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Esophageal Cancer Risk Registry
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Known or suspected esophageal or gastroesophageal junction malignancy * Known Barrett's metaplasia * Clinical management of symptomatic gastroesophageal reflux disease (GERD) * Achalasia * Hiatal hernia Exclusion Criteria: * Elevated pre-operative bloodwork will not have the additional biopsies taken. * Platelet count less than 150,000, partial thromboplastin time (PTT) of 50 or above, and/or International Normalized Ratio (INR) of 1.8 or above will not have the additional biopsies taken.
About the study
The purpose of this study is to identify markers in the blood and tissue that could indicate risk factors for the development and progression of esophagus cancer. This research aims to collect medical history, blood, and tissue samples from patients who present with an esophageal disorder. Identifying genetic and behavioral risk factors involved in the development of esophageal cancer might allow for early detection and prevention. Survival and an opportunity for a cure with esophageal cancer will depend greatly on the stage of diagnosis. Tumors can develop changes in their genetic (hereditary) make-up, and these changes can sometimes be seen in normal tissues before the development of cancer. These genetic (hereditary) changes can serve as tumor markers and can be detected using methods that study changes in genetic material like DNA and RNA. The analysis of proteins can provide additional information. By identifying changes in these molecules that are different or altered in cancer, the investigators can use methods and tests for the detection of these changes.
What is being tested
- Survey of client health, personal habits, family history (procedure)
- Blood specimen for non-DNA and DNA parts (procedure)
- Biopsy of esophageal/stomach tissue, lymph nodes, tumor (procedure)
- Biopsies, oral (saliva) and/or secretions, washings or mucosal scrapings/brushing from routine clinical surveillance endoscopies (procedure)
Sponsor: University of Pittsburgh · Participants: 7,000 · Started: 1999-06
Contact the study team
- Julie A Ward, BSN · Phone: 412-647-8583
Official record on ClinicalTrials.gov — NCT00260585
Locations in the U.S.
| Pennsylvania | Department of Cardiothoracic Surgery, Pittsburgh |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.