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Emphysema clinical trials recruiting in the U.S.

18 studies for Emphysema are recruiting participants at sites across the United States.

Emphysema is a type of COPD. COPD makes it hard to breathe. The most common cause of Emphysema is smoking. Learn about symptoms and treatment.

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Recently updated studies

A Study of Brenipatide (LY3537031) in Adult Participants With Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD)

RecruitingPhase 2
Ages 40 to 75 ยท All sexes ยท Updated Nov 5, 2026 ยท NCT07759245

Xenon MRI to Evaluate Changes to Lung Function Following Bronchoscopic Treatment of Air Trapping in Emphysema

RecruitingEarly phase 1
Ages 40 to 84 ยท All sexes ยท Updated Oct 27, 2026 ยท NCT07896902

Collection of Airway, Blood and/or Urine Specimens From Subjects for Research Studies

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older ยท All sexes ยท Updated Oct 23, 2026 ยท NCT01776398

Bronchoscopic RElease of Air Trapped in Hyperinflated Emphysematous Lung - Study 3

Recruiting
Ages 40 to 84 ยท All sexes ยท Updated Oct 19, 2026 ยท NCT06891755

STRIVE Post-Market Registry Study

RecruitingObservational study
Ages 18 and older ยท All sexes ยท Updated Oct 16, 2026 ยท NCT04302272

Gene Therapy for Alpha 1- Antitrypsin Deficiency

RecruitingPhase 1
Ages 18 to 70 ยท All sexes ยท Updated Oct 16, 2026 ยท NCT06996756

A Multi Center Study Testing a New Implant for Adults With Severe Emphysema

Recruiting
Ages 22 and older ยท All sexes ยท Updated Oct 14, 2026 ยท NCT07119229

COPD Resources, Education, and Activity Designed for You Study

Recruiting
Ages 40 and older ยท All sexes ยท Updated Oct 8, 2026 ยท NCT07125053

Emphysema Research Registry and Biosample Repository

RecruitingObservational studyHealthy volunteers welcome
Ages 21 and older ยท All sexes ยท Updated Oct 6, 2026 ยท NCT00307281

An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients With Severe Emphysema

Recruiting
Ages 40 to 80 ยท All sexes ยท Updated Sep 17, 2026 ยท NCT06035120

Inter-lobar Fissure Completion in Patients With Failed Bronchoscopic Lung Volume Reduction

Recruiting
Ages 40 to 75 ยท All sexes ยท Updated Aug 28, 2026 ยท NCT05257681

PiMZ Longitudinal Cohort (PiMZ Logic)

RecruitingObservational study
Ages 18 and older ยท All sexes ยท Updated Jan 16, 2026 ยท NCT06505603

Lung and Bone Marrow Transplantation for Lung and Bone Marrow Failure

RecruitingPhase 1/2
Ages 18 to 60 ยท All sexes ยท Updated Jan 13, 2026 ยท NCT03500731

Implementation of a Sarcopenia Clinic to Diagnose and Treat Skeletal Muscle Loss Due to COPD

Recruiting
Ages 40 and older ยท All sexes ยท Updated Oct 30, 2025 ยท NCT07059637

Clinical Validation of Freenome Multiomics Blood Test for Lung Cancer Screening

RecruitingObservational study
Ages 50 and older ยท All sexes ยท Updated Aug 5, 2025 ยท NCT06122077

Site and Mechanism(s) of Expiratory Airflow Limitation in COPD, Emphysema and Asthma-COPD Overlap

RecruitingObservational studyHealthy volunteers welcome
Ages 30 and older ยท All sexes ยท Updated Oct 27, 2023 ยท NCT03263130

COPD Patient-Powered Research Network

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older ยท All sexes ยท Updated Mar 10, 2022 ยท NCT02803242

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.