, 2026 · NCT03941756

Identifying Underserved Individuals inTexas With Hereditary Cancer Risk Using Mobile Mammography Units and Telegenetics.

Recruiting
  • M D Anderson Cancer Center, Houston
Ages 18 and older · Women · Updated May 22, 2026 · NCT05649072

Multi-center MRD Registry for Inflammatory Breast Cancer

RecruitingObservational study
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated May 20, 2026 · NCT06966050

Phase 3 Study of Gedatolisib as First-Line Treatment for Patients With HR-Positive, HER2-Negative Advanced Breast Cancer (VIKTORIA-2)

RecruitingPhase 3
  • University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated May 18, 2026 · NCT06757634

EMERALD: Endocrine Therapy oMission With Radiation in ER+ Breast Cancer: Assessing Quality of Life and Disease Control: a Prospective Phase II Trial

RecruitingPhase 2
  • The University of Texas M. D. Anderson Cancer Center, Houston
Ages 60 and older · Women · Updated May 15, 2026 · NCT06897488

Temporal Immunologic Changes With Hypofractionated Radiation-Induced DNA Damage in Breast Cancer

RecruitingObservational study
  • M D Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT05406232

A Study to Learn About the Study Medicine Called PF-07248144 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment.

RecruitingPhase 3
  • University of Texas MD Anderson Cancer Center, Houston
  • MD Anderson West Houston, Houston
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT07062965

Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors

RecruitingPhase 1/2
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT06239194

Evaluation of Talazoparib, a PARP Inhibitor, in Patients With Somatic BRCA Mutant Metastatic Breast Cancer: Genotyping Based Clinical Trial

RecruitingPhase 2
  • MD Anderson Cancer Center, Houston
Ages 18 and older · Women · Updated May 6, 2026 · NCT03990896

Neutrophil Extracellular Traps Formation in Breast Cancer Patients Taking Tamoxifen

RecruitingObservational studyHealthy volunteers welcome
  • M D Anderson Cancer Center, Houston
Ages 18 and older · Women · Updated May 1, 2026 · NCT05056857

De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

RecruitingPhase 3
  • Houston Methodist Hospital, Houston
  • M D Anderson Cancer Center, Houston
  • Methodist Willowbrook Hospital, Houston
  • and 2 more
Ages 50 to 70 · All sexes · Updated Apr 23, 2026 · NCT04852887

Negative Pressure Wound Therapy in Healing Abdominal Incision in Obese Patients Undergoing Breast Reconstruction Surgery

Recruiting
  • M D Anderson Cancer Center, Houston
Ages 18 and older · Women · Updated Apr 21, 2026 · NCT04003038

Comparison of Synthetic Mammography Versus Full-Field Digital Mammography in Image Interpretation and Performance Metrics

RecruitingObservational study
  • M D Anderson Cancer Center, Houston
Ages 18 and older · Women · Updated Apr 16, 2026 · NCT05056818

Comparative Performance of Molecular Breast Imaging (MBI) to Magnetic Resonance Imaging (MRI) of the Breast in Identifying and Excluding Breast Carcinoma in Women at High Risk for Breast Cancer

Recruiting
  • M D Anderson Cancer Center, Houston
Ages 18 and older · Women · Updated Apr 15, 2026 · NCT05042687

Biospecimen and Medical Data Collection and Tumor Biopsy in Creating Research Tissue Registry in Patients With Inflammatory or Invasive Breast Cancer

RecruitingObservational study
  • M D Anderson Cancer Center, Houston
  • MD Anderson in Katy, Houston
Ages 18 and older · All sexes · Updated Apr 15, 2026 · NCT00477100

Open-Label Study to Evaluate the Safety, Tolerability, PK, and Efficacy of INX-315 in Patients With Advanced Cancer

RecruitingPhase 1/2
  • Oncology Consultants, Houston
  • Next Oncology, Houston
Ages 18 and older · All sexes · Updated Apr 1, 2026 · NCT05735080

A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies

RecruitingPhase 1/2
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Mar 27, 2026 · NCT06395519

The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study

RecruitingObservational study
  • Md Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Mar 5, 2026 · NCT04075305

A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

RecruitingPhase 1
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Feb 13, 2026 · NCT06778863

Binary Oncolytic Adenovirus in Combination With HER2-Specific Autologous CAR VST, Advanced HER2 Positive Solid Tumors

RecruitingPhase 1
  • Baylor St. Luke's Medical Center, Houston
Ages 18 and older · All sexes · Updated Feb 6, 2026 · NCT03740256

Converting HR+ Breast Cancer Into an Individualized Vaccine

RecruitingPhase 2
  • Houston Methodist Cancer Center, Houston
Ages 18 to 90 · Women · Updated Jan 28, 2026 · NCT03804944

EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD)

RecruitingObservational study
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jan 20, 2026 · NCT06401421

Post-operative Radiotherapy Omission in Selected Patients With Early Breast Cancer Trial International VErsion (PROSPECTIVE)

Recruiting
  • Baylor St Luke's Medical Centre, Houston
Ages 50 and older · Women · Updated Jan 15, 2026 · NCT06445738

A Study of MT-4561 in Patients With Various Advanced Solid Tumors

RecruitingPhase 1/2
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Dec 11, 2025 · NCT06943521

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Houston
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors

RecruitingPhase 1/2
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 24, 2025 · NCT05941507

First-in-Human Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, as a Single Agent in Patients With Advanced Solid Tumors and in Combination With Endocrine Therapy +/- a CDK4/6 or CDK4 Inhibitor in Patients With Advanced Solid Tumors or Advanced Breast Cancer

RecruitingPhase 1
  • The University of Texas M.D. Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 22, 2025 · NCT05216432

TRUDI: TDXD+Durva in HER2+/Low IBC

RecruitingPhase 2
  • University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · Women · Updated Sep 19, 2025 · NCT05795101

A Phase 1 Study of XL309 (ISM3091) Alone and in Combination in Participants With Advanced Solid Tumors

RecruitingPhase 1
  • Exelixis Clinical Site #1, Houston
Ages 18 and older · All sexes · Updated Sep 5, 2025 · NCT05932862

MammaPrint, BluePrint, and Full-genome Data Linked With Clinical Data to Evaluate New Gene EXpression Profiles

RecruitingObservational study
  • Texas Oncology - Memorial City, Houston
  • Texas Oncology Willowbrook, Houston
Ages 18 and older · All sexes · Updated Aug 20, 2025 · NCT03053193

Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of BTX-9341 in Advanced and/or Metastatic Breast Cancer

RecruitingPhase 1
  • Biotheryx Investigative Site, Houston
Ages 18 and older · All sexes · Updated Jun 6, 2025 · NCT06515470

A Trial of AMXI-5001 for Treatment in Patients With Advanced Malignancies

RecruitingPhase 1/2
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated May 1, 2025 · NCT04503265

Correlation of Clinical Response to Pathologic Response in Patients With Early Breast Cancer

RecruitingPhase 2
  • Harris Health System - Smith Clinic, Houston
  • O'Quinn Medical Tower - McNair Campus - Dan L Duncan Comprehensive Cancer Center, Houston
Ages 18 and older · All sexes · Updated Feb 27, 2025 · NCT05020860

BostonGene and Exigent Genomic INsight Study

RecruitingObservational study
  • Oncology Consultants, Houston
Ages 18 and older · All sexes · Updated Feb 17, 2025 · NCT06272864

A Study of BTX-A51 in People With Advanced Solid Tumor and Breast Cancer

RecruitingPhase 1
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jan 30, 2025 · NCT04872166

CtDNA Based MRD Testing for NAC Monitoring in TNBC

RecruitingObservational study
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · Women · Updated Jan 7, 2025 · NCT06230185

Comprehensive Outcomes for After Cancer Health

RecruitingHealthy volunteers welcome
  • The University of Texas MD Anderson Cancer Center, Houston
  • UT Health Houston, Houston
Ages 18 and older · All sexes · Updated Dec 11, 2024 · NCT05349227

Delayed Sentinel Lymph Node Biopsy in Ductal Cancer in Situ

RecruitingPhase 3
  • Baylor College Of Medicine, Houston
Ages 18 and older · Women · Updated Aug 3, 2023 · NCT04722692

About Breast Cancer

Breast cancer is a cancer that starts in the breast tissue, when cells change and grow out of control. These extra cells can form a mass called a tumor.

More about Breast Cancer on MedlinePlus

Breast Cancer trials in other cities

Other studies in Houston

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.