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Lymphedema clinical trials recruiting in the U.S.
25 studies for Lymphedema are recruiting participants at sites across the United States.
Lymphedema is the name of a type of swelling that happens when lymph builds up in your body's soft tissue. Discover causes and treatment options.
Cities with the most studies
- Houston, TX5 studies
- New York City, NY5 studies
- Philadelphia, PA3 studies
- Staten Island, NY3 studies
- New Rochelle, NY3 studies
- Queens, NY3 studies
By state
- California5 studies
- New Jersey4 studies
- New York5 studies
- Ohio3 studies
- Pennsylvania3 studies
- Texas6 studies
Recently updated studies
A Prospective Natural History Study of Lymphatic Anomalies
RecruitingObservational studyHealthy volunteers welcome
1 Day – 100 Years · All sexes · Updated Sep 28, 2026 · NCT05731141Lymphedema Prevention Through Immediate Lymphatic Reconstruction (LILY) Trial.
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06989099A Study Comparing Quality of Life in Patients With Lymphedema Who Undergo Surgical Treatment Versus Non-Surgical Management
RecruitingObservational study
Ages 18 to 80 · All sexes · Updated Sep 24, 2026 · NCT03248310Systemic Therapy of Open-label Prophylactic Pravastatin or Pentoxifylline/Tocopherol Prevention of Lymphedema Advancing to Eventual Fibrosis: an Interventional Registry-embedded Bayesian Randomized Trial for Radiation Sequelae (STOP4-LATE-FIBROSE)
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT06494111A Post-market, Real-world Experience: Expanding Access to Care by Incorporating the Symani® Surgical System and Enabling Surgeons
RecruitingObservational study
Ages 22 and older · All sexes · Updated Sep 11, 2026 · NCT06725030Self-Management for Head and Neck Lymphedema and Fibrosis [PROMISE Trial]
Recruiting
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT06125743LYMPHA Procedure for the Prevention of Lymphedema After Axillary Lymphadenectomy
Recruiting
Ages 18 to 75 · Women · Updated Aug 12, 2026 · NCT05366699Evaluate Advanced Pneumatic Compression Device With Revised Compression Programming for Lymphedema Treatment
RecruitingEarly phase 1
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT07613931IIT2023-09-Chung-UpfrontTAD: Upfront TAD/SNB in Patients With Breast Cancer With Nodal Metastases
RecruitingPhase 2
Ages 45 and older · Women · Updated Aug 10, 2026 · NCT06092892Axillary Radiotherapy or Axillary Lymph Node Dissection in Patients With Clinically Node- Positive Breast Cancer Undergoing Upfront Tailored Axillary Surgery
Recruiting
Ages 18 and older · All sexes · Updated Aug 7, 2026 · NCT07140172Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-controlled Orphan Drug Platform Trial for Orodental Sequelae (Reverse-fibrose)
RecruitingPhase 2
All ages · Women · Updated Jul 24, 2026 · NCT06912763Screening For BCRL In Targeted Therapy For Breast Cancer
RecruitingObservational study
Ages 18 to 80 · Women · Updated Jul 13, 2026 · NCT05142800Lymphedema Surveillance Study
RecruitingObservational study
Ages 18 and older · Women · Updated May 7, 2026 · NCT02743858Clinical Study to Evaluate the Effectiveness and Health Economics of a Novel Portable Non-Pneumatic Active Compression Device (NPCD) for Lymphedema/Phlebolymphedema
Recruiting
Ages 18 to 100 · All sexes · Updated May 4, 2026 · NCT06418282ILR to Prevent BRCL_MCC 23608
Recruiting
Ages 18 to 75 · Women · Updated Apr 30, 2026 · NCT07127003Prospective Screening for Breast Cancer-related Lymphedema
RecruitingObservational study
Ages 18 and older · Women · Updated Dec 24, 2025 · NCT01521741Vascular Lab Resource (VLR) Biorepository
RecruitingObservational study
Ages 18 and older · All sexes · Updated Dec 19, 2025 · NCT05628948A Study of a Comprehensive Prevention Program to Reduce Lymphedema After Axillary Lymph Node Dissection in People With Breast Cancer
RecruitingPhase 3
Ages 18 to 75 · Women · Updated Nov 10, 2025 · NCT06144164Post-mastectomy Recovery: Comparing Preoperative PECS-II Blocks With Intraoperative Pectoral Blocks
RecruitingPhase 4
Ages 18 and older · All sexes · Updated Nov 4, 2025 · NCT06574022A Real-World Registry of Chronic Wounds and Ulcers
RecruitingObservational study
All ages · All sexes · Updated Jul 16, 2025 · NCT02280733Efficacy of GLP-1 Receptor Agonists in Treating Upper and Lower Extremity Lymphedema
RecruitingEarly phase 1
Ages 18 and older · All sexes · Updated Jun 10, 2025 · NCT07012642LymphBridge: Surgical Evaluation for Breast Cancer-Associated Lymphedema (BioBridge)
Recruiting
Ages 18 to 75 · All sexes · Updated Mar 11, 2025 · NCT04606030Surgical Evaluation for Upper Extremity Lymphedema (BioBridge)
Recruiting
Ages 18 to 75 · All sexes · Updated Mar 11, 2025 · NCT05695924Pedal Pump and Leg Lymphedema
RecruitingHealthy volunteers welcome
Ages 55 to 100 · All sexes · Updated Nov 18, 2024 · NCT06235463A Non-randomized, Open-Label Study to Evaluate the Safety and Effectiveness of the Dayspring Technology for Patients With Breast Cancer Related Lymphedema (BCRL) After Lymphatic Surgery
Recruiting
Ages 18 and older · All sexes · Updated May 20, 2021 · NCT04888975From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.