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Lung Cancer clinical trials in Lexington, KY

18 studies for Lung Cancer are looking for participants at sites in and around Lexington (within about 30 miles). Open a study to see who can join and how to contact the study team.

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

RecruitingPhase 3
  • Baptist Health Lexington, Lexington
  • Baptist Health Hamburg, Lexington
  • University of Kentucky/Markey Cancer Center, Lexington
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT04267848

Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial

RecruitingPhase 3
  • University of Kentucky/Markey Cancer Center, Lexington
Ages 70 and older · All sexes · Updated Sep 30, 2026 · NCT06096844

Substudy 01I: A Study of Investigational Agents in Participants With Previously Treated Stage IV Squamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01I/KEYMAKER-U01I)

RecruitingPhase 2
  • University of Kentucky Chandler Medical Center ( Site 0019), Lexington
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT06780098

A Study to Compare the Combination of Navlimetostat (BMS-986504) With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP Deletion

RecruitingPhase 2/3
  • Baptist Health Lexington, Lexington
  • University of Kentucky Chandler Medical Center, Lexington
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07063745

Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Other Investigational Agents for Lung Cancer

RecruitingPhase 2/3
  • Baptist Health Lexington, Lexington
  • University of Kentucky Chandler Medical Center (UKCMC) - Markey Cancer Center (Lucille P. Markey Cancer Center), Lexington
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06712316

Testing the Combination of an Anti-cancer Drug, Iadademstat, With Other Anti-cancer Drugs (Atezolizumab or Durvalumab) at Improving Outcomes for Small Cell Lung Cancer

RecruitingPhase 1/2
  • University of Kentucky/Markey Cancer Center, Lexington
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT06287775

A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

RecruitingPhase 3
  • CHI Saint Joseph Cancer Center - East, Lexington
  • University of Kentucky Chandler Medical Center, Lexington
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT06119581

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • CommonSpirit Saint Joseph Hospital - Lexington, Lexington
  • Saint Joseph Radiation Oncology Resource Center, Lexington
  • CommonSpirit Saint Joseph Medical Center - East Lexington, Lexington
Ages 40 to 75 · All sexes · Updated Sep 2, 2026 · NCT05334069

A Study of Pembrolizumab With or Without Chemotherapy in Combination With Additional Treatments for Advanced Non-Small Cell Lung Cancer (NSCLC) (MK-3475-01G/KEYMAKER U01)

RecruitingPhase 2
  • University of Kentucky ( Site 0019), Lexington
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT06731907

EXoPERT EMERALD Clinical Study

RecruitingObservational studyHealthy volunteers welcome
  • Lexington VA Healthcare System, Lexington
Ages 45 and older · All sexes · Updated Jul 1, 2026 · NCT07186296

Comparing Combinations of Targeted Drugs for Advanced Non-Small Cell Lung Cancer That Has EGFR and MET Gene Changes (A Lung-MAP Treatment Trial)

RecruitingPhase 2
  • University of Kentucky/Markey Cancer Center, Lexington
Ages 18 and older · All sexes · Updated Jun 3, 2026 · NCT05642572

Pathways, a Hope Intervention to Support Personal Goal Pursuit, Mental Health, and Quality of Life During Advanced Lung Cancer Treatment

Recruiting
  • University of Kentucky, Lexington
Ages 18 and older · All sexes · Updated May 8, 2026 · NCT06047301

Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)

RecruitingPhase 2
  • University of Kentucky/Markey Cancer Center, Lexington
18 Minutes · All sexes · Updated May 5, 2026 · NCT06031688

Precision Lung Cancer Survivorship Care Intervention

Recruiting
  • Markey Cancer Center, Lexington
Ages 18 and older · All sexes · Updated Feb 23, 2026 · NCT05857995

A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

RecruitingPhase 1
  • University of Kentucky Markey Cancer Center, Lexington
Ages 18 and older · All sexes · Updated Feb 13, 2026 · NCT06778863

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

RecruitingObservational studyHealthy volunteers welcome
  • Baptist Lexington, Lexington
Ages 40 and older · All sexes · Updated Jan 20, 2026 · NCT05366881

Clinical Utility of Management of Patients With Pulmonary Nodules Using the Percepta Nasal Swab Classifier

RecruitingObservational study
  • Lexington VA Health Care System, Lexington
Ages 29 to 85 · All sexes · Updated Nov 13, 2024 · NCT06426628

About Lung Cancer

Lung cancer forms in tissues of the lung, usually in the cells that line the air passages. It is the leading cause of cancer death in both men and women.

More about Lung Cancer on MedlinePlus

Lung Cancer trials in other cities

Other studies in Lexington

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.