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Cystic Fibrosis clinical trials recruiting in the U.S.

64 studies for Cystic Fibrosis are recruiting participants at sites across the United States.

Cystic fibrosis (CF) is an inherited disease of the mucus and sweat glands. The symptoms and severity of CF can vary. Get the facts.

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Recently updated studies

Phase 2 Study to Assess the Safety and Efficacy of ANG003

RecruitingPhase 2
Ages 12 and older · All sexes · Updated Sep 28, 2026 · NCT07450547

Natural History of Bronchiectasis

RecruitingObservational studyHealthy volunteers welcome
Ages 5 to 100 · All sexes · Updated Sep 28, 2026 · NCT00943514

Dose Escalation Study Evaluating the Safety and Pharmacokinetics of VX-272 in Healthy Participants

RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 55 · All sexes · Updated Sep 23, 2026 · NCT07437105

Natural History of Noncirrhotic Portal Hypertension

RecruitingObservational study
Ages 12 to 100 · All sexes · Updated Sep 22, 2026 · NCT02417740

Dose Escalation Study Evaluating the Safety and Pharmacokinetics of VX-581 in Healthy Participants

RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 55 · All sexes · Updated Sep 21, 2026 · NCT07283770

ATUSA Ultrasound Diagnostic Imaging for Breast Lesions Evaluation (AUDIBLE) - iSono Health

RecruitingObservational study
Ages 18 to 94 · Women · Updated Sep 17, 2026 · NCT07505797

Genetics of Insulin and Incretins in Cystic Fibrosis

RecruitingObservational study
Ages 2 and older · All sexes · Updated Sep 16, 2026 · NCT01852448

Sinus Disease in Young Children With Cystic Fibrosis

RecruitingObservational study
Ages 2 to 8 · All sexes · Updated Sep 10, 2026 · NCT06191640

Role of Genetic Factors in the Development of Lung Disease

RecruitingObservational studyHealthy volunteers welcome
Ages 2 to 90 · All sexes · Updated Sep 10, 2026 · NCT00001532

Impact of Sinus Surgery on Individuals With Cystic Fibrosis

RecruitingObservational study
Ages 18 to 99 · All sexes · Updated Sep 10, 2026 · NCT04469439

Hormonal Responses to a Mixed Meal in People With Cystic Fibrosis

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 45 · All sexes · Updated Aug 25, 2026 · NCT06163482

Remote Sputum Collection in Cystic Fibrosis

RecruitingObservational study
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT06950892

Streamlined Treatment of Pulmonary Exacerbations in Pediatrics

Recruiting
Ages 3 to 18 · All sexes · Updated Aug 3, 2026 · NCT06654752

Continuous Glucose Monitoring and OGTT Screen for Cystic Fibrosis Related Diabetes in Cystic Fibrosis

RecruitingObservational study
Ages 18 and older · All sexes · Updated Jul 31, 2026 · NCT06560463

Bacteriophages for Adults With Cystic Fibrosis and Chronic Achromobacter Lung Infection

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Jul 15, 2026 · NCT07275905

Study to Evaluate Biological & Clinical Effects of Significantly Corrected CFTR Function in Infants & Young Children

RecruitingObservational study
Up to age 10 · All sexes · Updated Jul 8, 2026 · NCT04509050

Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study

RecruitingPhase 4
Ages 6 and older · All sexes · Updated Jul 8, 2026 · NCT05548283

4D-710 in Adult Patients With Cystic Fibrosis

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jul 6, 2026 · NCT05248230

TIDES 2.0: Prevalence and Longitudinal Course of Depression, Anxiety, and Behavior Problems in Children With Cystic Fibrosis Under 12 Years of Age

RecruitingObservational study
18 Months – 11 Years · All sexes · Updated Jul 6, 2026 · NCT07048574

Gastrointestinal Response of Pediatric Cystic Fibrosis Patients on Mediterranean Diet

Recruiting
Ages 3 to 18 · All sexes · Updated Jul 2, 2026 · NCT07223255

Quantitation and Spatial Registration of Airways Dysfunction With Dynamic 19F MRI in Cystic Fibrosis

RecruitingObservational study
Ages 18 to 99 · All sexes · Updated Jul 2, 2026 · NCT06057714

Study to Enable New Diagnostics for Pulmonary Microbes in People With CF

RecruitingObservational study
Ages 16 and older · All sexes · Updated Jul 2, 2026 · NCT07312734

Evaluation of Ventilation Defects Downstream of Mucus Plugs in Patients With Muco-Obstructive Lung Disease

RecruitingObservational study
Ages 18 to 65 · All sexes · Updated Jul 1, 2026 · NCT06985225

FEED-Cystic Fibrosis (FEED-CF)

RecruitingMentions payment for participants
Ages 18 and older · All sexes · Updated Jun 3, 2026 · NCT05766774

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.