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Alzheimer's Disease clinical trials in Massachusetts
45 studies for Alzheimer's Disease are looking for participants at sites in Massachusetts.
Cities in Massachusetts
A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)
- Boston Center for Memory, Newton
- Local Institution - 2615, Worcester
RecruitingPhase 3
Ages 55 to 90 · All sexes · Updated Sep 28, 2026 · NCT06937229A Study of Zunveyl on Safety, Tolerability, Neuropsychiatric Symptoms, and Caregiver Distress in Alzheimer's Disease (RESOLVE)
- ActivMed Practices & Research, LLC, Methuen
- Adams Clinical - Watertown, Watertown
RecruitingPhase 4
Ages 50 and older · All sexes · Updated Sep 25, 2026 · NCT07633470Dominantly Inherited Alzheimer Network (DIAN)
- Brigham and Women's Hospital, Boston
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT00869817Improving Memory in Alzheimer's Disease With Noninvasive Brain Stimulation
- 111 Cummington Mall. Room 264, Boston
RecruitingHealthy volunteers welcome
Ages 50 to 100 · All sexes · Updated Sep 23, 2026 · NCT06094192A Study of Donanemab (LY3002813) in Participants With Early Cognitive Decline (TRAILBLAZER-ALZ 7)
- Massachusetts General Hospital - Charlestown, Charlestown
- K2 Medical Research - Foxborough, Foxborough
- Neurology Center of New England, Foxborough
- and 1 more
RecruitingPhase 2
Ages 55 to 85 · All sexes · Updated Sep 22, 2026 · NCT07589595A Study to Investigate the Safety and Effectiveness of SAR448851 in Participants With Early Alzheimer's Disease
- Boston Center for Memory - Newton- Site Number : 8400007, Newton
RecruitingPhase 2
Ages 55 to 85 · All sexes · Updated Sep 22, 2026 · NCT07688213A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)
- McLean Hospital, Belmont
- Tufts Medical Center - 800 Washington St - PPDS, Boston
- Boston Neuro Research Center, North Dartmouth
- and 1 more
RecruitingPhase 3
Ages 55 to 90 · All sexes · Updated Sep 22, 2026 · NCT06585787Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies
- Adams Clinical Boston, Boston
- Boston Center for Memory, Newton
- Adams Clinical Watertown, Watertown
RecruitingPhase 3
Ages 50 to 90 · All sexes · Updated Sep 21, 2026 · NCT07177352Study of LHP588 in Subjects With P. Gingivalis-Positive Alzheimer's Disease
- Adams Clinical Boston, Boston
- Headlands Research-EMA, Plymouth
- Adams Clinical Watertown, Watertown
RecruitingPhase 2
Ages 55 to 80 · All sexes · Updated Sep 21, 2026 · NCT06847321A Study to Assess the Safety and Effects of ABBV-1758 Following Subcutaneous or Intravenous Injections in Participants With Alzheimer's Disease
- Adams Clinical /ID# 277754, Watertown
RecruitingPhase 1/2
Ages 50 to 90 · All sexes · Updated Sep 18, 2026 · NCT07599670A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease (MINDSET 2)
- Local Institution - 0080, Watertown
RecruitingPhase 3
Ages 60 to 85 · All sexes · Updated Sep 17, 2026 · NCT06976203A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-1)
- Local Institution - 1663, Foxborough
- Boston Center for Memory, Newton
- Mayflower Clinical Research, South Dartmouth
- and 1 more
RecruitingPhase 3
Ages 55 to 90 · All sexes · Updated Sep 16, 2026 · NCT07011732The BRAIN App (Phase 2 SBIR)
- Hopeful Aging, Winchester
Recruiting
Ages 65 and older · All sexes · Updated Sep 15, 2026 · NCT06298474Making Connections Thru Music
- Hopeful Aging, Winchester
- The Hearthstone Institute, LLC, Winchester
RecruitingHealthy volunteers welcome
Ages 18 to 103 · All sexes · Updated Sep 15, 2026 · NCT06079216Tau PET/CT Imaging in the Mismatch Prospective Cohort Study (MPC-TAU)
- Massachusetts General Hospital, Boston
RecruitingObservational study
Ages 18 to 120 · All sexes · Updated Sep 4, 2026 · NCT05658913Contributions of mTBI to Neurodegeneration Due to Chronic Traumatic Encephalopathy (CTE) and Alzheimer's Disease (AD)
- VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston
RecruitingObservational studyHealthy volunteers welcome
Ages 30 to 90 · All sexes · Updated Sep 1, 2026 · NCT04124029Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986368, for the Treatment of Agitation in Participants With Alzheimer's Disease
- K2 Medical Research, Foxborough
- Local Institution - 0051, South Dartmouth
RecruitingPhase 2
Ages 55 to 90 · All sexes · Updated Sep 1, 2026 · NCT06808984A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)
- Boston Center for Memory ( Site 1008), Newton
RecruitingPhase 2
Ages 50 to 85 · All sexes · Updated Aug 26, 2026 · NCT07033494A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's Disease
- Massachusetts General Hospital (MGH), Charlestown
RecruitingPhase 1
Ages 50 to 85 · All sexes · Updated Aug 24, 2026 · NCT06297590A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease
- Boston Center for Memory, Newton
RecruitingPhase 3
Ages 60 to 85 · All sexes · Updated Aug 20, 2026 · NCT06976216Use of a Mobile Brain-Body Imaging Approach to Evaluate the Effects of Rhythmic Auditory Stimulation on Gait and Brain Function in Alzheimer's Disease
- Boston University Neuromotor Recovery Laboratory, Boston
RecruitingHealthy volunteers welcome
Ages 50 to 90 · All sexes · Updated Aug 13, 2026 · NCT07659964Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant
- Massachusetts General Hospital, Boston
- Brigham and Women's Hospital, Boston
- Boston University (BU) School of Medicine, Boston
RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Aug 4, 2026 · NCT06563895Home-Based Brain Stimulation for Motoric Cognitive Risk Syndrome
- Hebrew Rehabilitation Center, Roslindale
Recruiting
Ages 65 to 90 · All sexes · Updated Jul 16, 2026 · NCT06821568Individual Closed-Loop Neuromodulation Therapy for Alzheimer's Disease
- Massachusetts General Hospital, Charlestown
RecruitingHealthy volunteers welcome
Ages 50 to 80 · All sexes · Updated Jul 14, 2026 · NCT05904132A Study of Donanemab (LY3002813) in Participants Who Completed Study AACM (TRAILBLAZER-ALZ 3-EXT).
- Boston Center for Memory, Newton
- MedVadis Research Corporation, Waltham
RecruitingPhase 3
Ages 55 and older · All sexes · Updated Jul 7, 2026 · NCT07602582A Clinical Trial to Learn About the Effects of VHB937 in People With Early Alzheimer's Disease
- ActivMed Practices and Research, Methuen
RecruitingPhase 2
Ages 50 to 85 · All sexes · Updated Jun 26, 2026 · NCT07094516Gamma Light and Sound Stimulation to Prevent Dementia in Cognitively Normal People at Risk for Alzheimer's Disease
- Massachusetts General Hospital, Boston
- Massachusetts Institute of Technology, Cambridge
RecruitingHealthy volunteers welcome
Ages 55 to 90 · All sexes · Updated Jun 18, 2026 · NCT05776641Biomarker-based Trial of NPC-1 for Alzheimer's Pathology
- Massachusetts General Hospital, Boston
RecruitingPhase 2
Ages 55 and older · All sexes · Updated Jun 8, 2026 · NCT07236190[18F]PI-2620 Phase 3 Histopathological Study
- Alzheimer's Disease Center, Braintree
RecruitingPhase 3
Ages 50 and older · All sexes · Updated May 22, 2026 · NCT05641688Trial-Ready Cohort-Down Syndrome (TRC-DS)
- Massachusetts General Hospital, Co-Enrolling through ABC-DS Only, Boston
RecruitingObservational study
Ages 25 to 55 · All sexes · Updated May 18, 2026 · NCT04165109Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease
- Massachusetts General Hospital, Boston
RecruitingEarly phase 1Healthy volunteers welcome
Ages 40 to 99 · All sexes · Updated May 6, 2026 · NCT06538311Cognitive Neurology Unit Clinical Registry
- Beth Israel Deaconess Medical Center, Boston
RecruitingObservational study
Ages 50 to 95 · All sexes · Updated Apr 13, 2026 · NCT05925621Gamma Frequency Stimulation in Individuals With Down Syndrome
- Massachusetts Institute of Technology, Cambridge
RecruitingHealthy volunteers welcome
Ages 25 to 65 · All sexes · Updated Mar 31, 2026 · NCT05196984Chronic Treatment of Alzheimer's Disease by Gamma Light and Sound Therapy
- Massachusetts Institute of Technology, Cambridge
RecruitingHealthy volunteers welcome
Ages 65 to 100 · All sexes · Updated Mar 30, 2026 · NCT05655195Brain Effects of Gamma Frequency Sensory Stimulation (40Hz Light, Sound and Other Devices)
- MIT, Cambridge
RecruitingPhase 2Healthy volunteers welcome
Ages 18 to 100 · All sexes · Updated Mar 27, 2026 · NCT07496918Digital Accessible Remote Olfactory Mediated Health Assessments for Preclinical AD
- Massachusetts General Hospital, Boston
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 100 · All sexes · Updated Mar 6, 2026 · NCT05881239Assessment of Foralumab Safety and Modulation of Microglial Activation in Alzheimer's Disease
- Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Boston
RecruitingPhase 2
Ages 60 to 85 · All sexes · Updated Feb 12, 2026 · NCT06489548PET Brain Imaging in Multiple Sclerosis, Alzheimer's Disease, and Other Neurological and Neuropsychiatric Diseases
- Brigham MS Center, 60 Fenwood Road, Boston
RecruitingPhase 1/2Healthy volunteers welcome
Ages 18 to 85 · All sexes · Updated Jan 28, 2026 · NCT02649985Non-invasive Brain Stimulation for Cognitive and Motor Dysfunction in Dementia
- Hinda and Arthur Marcus Institute for Aging Research, Boston
Recruiting
Ages 55 and older · All sexes · Updated Jan 12, 2026 · NCT05661084Trial to Reduce Antimicrobial Use in Nursing Home Residents With Alzheimer's Disease and Other Dementias 2.0
- Hebrew SeniorLife, Boston
Recruiting
Ages 60 to 106 · All sexes · Updated Jan 6, 2026 · NCT05950607From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.