Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia

The eligibility criteria for the Platform are applied at multiple levels. One level is that there are inclusion and exclusion criteria that determine eligibility for randomization within the Platform. Another level is that, once eligible for inclusion within the Platform, additional criteria (typically exclusion criteria) are applied that are specific to each domain. Finally, intervention-level eligibility criteria may be applied for interventions within a domain. A patient is eligible for inclusion within a domain when:

* All Platform inclusion criteria are met
* None of the Platform exclusion criteria are met
* Domain-specific eligibility criteria are met
* The patient is eligible for at least two interventions within a domain

As such, the key "inclusion criteria" for being eligible for a domain are that the patient is eligible for the Platform.

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PLATFORM INCLUSION CRITERIA:

1. Hospitalised patient
2. Acute respiratory tract infection
3. Aged 28 days or older

PLATFORM EXCLUSION CRITERIA:

1. Death is deemed to be imminent and inevitable during the next 24 hours AND one or more of the patient, substitute decision maker or attending physician are not committed to full active treatment
2. Patient is expected to be discharged from hospital within the next 24 hours
3. Previous participation in this REMAP within the last 90 days

DOMAIN-SPECIFIC ELIGIBILITY CRITERIA:

Each domain may have additional eligibility criteria. Refer to the study website for more information (www.remapcap.org).