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Prostate Cancer clinical trials in Lexington, KY

14 studies for Prostate Cancer are looking for participants at sites in and around Lexington (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • CommonSpirit Saint Joseph Hospital - Lexington, Lexington
  • Saint Joseph Radiation Oncology Resource Center, Lexington
  • CommonSpirit Saint Joseph Medical Center - East Lexington, Lexington
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069

Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

RecruitingPhase 2
  • University of Kentucky/Markey Cancer Center, Lexington
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT03866382

A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)

RecruitingPhase 3
  • University of Kentucky Chandler Medical Center ( Site 0048), Lexington
Ages 18 and older · Men · Updated Sep 17, 2026 · NCT06925737

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

RecruitingPhase 3
  • Saint Joseph Hospital, Lexington
  • Saint Joseph Radiation Oncology Resource Center, Lexington
  • Saint Joseph Hospital East, Lexington
Ages 18 and older · Men · Updated Sep 10, 2026 · NCT05946213

Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging

RecruitingPhase 3
  • CommonSpirit Saint Joseph Hospital - Lexington, Lexington
  • Saint Joseph Radiation Oncology Resource Center, Lexington
  • CommonSpirit Saint Joseph Medical Center - East Lexington, Lexington
Ages 18 and older · Men · Updated Aug 19, 2026 · NCT04423211

Comparing Acupuncture vs. Sham Acupuncture for the Management of Hot Flashes in Prostate Cancer Patients Receiving Hormone Therapy

Recruiting
  • University of Kentucky, Lexington
Ages 18 to 99 · All sexes · Updated Aug 18, 2026 · NCT07594002

Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response

RecruitingPhase 3
  • CommonSpirit Saint Joseph Hospital - Lexington, Lexington
  • Saint Joseph Radiation Oncology Resource Center, Lexington
  • CommonSpirit Saint Joseph Medical Center - East Lexington, Lexington
  • and 1 more
Ages 18 and older · Men · Updated Jul 14, 2026 · NCT06592924

Testing the Safety and Effectiveness of Radiation-based Treatment (Lutetium Lu 177 Dotatate) for Metastatic Prostate Cancer That Has Neuroendocrine Cells

RecruitingPhase 2
  • University of Kentucky/Markey Cancer Center, Lexington
Ages 18 and older · Men · Updated Jul 14, 2026 · NCT05691465

Pembro With Radiation With or Without Olaparib

RecruitingPhase 2
  • University of Kentucky, Lexington
Ages 18 and older · Men · Updated Jul 14, 2026 · NCT05568550

Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors

RecruitingPhase 1
  • UK Markey Cancer Center, Lexington
Ages 18 and older · All sexes · Updated Jun 11, 2026 · NCT05283330

A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

RecruitingPhase 1
  • University of Kentucky Markey Cancer Center, Lexington
Ages 18 and older · All sexes · Updated Feb 13, 2026 · NCT06778863

Carboplatin Chemotherapy Before Surgery for People With High-Risk Prostate Cancer and an Inherited BRCA1 or BRCA2 Gene Mutation

RecruitingPhase 2
  • Saint Joseph Hospital, Lexington
  • Saint Joseph Radiation Oncology Resource Center, Lexington
  • Saint Joseph Hospital East, Lexington
Ages 18 and older · Men · Updated Jan 29, 2026 · NCT05806515

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

RecruitingObservational studyHealthy volunteers welcome
  • Baptist Lexington, Lexington
Ages 40 and older · All sexes · Updated Jan 20, 2026 · NCT05366881

Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

RecruitingPhase 3
  • Saint Joseph Radiation Oncology Resource Center, Lexington
  • Saint Joseph Hospital East, Lexington
  • University of Kentucky/Markey Cancer Center, Lexington
Ages 18 and older · Men · Updated Sep 11, 2025 · NCT03678025

About Prostate Cancer

Prostate cancer is one of the most common types of cancer among American men. The risk goes up as men age. Learn about symptoms, tests, and treatment.

More about Prostate Cancer on MedlinePlus

Prostate Cancer trials in other cities

Other studies in Lexington

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.