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Cystic Fibrosis clinical trials recruiting in the U.S.

63 studies for Cystic Fibrosis are recruiting participants at sites across the United States.

Cystic fibrosis (CF) is an inherited disease of the mucus and sweat glands. The symptoms and severity of CF can vary. Get the facts.

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Recently updated studies

Natural History of Bronchiectasis

RecruitingObservational studyHealthy volunteers welcome
Ages 5 to 100 · All sexes · Updated Nov 12, 2026 · NCT00943514

Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of SPL84 in Patients With Cystic Fibrosis

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT06429176

Sinonasal Therapies and Histologic Correlations of Patients With Cystic Fibrosis in the Era of Highly Effective Modulator Therapy

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT06996951

Natural History of Noncirrhotic Portal Hypertension

RecruitingObservational study
Ages 12 to 100 · All sexes · Updated Nov 9, 2026 · NCT02417740

Role of Genetic Factors in the Development of Lung Disease

RecruitingObservational studyHealthy volunteers welcome
Ages 2 to 90 · All sexes · Updated Nov 9, 2026 · NCT00001532

Streamlined Treatment of Pulmonary Exacerbations in Pediatrics

Recruiting
Ages 3 to 18 · All sexes · Updated Nov 9, 2026 · NCT06654752

TIDES 2.0: Prevalence and Longitudinal Course of Depression, Anxiety, and Behavior Problems in Children With Cystic Fibrosis Under 12 Years of Age

RecruitingObservational study
18 Months – 11 Years · All sexes · Updated Nov 3, 2026 · NCT07048574

Phase 2 Study to Assess the Safety and Efficacy of ANG003

RecruitingPhase 2
Ages 12 and older · All sexes · Updated Oct 30, 2026 · NCT07450547

Evaluation of VX-581 in Healthy Participants and in Participants With Cystic Fibrosis

RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 55 · All sexes · Updated Oct 19, 2026 · NCT07283770

Bacteriophages for Adults With Cystic Fibrosis and Chronic Achromobacter Lung Infection

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 8, 2026 · NCT07275905

Regional Phenotyping of CF and Non-CF Bronchiectasis

RecruitingObservational studyHealthy volunteers welcome
Ages 5 to 100 · All sexes · Updated Oct 7, 2026 · NCT04793867

Health Outcomes of Parents With Cystic Fibrosis-Aim 2

RecruitingObservational study
Ages 18 and older · All sexes · Updated Oct 7, 2026 · NCT06296394

Acoustic Waveform Respiratory Evaluation

RecruitingHealthy volunteers welcome
Ages 8 to 70 · All sexes · Updated Oct 5, 2026 · NCT06512064

Exercise in Child Health

RecruitingHealthy volunteers welcome
Ages 10 to 17 · All sexes · Updated Oct 2, 2026 · NCT05359991

Dose Escalation Study Evaluating the Safety and Pharmacokinetics of VX-272 in Healthy Participants

RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 55 · All sexes · Updated Sep 23, 2026 · NCT07437105

ATUSA Ultrasound Diagnostic Imaging for Breast Lesions Evaluation (AUDIBLE) - iSono Health

RecruitingObservational study
Ages 18 to 94 · Women · Updated Sep 17, 2026 · NCT07505797

Genetics of Insulin and Incretins in Cystic Fibrosis

RecruitingObservational study
Ages 2 and older · All sexes · Updated Sep 16, 2026 · NCT01852448

Impact of Sinus Surgery on Individuals With Cystic Fibrosis

RecruitingObservational study
Ages 18 to 99 · All sexes · Updated Sep 10, 2026 · NCT04469439

Sinus Disease in Young Children With Cystic Fibrosis

RecruitingObservational study
Ages 2 to 8 · All sexes · Updated Sep 10, 2026 · NCT06191640

Hormonal Responses to a Mixed Meal in People With Cystic Fibrosis

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 45 · All sexes · Updated Aug 25, 2026 · NCT06163482

Remote Sputum Collection in Cystic Fibrosis

RecruitingObservational study
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT06950892

Continuous Glucose Monitoring and OGTT Screen for Cystic Fibrosis Related Diabetes in Cystic Fibrosis

RecruitingObservational study
Ages 18 and older · All sexes · Updated Jul 31, 2026 · NCT06560463

Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study

RecruitingPhase 4
Ages 6 and older · All sexes · Updated Jul 8, 2026 · NCT05548283

Study to Evaluate Biological & Clinical Effects of Significantly Corrected CFTR Function in Infants & Young Children

RecruitingObservational study
Up to age 10 · All sexes · Updated Jul 8, 2026 · NCT04509050

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.