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Lymphedema clinical trials recruiting in the U.S.

25 studies for Lymphedema are recruiting participants at sites across the United States.

Lymphedema is the name of a type of swelling that happens when lymph builds up in your body's soft tissue. Discover causes and treatment options.

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Recently updated studies

A Prospective Natural History Study of Lymphatic Anomalies

RecruitingObservational studyHealthy volunteers welcome
1 Day – 100 Years · All sexes · Updated Sep 28, 2026 · NCT05731141

Lymphedema Prevention Through Immediate Lymphatic Reconstruction (LILY) Trial.

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06989099

A Study Comparing Quality of Life in Patients With Lymphedema Who Undergo Surgical Treatment Versus Non-Surgical Management

RecruitingObservational study
Ages 18 to 80 · All sexes · Updated Sep 24, 2026 · NCT03248310

A Post-market, Real-world Experience: Expanding Access to Care by Incorporating the Symani® Surgical System and Enabling Surgeons

RecruitingObservational study
Ages 22 and older · All sexes · Updated Sep 11, 2026 · NCT06725030

Self-Management for Head and Neck Lymphedema and Fibrosis [PROMISE Trial]

Recruiting
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT06125743

LYMPHA Procedure for the Prevention of Lymphedema After Axillary Lymphadenectomy

Recruiting
Ages 18 to 75 · Women · Updated Aug 12, 2026 · NCT05366699

Evaluate Advanced Pneumatic Compression Device With Revised Compression Programming for Lymphedema Treatment

RecruitingEarly phase 1
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT07613931

IIT2023-09-Chung-UpfrontTAD: Upfront TAD/SNB in Patients With Breast Cancer With Nodal Metastases

RecruitingPhase 2
Ages 45 and older · Women · Updated Aug 10, 2026 · NCT06092892

Screening For BCRL In Targeted Therapy For Breast Cancer

RecruitingObservational study
Ages 18 to 80 · Women · Updated Jul 13, 2026 · NCT05142800

Lymphedema Surveillance Study

RecruitingObservational study
Ages 18 and older · Women · Updated May 7, 2026 · NCT02743858

ILR to Prevent BRCL_MCC 23608

Recruiting
Ages 18 to 75 · Women · Updated Apr 30, 2026 · NCT07127003

Prospective Screening for Breast Cancer-related Lymphedema

RecruitingObservational study
Ages 18 and older · Women · Updated Dec 24, 2025 · NCT01521741

Vascular Lab Resource (VLR) Biorepository

RecruitingObservational study
Ages 18 and older · All sexes · Updated Dec 19, 2025 · NCT05628948

Post-mastectomy Recovery: Comparing Preoperative PECS-II Blocks With Intraoperative Pectoral Blocks

RecruitingPhase 4
Ages 18 and older · All sexes · Updated Nov 4, 2025 · NCT06574022

A Real-World Registry of Chronic Wounds and Ulcers

RecruitingObservational study
All ages · All sexes · Updated Jul 16, 2025 · NCT02280733

Efficacy of GLP-1 Receptor Agonists in Treating Upper and Lower Extremity Lymphedema

RecruitingEarly phase 1
Ages 18 and older · All sexes · Updated Jun 10, 2025 · NCT07012642

LymphBridge: Surgical Evaluation for Breast Cancer-Associated Lymphedema (BioBridge)

Recruiting
Ages 18 to 75 · All sexes · Updated Mar 11, 2025 · NCT04606030

Surgical Evaluation for Upper Extremity Lymphedema (BioBridge)

Recruiting
Ages 18 to 75 · All sexes · Updated Mar 11, 2025 · NCT05695924

Pedal Pump and Leg Lymphedema

RecruitingHealthy volunteers welcome
Ages 55 to 100 · All sexes · Updated Nov 18, 2024 · NCT06235463

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.