Home › Cardiovascular Disease › NCT07081711
Longitudinal Validation of CIRC Technologies
Who can join
Ages 18 and older · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Age ≥ 18 years of age * Provision of written informed consent Exclusion Criteria: * Vulnerable populations will be excluded from this study including Prisoners * Other contraindications to CMR imaging to be determined by standard MRI protocols * Decisionally impaired (e.g., dementia or cognitive disability)
About the study
Cardiovascular disease is the leading cause of death worldwide. Advanced cardiovascular imaging using Magnetic Resonance Imaging (MRI) has proven to be effective in providing gold standard myocardial tissue characterization. Moreover, the intrinsic advantage of MRI's lack of exposure to ionizing radiation is particularly beneficial. At the same time, blood work can be very useful in early detection of certain cardiomyopathy, such as amyloid. However, there is a lack of agreement of on which markers are the most sensitive. This multi-study will allow the unique opportunity to form a more comprehensive understanding for various cardiovascular diseases.
The study team has developed novel cardiac MRI techniques that leverages endogenous tissue properties to reveal a milieu of deep tissue phenotypes including myocardial inflammation, fibrosis, metabolism, and microstructural defects. Among these phenotypes, myocardial microstructure has proven to be most sensitive to early myocardial tissue damage and is predictive of myocardial regeneration. In this study, the investigators aim to further study the importance of cardiac microstructure revealed by MRI in patient and healthy population and compare this novel technology with conventional clinical biomarkers.
Sponsor: The Cleveland Clinic · Participants: 1,000 · Started: May 6, 2026
Contact the study team
- Research Coordinator Research Coordinator · Phone: 216-445-6515
Official record on ClinicalTrials.gov — NCT07081711
Locations in the U.S.
| Ohio | Cleveland Clinic, Cleveland |
Conditions
- Cardiovascular Disease
- Heart Failure
- Myocardial Ischemia
- Heart Valve Diseases
- Congenital Heart Defects
- Atrial Fibrillation
- Ventricular Fibrillation
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.