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Alpha-1 Antitrypsin Deficiency clinical trials recruiting in the U.S.

14 studies for Alpha-1 Antitrypsin Deficiency are recruiting participants at sites across the United States.

Alpha-1 Antitrypsin Deficiency is an inherited condition that raises your risk for lung and liver disease. Learn about the symptoms and treatment.

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Recently updated studies

Gene Therapy for Alpha 1- Antitrypsin Deficiency

RecruitingPhase 1
Ages 18 to 70 · All sexes · Updated Sep 25, 2026 · NCT06996756

A Study of TSRA-196 in Adults With PiZZ Alpha-1 Antitrypsin Deficiency (AATD)

RecruitingPhase 1/2
Ages 18 to 70 · All sexes · Updated Sep 24, 2026 · NCT07227207

Role of Genetic Factors in the Development of Lung Disease

RecruitingObservational studyHealthy volunteers welcome
Ages 2 to 90 · All sexes · Updated Sep 10, 2026 · NCT00001532

Alpha-1 Research Registry

RecruitingObservational study
All ages · All sexes · Updated Aug 19, 2026 · NCT04157049

A Study in Adults to Learn About Inherited Alpha-1 Antitrypsin Deficiency (AATD) and AATD Related Liver Problems

RecruitingObservational study
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT06512454

A Study to Evaluate the Safety and Efficacy of BEAM-302 in Adult Patients With Alpha-1 Antitrypsin Deficiency (AATD)

RecruitingPhase 1/2
Ages 18 to 70 · All sexes · Updated Mar 20, 2026 · NCT06389877

PiMZ Longitudinal Cohort (PiMZ Logic)

RecruitingObservational study
Ages 18 and older · All sexes · Updated Jan 16, 2026 · NCT06505603

The Alpha-1 Foundation's and University of Florida's Alpha-1 Coded Testing (ACT) Study

RecruitingObservational studyHealthy volunteers welcome
All ages · All sexes · Updated Nov 24, 2025 · NCT00500123

Genetic Variation in IgG in Alpha 1 Antitrypsin Deficiency

RecruitingPhase 4
Ages 19 and older · All sexes · Updated Nov 10, 2025 · NCT07135427

Lung Disease and Its Affect on the Work of White Blood Cells in the Lungs

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Nov 6, 2025 · NCT01851642

A Study of KB408 for the Treatment of Alpha-1 Antitrypsin Deficiency

RecruitingPhase 1
Ages 18 to 70 · All sexes · Updated Jul 22, 2025 · NCT06049082

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.