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Breast Cancer clinical trials in Springfield, MO

11 studies for Breast Cancer are looking for participants at sites in and around Springfield (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity

RecruitingPhase 3
  • Mercy Hospital Springfield, Springfield
  • CoxHealth South Hospital, Springfield
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT03418961

The Vanguard Study: Testing a New Way to Screen for Cancer

RecruitingHealthy volunteers welcome
  • CoxHealth South Hospital, Springfield
Ages 45 to 75 · All sexes · Updated Nov 6, 2026 · NCT06995898

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

RecruitingPhase 3
  • Oncology Hematology Associates, Springfield
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07174336

E-Mindfulness Approaches for Living After Breast Cancer

RecruitingPhase 3
  • Mercy Hospital Springfield, Springfield
Ages 18 to 50 · All sexes · Updated Nov 4, 2026 · NCT06748222

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • Mercy Hospital Springfield, Springfield
  • CoxHealth South Hospital, Springfield
Ages 40 to 75 · All sexes · Updated Nov 4, 2026 · NCT05334069

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

RecruitingObservational study
  • Mercy Hospital Springfield, Springfield
  • Cox Health South Hospital, Springfield
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT06418204

A Study of Alisertib in Combination With Endocrine Therapy in Patients With HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer

RecruitingPhase 2
  • Oncology Hematology Associates, Springfield
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06369285

Evaluating Minimal Residual Disease (MRD) Through Longitudinal Circulating Tumor DNA (ctDNA) Profiling in Breast Malignancies

RecruitingObservational study
  • Oncology Hematology Associates, Springfield
Ages 18 to 99 · All sexes · Updated Sep 3, 2026 · NCT07211178

Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial

RecruitingPhase 3
  • Mercy Hospital Springfield, Springfield
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT06500481

De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

RecruitingPhase 3
  • Mercy Hospital Springfield, Springfield
  • CoxHealth South Hospital, Springfield
Ages 50 to 70 · All sexes · Updated Apr 23, 2026 · NCT04852887

About Breast Cancer

Breast cancer is a cancer that starts in the breast tissue, when cells change and grow out of control. Learn about the types, diagnosis, and treatments.

More about Breast Cancer on MedlinePlus

Breast Cancer trials in other cities

Other studies in Springfield

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.