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Breast Cancer clinical trials in Miami, FL

42 studies for Breast Cancer are looking for participants at sites in and around Miami (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

A Trial to Evaluate Ovarian Suppression Following Subcutaneous ZOLADEX 10.8 mg in Premenopausal Women With Early-stage and Advanced HR+ Breast Cancer

RecruitingPhase 1
  • Regis Clinical Research, Miami
Ages 18 to 55 · Women · Updated Nov 12, 2026 · NCT07310420

ASPEN-09-03: A Study of Evorpacept in Combination With Trastuzumab and Chemotherapy in Metastatic HER2-Positive Breast Cancer

RecruitingPhase 2
  • Sylvester Comprehensive Cancer Center, Miami
Ages 18 and older · All sexes · Updated Nov 9, 2026 · NCT07007559

A Multilevel Approach to Connecting Underrepresented Populations to Clinical Trials

RecruitingObservational studyHealthy volunteers welcome
  • University of Miami, Miami
Ages 18 to 100 · All sexes · Updated Nov 5, 2026 · NCT05655494

Signatera-Guided CDK4/6 Inhibitor Therapy in Breast Cancer

Recruiting
  • Werheim Cancer Institute, Miami
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT07214532

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

RecruitingPhase 3
  • University of Miami Hospital and Clinics, Sylvester Cancer Center, Miami
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07174336

E-Mindfulness Approaches for Living After Breast Cancer

RecruitingPhase 3
  • University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami
  • UM Sylvester Comprehensive Cancer Center at Kendall, Miami
Ages 18 to 50 · All sexes · Updated Nov 4, 2026 · NCT06748222

Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

RecruitingPhase 3
  • University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami
  • Miami Cancer Institute, Miami
  • UM Sylvester Comprehensive Cancer Center at Kendall, Miami
Ages 18 to 60 · Women · Updated Nov 4, 2026 · NCT05879926

The CDK4/6 Inhibitor Dosing Knowledge (CDK) Study

RecruitingPhase 3
  • Miami Cancer Institute, Miami
Ages 60 and older · All sexes · Updated Nov 2, 2026 · NCT06377852

BRain-AVOidant Proton Craniospinal Irradiation for Leptomeningeal Metastases From Solid Tumor Malignancies

Recruiting
  • University of Miami, Miami
Ages 18 and older · All sexes · Updated Oct 23, 2026 · NCT07789912

Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors

RecruitingPhase 1/2
  • Sylvester Comprehensive Cancer Center - University of Miami Health System, Miami
Ages 18 and older · All sexes · Updated Oct 15, 2026 · NCT06239194

Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors

RecruitingPhase 1
  • University of Miami, Miami
Ages 18 and older · All sexes · Updated Oct 13, 2026 · NCT06293898

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • University of Miami - Sylvester Comprehensive Cancer Center, Miami
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

Conventionally Fractionated vs. Hypofractionated Comprehensive Nodal Irradiation for Breast Cancer Using Pencil Beam Scanning Proton Therapy

RecruitingPhase 3
  • Dwoskin Proton Therapy Center, Miami
  • Miami Cancer Institute, Miami
Ages 19 and older · Women · Updated Sep 29, 2026 · NCT05856773

A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • University of Miami Hospital and Clinics, Sylvester Cancer Center, Miami
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT06618287

Precise Oncology Interventions in Nutrition and Training (OnPoint)

RecruitingHealthy volunteers welcome
  • University of Miami, Miami
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT06534918

Study of 3-Day Partial Breast Radiation Therapy in Women With Breast Cancer

RecruitingPhase 2
  • Baptist Alliance Miami Cancer Institute, Miami
Ages 45 and older · Women · Updated Sep 21, 2026 · NCT04084730

Women Informed to Screen Depending on Measures of Risk (Wisdom Study)

RecruitingHealthy volunteers welcome
  • TopLine MD Alliance, Miami
Ages 30 to 74 · Women · Updated Sep 21, 2026 · NCT02620852

A Study of Breast Cancer Risk Factors and Outcomes of People in Florida

RecruitingObservational studyHealthy volunteers welcome
  • University of Miami (Data Collection Only), Miami
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT06780176

A Study of SDX-7320 in Combination With Eribulin for People With Breast Cancer

RecruitingPhase 2
  • BAPTIST ALLIANCE - MCI (Data Collection Only), Miami
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT05570253

A Phase 1/1b Study of IAM1363 in HER2 Cancers

RecruitingPhase 1
  • University of Miami, Miami
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06253871

Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.

RecruitingPhase 3
  • University Of Miami-SCCC-Miami, Miami
  • University of Miami_SCCC - Kendall, Miami
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT06072612

ATEMPT 2.0: Adjuvant T-DM1 vs TH

RecruitingPhase 2
  • Miami Cancer Institute/Baptist Hospital of Miami, Miami
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT04893109

Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial

RecruitingPhase 3
  • University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami
  • Miami Cancer Institute, Miami
  • UM Sylvester Comprehensive Cancer Center at Kendall, Miami
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT06500481

Sequencing Antibody Drug Conjugates in ER+/HER2 LOW/ULTRA LOW MBC

RecruitingPhase 2
  • Baptist Health Herbert Wertheim Cancer Institute, Miami
Ages 18 and older · All sexes · Updated Aug 12, 2026 · NCT06263543

Phase 3 Study to Evaluate the Efficacy and Safety of HER2/Neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/Neu Positive Subjects

RecruitingPhase 3
  • University of Miami - Sylvester Comprehensive Cancer Center, Miami
Ages 18 to 100 · All sexes · Updated Aug 6, 2026 · NCT05232916

DATO-BASE: DATOpotamab-deruxtecan for Breast Cancer Brain metAstaSEs

RecruitingPhase 2
  • Miami Baptist Cancer Institute/, Miami
Ages 18 and older · All sexes · Updated Aug 6, 2026 · NCT06176261

SABER Study for Selected Early Stage Breast Cancer

Recruiting
  • University of Miami, Miami
Ages 50 and older · Women · Updated Aug 3, 2026 · NCT04360330

A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations

RecruitingPhase 2
  • University of Miami Hospital and Clinics, Miami
Ages 8 and older · All sexes · Updated Jul 27, 2026 · NCT05503797

Phase III Trial of Brain MRI Surveillance in Stage IV Breast Cancer

RecruitingPhase 3
  • Baptist Health South Florida, Miami
Ages 18 and older · All sexes · Updated May 15, 2026 · NCT07357298

Sacituzumab Govitecan +/- Pembrolizumab in Metastatic TNBC

RecruitingPhase 2
  • Miami Cancer Institute at Baptist Health (Kendall), Miami
Ages 18 and older · All sexes · Updated Apr 29, 2026 · NCT04468061

De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

RecruitingPhase 3
  • University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami
Ages 50 to 70 · All sexes · Updated Apr 23, 2026 · NCT04852887

Evexomostat Plus PI3K or AKT Inhibitor and Fulvestrant in Patients With a PI3K Alteration and HR+/Her2- Breast Cancer

RecruitingPhase 1/2
  • Miami Cancer Institute at Baptist Health, Miami
Ages 18 and older · All sexes · Updated Apr 22, 2026 · NCT05455619

Application of Chinese Herbal Complementary and Alternative Medicine (CAM) to Improve Human Health and to Further Botanical and Horticultural Sciences

Recruiting
  • University of Miami, Miami
Ages 18 and older · Women · Updated Mar 27, 2026 · NCT04650256

With Love, Grandma ("Con Cariño, Abuelita") Pilot Study

Recruiting
  • University of Miami, Miami
Ages 21 and older · Women · Updated Feb 25, 2026 · NCT05721976

A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

RecruitingPhase 1
  • University of Miami - Sylvester Comprehensive Cancer Center, Miami
Ages 18 and older · All sexes · Updated Feb 13, 2026 · NCT06778863

Breast Re-irradiation After Second Ipsilateral Lumpectomy

Recruiting
  • Miami Cancer Institute at Baptist Health, Inc., Miami
Ages 40 and older · Women · Updated Nov 13, 2025 · NCT06867484

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Miami
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

MammaPrint, BluePrint, and Full-genome Data Linked With Clinical Data to Evaluate New Gene EXpression Profiles

RecruitingObservational study
  • Sylvester Comprehensive Cancer Center - University of Miami, Miami
  • Miami Cancer Institute at Baptist Health, Inc, Miami
Ages 18 and older · All sexes · Updated Aug 20, 2025 · NCT03053193

About Breast Cancer

Breast cancer is a cancer that starts in the breast tissue, when cells change and grow out of control. Learn about the types, diagnosis, and treatments.

More about Breast Cancer on MedlinePlus

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Other studies in Miami

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.