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Alpha-1 Antitrypsin Deficiency clinical trials recruiting in the U.S.
14 studies for Alpha-1 Antitrypsin Deficiency are recruiting participants at sites across the United States.
Alpha-1 Antitrypsin Deficiency is an inherited condition that raises your risk for lung and liver disease. Learn about the symptoms and treatment.
Cities with the most studies
- Charleston, SC6 studies
- Gainesville, FL6 studies
- Birmingham, AL5 studies
- Boston, MA4 studies
- Rochester, MN4 studies
- New York City, NY4 studies
- Cleveland, OH3 studies
- Los Angeles, CA3 studies
- Phoenix, AZ3 studies
- Miami, FL3 studies
By state
- Alabama5 studies
- Arizona3 studies
- California4 studies
- Colorado3 studies
- Florida9 studies
- Massachusetts4 studies
- Minnesota4 studies
- New York4 studies
- Ohio3 studies
- South Carolina6 studies
- Texas4 studies
Recently updated studies
Gene Therapy for Alpha 1- Antitrypsin Deficiency
RecruitingPhase 1
Ages 18 to 70 · All sexes · Updated Sep 25, 2026 · NCT06996756A Study of TSRA-196 in Adults With PiZZ Alpha-1 Antitrypsin Deficiency (AATD)
RecruitingPhase 1/2
Ages 18 to 70 · All sexes · Updated Sep 24, 2026 · NCT07227207Role of Genetic Factors in the Development of Lung Disease
RecruitingObservational studyHealthy volunteers welcome
Ages 2 to 90 · All sexes · Updated Sep 10, 2026 · NCT00001532Alpha-1 Research Registry
RecruitingObservational study
All ages · All sexes · Updated Aug 19, 2026 · NCT04157049A Non-inferiority Pharmacokinetic and Safety/Tolerability Study of Two Different Doses of Weekly SC Alpha1-PI 15% Compared With Corresponding Standard IV Alpha1-PI in Participants With Alpha1-Antitrypsin Deficiency (AATD)
RecruitingPhase 3
Ages 18 to 80 · All sexes · Updated Aug 11, 2026 · NCT07555483A Study in Adults to Learn About Inherited Alpha-1 Antitrypsin Deficiency (AATD) and AATD Related Liver Problems
RecruitingObservational study
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT06512454Study to Check the Safety of Fazirsiran and Learn if Fazirsiran Can Help People With Liver Disease and Scarring (Fibrosis) Due to an Abnormal Version of Alpha-1 Antitrypsin Protein
RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated May 13, 2026 · NCT05677971A Study to Evaluate the Safety and Efficacy of BEAM-302 in Adult Patients With Alpha-1 Antitrypsin Deficiency (AATD)
RecruitingPhase 1/2
Ages 18 to 70 · All sexes · Updated Mar 20, 2026 · NCT06389877Study to Learn About the Safety of Fazirsiran and if it Can Help People With Alpha-1 Antitrypsin Liver Disease With Mild Liver Scarring (Fibrosis)
RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Mar 5, 2026 · NCT06165341PiMZ Longitudinal Cohort (PiMZ Logic)
RecruitingObservational study
Ages 18 and older · All sexes · Updated Jan 16, 2026 · NCT06505603The Alpha-1 Foundation's and University of Florida's Alpha-1 Coded Testing (ACT) Study
RecruitingObservational studyHealthy volunteers welcome
All ages · All sexes · Updated Nov 24, 2025 · NCT00500123Genetic Variation in IgG in Alpha 1 Antitrypsin Deficiency
RecruitingPhase 4
Ages 19 and older · All sexes · Updated Nov 10, 2025 · NCT07135427Lung Disease and Its Affect on the Work of White Blood Cells in the Lungs
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Nov 6, 2025 · NCT01851642A Study of KB408 for the Treatment of Alpha-1 Antitrypsin Deficiency
RecruitingPhase 1
Ages 18 to 70 · All sexes · Updated Jul 22, 2025 · NCT06049082From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.