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Flu clinical trials recruiting in the U.S.

39 studies for Flu are recruiting participants at sites across the United States.

The flu can cause serious illness in people over 65, babies, and people with certain chronic illnesses. The best way to prevent the flu is to get a vaccine.

Cities with the most studies

By state

Recently updated studies

BPL-1357 Against H1N1 Influenza Virus Challenge

RecruitingPhase 2Healthy volunteers welcome
Ages 18 to 55 · All sexes · Updated Sep 28, 2026 · NCT07215858

pH1N1 Blinded Challenge Study

RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 55 · All sexes · Updated Sep 25, 2026 · NCT07110532

High vs.Standard Dose Influenza Vaccine in Pediatric Solid Organ Transplant (SOT) Recipients

RecruitingPhase 2
Ages 3 to 17 · All sexes · Updated Sep 24, 2026 · NCT05947071

Optimizing Lymphatic Pumping for Influenza Vaccine Responses in Vulnerable Populations

RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07786467

Screening for LID Clinical Studies Unit Healthy Volunteer Protocols

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 65 · All sexes · Updated Sep 22, 2026 · NCT01386424

A Study on the Efficacy of a Vaccine Against Influenza in Adults ≥65 Years of Age

RecruitingPhase 3Healthy volunteers welcome
Ages 65 and older · All sexes · Updated Sep 18, 2026 · NCT07805707

Study to Assess Safety and Immunogenicity of an Egg-based H5N8 Influenza Vaccine at Multiple Dose Levels Adjuvanted With Matrix-M in Healthy Participants 18 Years of Age and Above.

RecruitingPhase 1/2Healthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT07779408

Observational Digital Biomarker Discovery in Respiratory Virus Challenge Studies

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 65 · All sexes · Updated Sep 9, 2026 · NCT04772170

Clinical Outcomes and Pharmacotherapy Effectiveness in the VA Health Care System (COPE-VA)

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT06160128

Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Aug 28, 2026 · NCT05624450

Dime La VerDAD: Verify, Debunk, and Disseminate

RecruitingHealthy volunteers welcome
Ages 18 to 99 · All sexes · Updated Aug 26, 2026 · NCT06417762

Respiratory Virus Sampling and Repository

RecruitingObservational study
Ages 3 and older · All sexes · Updated Aug 17, 2026 · NCT05266222

Fluad vs. Fluzone High-Dose Vaccine Effectiveness Among Adults ≥65 Years

RecruitingObservational studyHealthy volunteers welcome
Ages 65 and older · All sexes · Updated Aug 5, 2026 · NCT06029933

Baloxavir and Oseltamivir for the Treatment of Severe Influenza Infection in Immunocompromised Patients

RecruitingPhase 2
Ages 12 and older · All sexes · Updated Jul 16, 2026 · NCT04712539

The Effects of Endotracheal Suctioning on Pain and Serum Markers

Recruiting
Ages 18 and older · All sexes · Updated Jul 10, 2026 · NCT06692400

A Study on the Safety and Immune Response of Investigational mRNA Seasonal Flu/COVID-19 Combination Vaccine in Adults

RecruitingPhase 1
Ages 65 to 85 · All sexes · Updated Jun 30, 2026 · NCT07464314

Flu Infection at UPHS

RecruitingObservational study
Ages 18 and older · All sexes · Updated Jun 3, 2026 · NCT06807840

First-in-Human Study of VNT-101: Safety, Tolerability, and Pharmacokinetics

RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 59 · All sexes · Updated May 11, 2026 · NCT07169318

A Study to Learn About mRNA Vaccines Against Influenza in Adults

RecruitingPhase 2Healthy volunteers welcome
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT07431853

Woodsmoke Exposure, Influenza Infection, and Nasal Immunity

RecruitingPhase 4Healthy volunteers welcome
Ages 18 to 49 · All sexes · Updated Apr 30, 2026 · NCT06841913

H5N1 Milk Detection Study

RecruitingHealthy volunteers welcome
Ages 18 to 64 · All sexes · Updated Apr 15, 2026 · NCT06850298

The INFLUENTIAL Trial- Evaluation of National Inpatient Influenza Vaccination Program

RecruitingHealthy volunteers welcome
6 Months – 99 Years · All sexes · Updated Apr 8, 2026 · NCT05832307

MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies

RecruitingPhase 2
Up to age 60 · All sexes · Updated Apr 6, 2026 · NCT05735717

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.