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Heart Valve Diseases clinical trials recruiting in the U.S.
31 studies for Heart Valve Diseases are recruiting participants at sites across the United States.
Heart valve disease happens when one or more of your heart valves do not open or close correctly. This can affect your blood flow and strain your heart.
Cities with the most studies
- Cleveland, OH10 studies
- New York City, NY10 studies
- Phoenix, AZ6 studies
- Cincinnati, OH6 studies
- Los Angeles, CA5 studies
- Philadelphia, PA5 studies
- Chicago, IL5 studies
- Wichita, KS5 studies
- Minneapolis, MN5 studies
- Pittsburgh, PA4 studies
- Boston, MA4 studies
- Atlanta, GA4 studies
- San Francisco, CA4 studies
- Houston, TX4 studies
- Portland, OR4 studies
- St. Louis, MO3 studies
- Seattle, WA3 studies
- Nashville, TN3 studies
- Thousand Oaks, CA3 studies
- Columbus, OH3 studies
- Harrisburg, PA3 studies
- Plano, TX3 studies
- Newark, NJ3 studies
- Ann Arbor, MI3 studies
- New Orleans, LA3 studies
By state
- Arizona6 studies
- California9 studies
- Connecticut3 studies
- Florida3 studies
- Georgia5 studies
- Illinois7 studies
- Indiana3 studies
- Kansas6 studies
- Louisiana3 studies
- Maryland3 studies
- Massachusetts4 studies
- Michigan5 studies
- Minnesota7 studies
- Missouri3 studies
- New Jersey6 studies
- New York10 studies
- North Carolina3 studies
- Ohio14 studies
- Oklahoma3 studies
- Oregon4 studies
- Pennsylvania7 studies
- Tennessee4 studies
- Texas6 studies
- Virginia4 studies
- Washington3 studies
- Wisconsin3 studies
Recently updated studies
Abbott Structural Heart Device Registry
RecruitingObservational study
All ages · All sexes · Updated Nov 13, 2026 · NCT06590467TransCatheter Replacement Of the Mitral Valve With the Novel Cephea Mitral Valve System
Recruiting
Ages 18 and older · All sexes · Updated Nov 13, 2026 · NCT07798726Transcatheter Tricuspid Valve Replacement With the Medtronic Intrepid™ Transcatheter Tricuspid Valve Replacement (TTVR) System in Severe Tricuspid Regurgitation
Recruiting
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT07321899VDyne TriNova Transcatheter Tricuspid Valve Replacement Study to Evaluate Safety and Clinical Efficacy in Patients With Symptomatic Severe Tricuspid Valve Regurgitation (TRIVITA Pivotal Trial)
Recruiting
Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT07516444Tricuspid Regurgitation Treatment With LAPLACE Transcatheter Tricuspid Valve Replacement System
Recruiting
Ages 18 to 90 · All sexes · Updated Nov 2, 2026 · NCT07687485Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.
Recruiting
Ages 18 and older · All sexes · Updated Oct 30, 2026 · NCT03242642The TRICURE EFS Study
Recruiting
Ages 18 and older · All sexes · Updated Oct 29, 2026 · NCT06506942TRIFORMIS RESILIA Real-world Study Assessing Safety and Performance (TRIBLAZE Study)
RecruitingObservational study
Ages 18 and older · All sexes · Updated Oct 21, 2026 · NCT07684313EFS of the DUO System for Tricuspid Regurgitation
Recruiting
Ages 18 and older · All sexes · Updated Oct 21, 2026 · NCT05913908Balloon vs. Self Expanding Transcatheter Valve for Degenerated Bioprosthesis
Recruiting
Ages 18 and older · All sexes · Updated Oct 13, 2026 · NCT04843072Technical and Translational Development of Cardiovascular Magnetic Resonance (CMR) Imaging
RecruitingObservational studyHealthy volunteers welcome
Ages 7 to 100 · All sexes · Updated Oct 5, 2026 · NCT03581318Medtronic Cardiac Surgery PMCF Registry
RecruitingObservational study
All ages · All sexes · Updated Sep 25, 2026 · NCT04073420Global Multicenter Registry on Transcatheter TRIcuspid Valve RePLACEment
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT06033274Home-Based Cardiac Rehabilitation Using a Novel Mobile Health Exercise Regimen Following Transcatheter Heart Valve Interventions
Recruiting
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT06077201Paired-Ring Mitral Annuloplasty Ring Sizing Device
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT06965725Longitudinal Validation of CIRC Technologies
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Jul 31, 2026 · NCT07081711A Study Of Clinical Implications Of Pulmonary Vascular Disease In Valvular Heart Disease
RecruitingObservational study
Ages 18 and older · All sexes · Updated Jun 18, 2026 · NCT07483203AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Jun 1, 2026 · NCT06699056Development of CIRC Technologies
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated May 8, 2026 · NCT05654272DeBakey Cardiovascular Magnetic Resonance Study
RecruitingObservational studyHealthy volunteers welcome
All ages · All sexes · Updated Apr 20, 2026 · NCT04281823DELINEATE-Prospective
RecruitingObservational study
Ages 18 and older · All sexes · Updated Apr 16, 2026 · NCT07197736Observational Study of Patients Undergoing Diagnostic Right Heart Catheterization
RecruitingObservational study
Ages 18 and older · All sexes · Updated Apr 13, 2026 · NCT07224906The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR
Recruiting
Ages 18 and older · All sexes · Updated Apr 13, 2026 · NCT03142152PPG to Predict Ejection Fraction and Other Echographic Data in the General Population
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 120 · All sexes · Updated Mar 5, 2026 · NCT04843371Mosaic Mitral Valve: Long-Term Outcomes in Patients Under 65
RecruitingObservational study
Ages 18 to 65 · All sexes · Updated Feb 20, 2026 · NCT06917586From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.