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Heart Failure clinical trials in Missouri
40 studies for Heart Failure are looking for participants at sites in Missouri.
Cities in Missouri
A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF
- Research Site, Bridgeton
- Research Site, Kansas City
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07761117Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
- Saint Luke's Hospital of Kansas City, Kansas City
- Washington University Center for Advanced Medicine, St Louis
RecruitingPhase 3
Ages 18 to 85 · All sexes · Updated Sep 24, 2026 · NCT06736574Barostim-Enabled NEurohormonal Intervention For Improving Treatment of Heart Failure
- Saint Luke's Hospital of Kansas City, Kansas City
Recruiting
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07232030A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
- Kansas City VA Medical Center, Kansas City
- St. Louis Heart and Vascular, P.C., St Louis
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06935370A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
- Kansas City VA Medical Center, Kansas City
- North Kansas City Hospital, North Kansas City
- St. Louis Heart and Vascular, P.C., St Louis
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06424288A Study of LY3971297 in Participants With Heart Failure
- Washington University, St Louis
RecruitingPhase 1
Ages 18 to 65 · All sexes · Updated Sep 22, 2026 · NCT07547540Alleviant ALLAY-HFrEF Study
- Washington University - St Louis, St Louis
Recruiting
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT06812533Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
- Saint Luke's Hospital of Kansas City, Kansas City
RecruitingPhase 3
Ages 18 to 99 · All sexes · Updated Sep 16, 2026 · NCT07037459Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin
- Research Site, Columbia
- Research Site, Kansas City
- Research Site, Kansas City
- and 1 more
RecruitingPhase 3
Ages 40 and older · All sexes · Updated Sep 15, 2026 · NCT06677060Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function
- Research Site, Columbia
- Research Site, Kansas City
- Research Site, Kansas City
RecruitingPhase 3
Ages 18 to 130 · All sexes · Updated Sep 11, 2026 · NCT06307652A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients
- Kansas City, MO Investigative Site 10002, Kansas City
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06008197A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients With Heart Failure (CONFIRMATION-HF)
- CON-10002 Kansas City, MO Investigative Site, Kansas City
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06024746The WiSE®-UP Study (The WiSE System Utilization & Performance Study)
- St. Luke's Hospital of Kansas City, Kansas City
RecruitingObservational study
Ages 22 and older · All sexes · Updated Sep 10, 2026 · NCT07098858Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure
- WashU Medicine, St Louis
Recruiting
Ages 18 to 100 · All sexes · Updated Sep 9, 2026 · NCT06310031A Study of EDG-15400 in Adults With Heart Failure With Preserved Ejection Fraction (EQUINOX-HFpEF)
- Local Institution - 145, Kansas City
- Local Institution - 109, St Louis
RecruitingPhase 2
Ages 30 to 84 · All sexes · Updated Aug 31, 2026 · NCT07795814Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)
- Washington University-Pediatric Cardiology/ St. Louis Children's Hospital ( Site 0006), St Louis
RecruitingPhase 2/3
29 Days – 17 Years · All sexes · Updated Aug 28, 2026 · NCT05714085AMBER-HFpEF: Assessment of CK-4021586 in a Multi-Center, Blinded Evaluation of Safety and Tolerability Results in HFpEF
- Washington University Center for Advanced Medicine, St Louis
RecruitingPhase 2
Ages 40 to 85 · All sexes · Updated Aug 27, 2026 · NCT06793371Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products
- Columbia
- Kansas City
- St Louis
RecruitingObservational study
All ages · All sexes · Updated Aug 20, 2026 · NCT00271180LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2
- Tenax Investigational Site, Kansas City
- Tenax Investigational Site, St Louis
RecruitingPhase 3
Ages 18 to 85 · All sexes · Updated Aug 19, 2026 · NCT07288398A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)
- St. Luke's Mid-America Heart Institute, Kansas City
- Washington University, St Louis
RecruitingObservational study
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT05489705A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
- Clinical Research Consultants, JCCT Co, Kansas City
- Washington University, St Louis
- Amicis Centers of Clinical Research, St Louis
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07567001Alleviant ALLAY-HF Study
- Washington University - St Louis, St Louis
Recruiting
Ages 40 and older · All sexes · Updated Aug 14, 2026 · NCT05685303Assessment of CCM in HF With Higher Ejection Fraction
- St. Louis Heart and Vascular, Bridgeton
- St. Lukes Hospital Kansas City (Mid America Heart Institute), Kansas City
Recruiting
Ages 18 and older · All sexes · Updated Aug 6, 2026 · NCT05064709A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy
- Washington University School of Medicine, St Louis
RecruitingPhase 2
Ages 40 to 84 · All sexes · Updated Aug 5, 2026 · NCT06979362ELEVATE-HFpEF Clinical Study
- Saint Lukes Mid America Heart Institute, Kansas City
Recruiting
Ages 40 and older · All sexes · Updated Aug 3, 2026 · NCT06678841Study to Evaluate Safety, Tolerability and Efficacy of Inclisiran in Children With Homozygous Familial Hypercholesterolemia
- Washington Univ School Of Medicine, St Louis
RecruitingPhase 3
Ages 2 to 11 · All sexes · Updated Jul 24, 2026 · NCT06597006A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients With Heart Failure Who Are Intolerant or Not Eligible for Treatment With Steroidal Mineralocorticoid Receptor Antagonists
- FIN-10002 Kansas City, MO Investigational Site, Kansas City
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Jul 10, 2026 · NCT06033950PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III
- St. Lukes/ Mid-American Heart Institute, Kansas City
Recruiting
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT05934487A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction
- Children's Mercy Hospital Kansas City - Cardiology, Kansas City
- Washington University - St. Louis Children's Hospital - Cardiology, St Louis
RecruitingPhase 3
Up to age 18 · All sexes · Updated Jun 29, 2026 · NCT07192952A Study to Learn More About How Well Finerenone Works, How Safe it is, and How it Moves Into, Through, and Out of the Body Compared to Placebo When Taken With Standard Treatment in Children With Heart Failure and Left Ventricular Systolic Dysfunction
- Children's Mercy Hospital Kansas City - Cardiology, Kansas City
- Washington University - St. Louis Children's Hospital - Cardiology, St Louis
RecruitingPhase 3
6 Months – 17 Years · All sexes · Updated Jun 15, 2026 · NCT07188805Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
- St. Luke's Hospital, Kansas City
Recruiting
Ages 18 and older · All sexes · Updated Jun 10, 2026 · NCT06526195Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)
- University of Missouri-Columbia, Columbia
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 100 · All sexes · Updated May 7, 2026 · NCT07083557The Inorganic Nitrate and eXercise Performance in Heart Failure (iNIX-HF)
- Washington University School of Medicine, St Louis
RecruitingPhase 2
Ages 19 to 79 · All sexes · Updated May 6, 2026 · NCT05562167CCM OPEN HF Registry
- Saint Luke's Hospital Mid America Heart Institute, Kansas City
- Saint Luke's Hospital of Kansas City, Kansas City
RecruitingObservational study
Ages 18 and older · All sexes · Updated Apr 23, 2026 · NCT07112924The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR
- St. Louis Heart and Vascular, St Louis
Recruiting
Ages 18 and older · All sexes · Updated Apr 13, 2026 · NCT03142152Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease
- Washington University, St Louis
RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Mar 24, 2026 · NCT06217302XVIVO Heart Box (XHB) With Supplemented XVIVO Heart Solution (SXHS) Continued Access Protocol (CAP)
- Washington University - Barnes Jewish Health Hospital, St Louis
Recruiting
Ages 18 and older · All sexes · Updated Mar 18, 2026 · NCT06895070Comparative Effectiveness of Carvedilol Versus Metoprolol Succinate in Heart Failure Patients With an Implantable Cardioverter Defibrillator
- University of Mossouri, Columbia
RecruitingPhase 4
Ages 18 and older · All sexes · Updated Sep 18, 2025 · NCT06964464HF2 Registry - Hemodynamic Frontiers in Heart Failure Registry
- Saint Luke's Health System, Kansas City
RecruitingObservational study
Ages 18 to 100 · All sexes · Updated May 22, 2024 · NCT06425848Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Reduced Ejection Fraction
- Washington University in Saint Louis, St Louis
RecruitingPhase 1/2
Ages 18 to 80 · All sexes · Updated Mar 26, 2024 · NCT04703842From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.