🔎 Trials Near Me

Home › Heart Failure › Missouri › St. Louis

Heart Failure clinical trials in St. Louis, MO

26 studies for Heart Failure are looking for participants at sites in and around St. Louis (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF

RecruitingPhase 3
  • Research Site, Bridgeton · 15 mi away
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07761117

Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

RecruitingPhase 3
  • Washington University Center for Advanced Medicine, St Louis
Ages 18 to 85 · All sexes · Updated Sep 24, 2026 · NCT06736574

A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure

RecruitingPhase 3
  • St. Louis Heart and Vascular, P.C., St Louis
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06424288

A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart

RecruitingPhase 3
  • St. Louis Heart and Vascular, P.C., St Louis
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06935370

A Study of LY3971297 in Participants With Heart Failure

RecruitingPhase 1
  • Washington University, St Louis
Ages 18 to 65 · All sexes · Updated Sep 22, 2026 · NCT07547540

Alleviant ALLAY-HFrEF Study

Recruiting
  • Washington University - St Louis, St Louis
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT06812533

Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

RecruitingPhase 3
  • Research Site, St Louis
Ages 40 and older · All sexes · Updated Sep 15, 2026 · NCT06677060

Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure

Recruiting
  • WashU Medicine, St Louis
Ages 18 to 100 · All sexes · Updated Sep 9, 2026 · NCT06310031

A Study of EDG-15400 in Adults With Heart Failure With Preserved Ejection Fraction (EQUINOX-HFpEF)

RecruitingPhase 2
  • Local Institution - 109, St Louis
Ages 30 to 84 · All sexes · Updated Aug 31, 2026 · NCT07795814

Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)

RecruitingPhase 2/3
  • Washington University-Pediatric Cardiology/ St. Louis Children's Hospital ( Site 0006), St Louis
29 Days – 17 Years · All sexes · Updated Aug 28, 2026 · NCT05714085

AMBER-HFpEF: Assessment of CK-4021586 in a Multi-Center, Blinded Evaluation of Safety and Tolerability Results in HFpEF

RecruitingPhase 2
  • Washington University Center for Advanced Medicine, St Louis
Ages 40 to 85 · All sexes · Updated Aug 27, 2026 · NCT06793371

Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products

RecruitingObservational study
  • St Louis, St Louis
All ages · All sexes · Updated Aug 20, 2026 · NCT00271180

LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2

RecruitingPhase 3
  • Tenax Investigational Site, St Louis
Ages 18 to 85 · All sexes · Updated Aug 19, 2026 · NCT07288398

A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity

RecruitingPhase 3
  • Washington University, St Louis
  • Amicis Centers of Clinical Research, St Louis
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07567001

Alleviant ALLAY-HF Study

Recruiting
  • Washington University - St Louis, St Louis
Ages 40 and older · All sexes · Updated Aug 14, 2026 · NCT05685303

Assessment of CCM in HF With Higher Ejection Fraction

Recruiting
  • St. Louis Heart and Vascular, Bridgeton · 15 mi away
Ages 18 and older · All sexes · Updated Aug 6, 2026 · NCT05064709

Study to Evaluate Safety, Tolerability and Efficacy of Inclisiran in Children With Homozygous Familial Hypercholesterolemia

RecruitingPhase 3
  • Washington Univ School Of Medicine, St Louis
Ages 2 to 11 · All sexes · Updated Jul 24, 2026 · NCT06597006

A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction

RecruitingPhase 3
  • Washington University - St. Louis Children's Hospital - Cardiology, St Louis
Up to age 18 · All sexes · Updated Jun 29, 2026 · NCT07192952

The Inorganic Nitrate and eXercise Performance in Heart Failure (iNIX-HF)

RecruitingPhase 2
  • Washington University School of Medicine, St Louis
Ages 19 to 79 · All sexes · Updated May 6, 2026 · NCT05562167

The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR

Recruiting
  • St. Louis Heart and Vascular, St Louis
Ages 18 and older · All sexes · Updated Apr 13, 2026 · NCT03142152

Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease

RecruitingPhase 3
  • Washington University, St Louis
Ages 18 to 75 · All sexes · Updated Mar 24, 2026 · NCT06217302

XVIVO Heart Box (XHB) With Supplemented XVIVO Heart Solution (SXHS) Continued Access Protocol (CAP)

Recruiting
  • Washington University - Barnes Jewish Health Hospital, St Louis
Ages 18 and older · All sexes · Updated Mar 18, 2026 · NCT06895070

Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Reduced Ejection Fraction

RecruitingPhase 1/2
  • Washington University in Saint Louis, St Louis
Ages 18 to 80 · All sexes · Updated Mar 26, 2024 · NCT04703842

About Heart Failure

Heart failure, or congestive heart failure (CHF), means the heart can't pump enough blood. Learn about the signs, symptoms, and causes.

More about Heart Failure on MedlinePlus

Heart Failure trials in other cities

Other studies in St. Louis

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.