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Flu clinical trials recruiting in the U.S.

47 studies for Flu are recruiting participants at sites across the United States.

The flu can cause serious illness in people over 65, babies, and people with certain chronic illnesses. The best way to prevent the flu is to get a vaccine.

Cities with the most studies

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Recently updated studies

A Study to Evaluate the Safety and Efficacy of MK-1406/CD388 for Prevention of Influenza (MK-1406-005/CD388.SQ.3.06)

RecruitingPhase 3
Ages 12 and older · All sexes · Updated Nov 13, 2026 · NCT07159763

A Study of Updated mRNA Seasonal Influenza Vaccines

RecruitingPhase 4Healthy volunteers welcome
Ages 65 and older · All sexes · Updated Nov 13, 2026 · NCT07884175

First-in-Human Study of VNT-101: Safety, Tolerability, and Pharmacokinetics

RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 59 · All sexes · Updated Nov 13, 2026 · NCT07169318

pH1N1 Blinded Challenge Study

RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 55 · All sexes · Updated Nov 13, 2026 · NCT07110532

BPL-1357 Against H1N1 Influenza Virus Challenge

RecruitingPhase 2Healthy volunteers welcome
Ages 18 to 55 · All sexes · Updated Nov 13, 2026 · NCT07215858

Screening for LID Clinical Studies Unit Healthy Volunteer Protocols

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 65 · All sexes · Updated Nov 12, 2026 · NCT01386424

Systems Investigation of Vaccine Responses in Aging and Frailty

RecruitingPhase 2Healthy volunteers welcome
Ages 21 and older · All sexes · Updated Nov 10, 2026 · NCT05291676

A Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1010 in Healthy Children

RecruitingPhase 1Healthy volunteers welcome
Ages 9 to 17 · All sexes · Updated Nov 5, 2026 · NCT07870330

Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia

RecruitingPhase 3
28 Days · All sexes · Updated Nov 4, 2026 · NCT02735707

A Trial to Evaluate the Effect of CD388/MK1406 on the Immunogenicity of Fluzone® HD Vaccine (CD388.SQ.1.08/MK-1406-007)

RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 49 · All sexes · Updated Nov 4, 2026 · NCT07300085

Age-Associated Differences in Germinal Center Responses to Influenza and Rabies Vaccination in Humans

RecruitingPhase 4
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT07914673

Comparative Immunogenicity of Respiratory Virus Vaccines (CIRV2) Study

RecruitingPhase 4Healthy volunteers welcome
Ages 18 to 79 · All sexes · Updated Nov 2, 2026 · NCT07287137

Clinical Outcomes and Pharmacotherapy Effectiveness in the VA Health Care System (COPE-VA)

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Nov 2, 2026 · NCT06160128

Impact of Egg-Based and Cell-Based Vaccine Platforms on Immune Responses to Repeated Influenza Vaccination

RecruitingPhase 4Healthy volunteers welcomeMentions payment for participants
Ages 18 and older · All sexes · Updated Nov 2, 2026 · NCT07910266

Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 30, 2026 · NCT05624450

High vs.Standard Dose Influenza Vaccine in Pediatric Solid Organ Transplant (SOT) Recipients

RecruitingPhase 2
Ages 3 to 17 · All sexes · Updated Oct 28, 2026 · NCT05947071

Light-based Immunomodulation for Guarding Against Human Respiratory Tract Infections

RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Oct 26, 2026 · NCT07610967

High vs. Standard Dose Influenza Vaccines in Lung Transplant (Repeater)

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 21, 2026 · NCT07192458

A Study to Evaluate the Immune Response and Safety of a Vaccine Against Influenza in Adults 18-64 Years of Age

RecruitingPhase 3Healthy volunteers welcome
Ages 18 to 64 · All sexes · Updated Oct 9, 2026 · NCT07851246

Longitudinal Deep Phenotyping of Central Mechanisms in Dysosmia: A Pilot Study Using Electrobulbogram (EBG), Functional MRI (fMRI), and Diffusion-Weighted Imaging (DWI)

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 99 · All sexes · Updated Oct 9, 2026 · NCT07149428

Optimizing Lymphatic Pumping for Influenza Vaccine Responses in Vulnerable Populations

RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07786467

A Study on the Efficacy of a Vaccine Against Influenza in Adults ≥65 Years of Age

RecruitingPhase 3Healthy volunteers welcome
Ages 65 and older · All sexes · Updated Sep 18, 2026 · NCT07805707

Study to Assess Safety and Immunogenicity of an Egg-based H5N8 Influenza Vaccine at Multiple Dose Levels Adjuvanted With Matrix-M in Healthy Participants 18 Years of Age and Above.

RecruitingPhase 1/2Healthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT07779408

Observational Digital Biomarker Discovery in Respiratory Virus Challenge Studies

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 65 · All sexes · Updated Sep 9, 2026 · NCT04772170

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.